A5057790013- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Systemic Lupus Erythematosus Research
- Musculoskeletal pain and rehabilitation
- Musculoskeletal Disorders and Rehabilitation
- Immunodeficiency and Autoimmune Disorders
- Adolescent and Pediatric Healthcare
- Lymphoma Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
- Dermatology and Skin Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Chronic Lymphocytic Leukemia Research
- Bone and Joint Diseases
- Urticaria and Related Conditions
- Cytokine Signaling Pathways and Interactions
- Childhood Cancer Survivors' Quality of Life
- Inflammasome and immune disorders
- Gout, Hyperuricemia, Uric Acid
- Osteoarthritis Treatment and Mechanisms
- Immune Cell Function and Interaction
- Chronic Disease Management Strategies
- Inflammatory Myopathies and Dermatomyositis
Keele University
2012-2024
University of Nottingham
2014-2024
Midlands Partnership NHS Foundation Trust
2020-2024
Haywood Community Hospital
2014-2024
Versus Arthritis
2010-2024
University of Manchester
2010-2024
NIHR Manchester Biomedical Research Centre
2015-2024
Lifespan
2022-2024
Manchester University NHS Foundation Trust
2023
Manchester Academic Health Science Centre
2023
Nature Communications 6: Article number: 6046 (2015); Published 5 February 2015; Updated 6 July 2015 The affiliation details for Emiliano Giardina are incorrect in this Article. correct address author is given below: Department of Biopathology, Centre Excellence Genomic Risk Assessment Multifactorial and Complex Diseases, School Medicine, University Rome 'Tor Vergata' Laboratory Molecular Genetics UILDM, Fondazione Santa Lucia, 00179, Italy.
Objective. To examine the clinical and functional outcome of adults with juvenile idiopathic arthritis (JIA) using recent World Health Organization/International League Against Rheumatism (ILAR) classification. Patients methods. Two hundred fifty‐nine long‐standing JIA (average disease duration 28.3 yr) were eligible for study; 246 (95%) attended an interview, examination notes review 231 (89.2%) returned a comprehensive psychosocial self‐assessment questionnaire. Results. Of all patients,...
Objective. MTX is widely used to treat synovitis in PsA without supporting trial evidence. The aim of our study was test the value first large randomized placebo-controlled (RCT) PsA. Methods. A 6-month double-blind RCT compared (15 mg/week) with placebo active primary outcome response criteria (PsARC). Other outcomes included ACR20, DAS-28 and their individual components. Missing data were imputed using multiple imputation methods. Treatments logistic regression analysis (adjusted for age,...
Abstract Psoriatic arthritis (PsA) is a chronic inflammatory associated with psoriasis and, despite the larger estimated heritability for PsA, majority of genetic susceptibility loci identified to date are shared psoriasis. Here, we present results from case–control association study on 1,962 PsA patients and 8,923 controls using Immunochip genotyping array. We identify eight passing genome-wide significance, secondary independent effects at three distinct PsA-specific variant IL23R locus....
<h3>Objectives</h3> To investigate a shared genetic aetiology for skin involvement in psoriasis and psoriatic arthritis (PsA) by genotyping single-nucleotide polymorphisms (SNPs), reported to be associated genome-wide association studies of psoriasis, patients with PsA. <h3>Methods</h3> SNPs evidence were genotyped PsA case control collection from the UK Ireland. Genotype allele frequencies compared between cases controls using Armitage test trend. <h3>Results</h3> Seven mapping IL1RN,...
To characterize the 10 year relationship between anti-transcriptional intermediary factor 1 antibody (anti-TIF1-Ab) positivity and cancer onset in a large UK-based adult DM cohort.Data from anti-TIF1-Ab-positive/-negative adults with verified diagnoses of UK Myositis Network register were analysed. Each patient was followed up until they developed cancer. Kaplan-Meier methods Cox proportional hazard modelling employed to estimate cumulative incidence.Data 263 cases analysed, total 3252...
To examine social function, relationships and sexual activity in adults with juvenile idiopathic arthritis (JIA).Two hundred forty-six identified long-standing JIA had an average disease duration of 28.3 yr. Specific information was sought on marital status, offspring, age at first encounter, problems related to pregnancy.Fewer patients (42.8%) were stable than their siblings (55.3%). The percentage children 27.5. Twenty-three per cent all known pregnancies ended miscarriage. Of the women...
Objective. To examine the predictive factors for anxiety, depression and pain in adults with juvenile idiopathic arthritis (JIA).
Objective. To examine the levels of education and employment in adults with juvenile idiopathic arthritis (JIA) compared their siblings national figures. Patients methods. Two hundred forty‐six identified long‐standing JIA had an average disease duration 28.3 yr. Educational achievements status were recorded comparative data obtained from National Office for Statistics, UK. The effects, incidence nature discrimination workplace also explored. Results. Across all study group achieved...
Depression is common in RA and may be influenced by both disease activity severity. The aims of this study were to investigate the prevalence depression patients starting anti-TNF therapy, how mood alters after exposure determine whether recognized appropriately managed clinic.Patients therapy assessed for using Hospital Anxiety Scale (HADS-D), classified as depressed with an HADS-D > or =8. Change was at 6 weeks, 4 months 12 months. Disease data recorded baseline, 3 Patients who remained...
Changes to the DNA methylome have been described in patients with rheumatoid arthritis (RA). In previous work, we reported genome-wide methylation differences T-lymphocyte and B-lymphocyte populations from healthy individuals. Now, using HumanMethylation450 BeadChips interrogate methylation, determined disease-associated changes blood-derived T- 12 female seropositive established RA, relative matched Array data were analyzed NIMBL software bisulfite pyrosequencing was used validate array...
ObjectivesThe aim of this study was to determine the extent which structural damage, clinical disease activity, demographic and social factors are associated with work disability (WD) in psoriatic arthritis (PsA). MethodsFour hundred patients fulfilling CASPAR criteria for PsA were recruited from 23 hospitals across UK.Demographic, socioeconomic, work, radiographic data collected.WD assessed WPAI-SHP reporting as percentage absenteeism (work time missed), presenteeism (impairment at...
To estimate the proportion of patients with axial spondyloarthritis (SpA) in a UK national biologics registry who met criteria for fibromyalgia (FM), and to delineate characteristics these patients.Two cohorts are prospectively recruited from across 83 centers British Society Rheumatology Biologics Register Ankylosing Spondylitis (BSRBR-AS). All required meet Assessment SpondyloArthritis international (ASAS) SpA. Patients either newly starting biologic therapy (biologics cohort) or naive...
Psoriatic arthritis (PsA) has a strong genetic component, and the identification of risk factors could help identify ~30% psoriasis patients at high developing PsA. Our objectives were to pathways that differentiate PsA from cutaneous-only (PsC) evaluate performance prediction models.Genome-wide meta-analyses conducted separately for 5,065 with 21,286 healthy controls 4,340 6,431 PsC. The heritability was calculated as single-nucleotide polymorphism (SNP)-based estimate (h2SNP ) biologic PsC...
Abstract Introduction Diagnosis of axial spondyloarthritis (axSpA) is frequently delayed for years after symptom onset. However, little known about patient and healthcare professional (HCP) perspectives on barriers facilitators in axSpA diagnosis. This study explored the experiences perceptions both groups regarding factors affecting timely diagnosis axSpA. Method Semi-structured interviews with patients axSpA-interested HCPs from United Kingdom (UK) were performed by telephone or Microsoft...
Objective There is great interest in the identification of genetic factors that differentiate psoriatic arthritis (PsA) from psoriasis vulgaris (PsV), as such discoveries could lead to distinct underlying aetiological pathways. Recent studies identified single nucleotide polymorphisms (SNPs) interleukin 13 ( IL-13 ) gene region risk for PsV. Further investigations one these found effect be primarily restricted PsA, thus suggesting discovery a specific factor PsA. Given this intriguing...
Objectives: To examine the impact of ankylosing spondylitis (AS) on patients across UK and to identify factors associated with unemployment, absenteeism, presenteeism.Methods: One thousand AS from 10 specialist rheumatology centres were invited participate in a study evaluating new outcome measure. Patients completed questionnaire, which included questions relating their work, sociodemographic clinical characteristics.Results: The questionnaire was by 612 (438 males; 72%). mean age...
Objective. To investigate the relationship between smoking and disease activity, pain, function, quality of life in patients with ankylosing spondylitis (AS). Methods. Patients AS (n = 612) from areas across United Kingdom took part a cross-sectional postal survey. Patient-reported outcome measures including Bath Disease Activity Index, Functional Index (BASFI), numerical rating scale (NRS) questionnaire (ASQoL), evaluation (EASi-QoL) were analyzed terms status pack-year history. The...
Juvenile idiopathic arthritis (JIA) is an umbrella term for all chronic childhood arthropathies and can be divided into seven subtypes. It includes the enthesitis related (ERA) subtype which displays symptoms similar to ankylosing spondylitis (AS) juvenile-onset psoriatic has similarities (PsA) psoriasis (Ps). We, therefore, hypothesized that two well-established susceptibility loci AS Ps, ERAP1 IL23R, could also confer these JIA Single nucleotide polymorphisms (SNPs) in (rs30187) IL23R...
Abstract Introduction The pathology of ankylosing spondylitis (AS) suggests that certain cytokines and matrix metalloproteinases (MMPs) might provide useful markers disease activity. Serum levels some MMPs have been found to be elevated in active disease, but there is a general lack information about biomarker profiles AS how these are related activity function. purpose this study was investigate whether clinical measures function associated with particular circulating MMPs. Methods...
<h3>Objectives</h3> Psoriatic arthritis (PsA) is a chronic inflammatory arthritis, with strong heritable component, affecting patients psoriasis. Here we attempt to identify genetic variants within the major histocompatibility complex (MHC) that differentiate PsA from cutaneous psoriasis alone (PsC). <h3>Methods</h3> 2808 PsC, 1945 and 8920 population controls were genotyped. We imputed SNPs, amino acids classical HLA alleles across MHC tested for association compared PsC patient group. In...