A5038632710- Rheumatoid Arthritis Research and Therapies
- Bone Metabolism and Diseases
- Bone health and osteoporosis research
- Spondyloarthritis Studies and Treatments
- Connective tissue disorders research
- Bone and Joint Diseases
- Bone health and treatments
- Orthopedic Surgery and Rehabilitation
- Systemic Lupus Erythematosus Research
- S100 Proteins and Annexins
- Musculoskeletal synovial abnormalities and treatments
- Immunotherapy and Immune Responses
- Hip disorders and treatments
- Bone fractures and treatments
- Cytokine Signaling Pathways and Interactions
- SARS-CoV-2 and COVID-19 Research
- Macrophage Migration Inhibitory Factor
- Biomarkers in Disease Mechanisms
- Diet and metabolism studies
- Dietary Effects on Health
- Thyroid Disorders and Treatments
- Circadian rhythm and melatonin
- Adrenal Hormones and Disorders
- Hip and Femur Fractures
- Fibromyalgia and Chronic Fatigue Syndrome Research
University Hospital of Bern
2015-2025
Medical University of Vienna
2023-2025
Regionalspital Emmental
2023-2025
University of Bern
2010-2023
University of Geneva
2010
University Hospital of Geneva
2010
University Hospital of Basel
2010
SCQM Foundation
2010
Monash University
2006-2009
Monash Health
2009
B-cell-depleting therapies increase the risk of morbidity and mortality due to COVID-19. Evidence-based SARS-CoV-2 vaccination strategies for patients on are scarce. We aimed investigate humoral cell-mediated immune responses mRNA-based vaccines in receiving CD20-targeted agents autoimmune disease, malignancy, or transplantation.The RituxiVac study was an investigator-initiated, single-centre, open-label done at Bern University Hospital (Bern, Switzerland). Patients with a treatment history...
Weight loss is key to controlling the increasing prevalence of metabolic syndrome (MS) and its components, i.e., central obesity, hypertension, prediabetes dyslipidaemia. The goals our study were two-fold. First, we characterised relationships between eating duration, unprocessed processed food consumption health. During 4 weeks observation, 213 adults used a smartphone application record drink consumption, which was annotated for processing levels following NOVA classification. Low low...
Annexin-1 (ANXA1) is a mediator of the anti-inflammatory actions endogenous and exogenous glucocorticoids (GC). The mechanism ANXA1 effects on cytokine production in macrophages unknown here investigated vivo vitro. In response to LPS administration, ANXA1(-/-) mice exhibited significantly increased serum IL-6 TNF compared with wild-type (WT) controls. Similarly, LPS-induced were greater than WT peritoneal addition, deficiency was associated impairment inhibitory dexamethasone (DEX)...
To examine the potential of two tumour necrosis factor (TNF) inhibitors infliximab and etanercept as remission-inducing agents in chronic therapy-resistant inflammatory disorders immune or non-immune pathogenesis.14 patients with adult Still's disease/macrophage activation syndrome (4), Wegener's disease (3), Behçet's keratoscleritis (1), lymphomatous tracheo-bronchitis (1) Cogan's rapidly destructive crystal arthropathy were treated (n = 10) 4). All showed organ-threatening progression...
The pro‐inflammatory cytokine macrophage migration inhibitory factor (MIF) is induced by glucocorticoids (GCs), but it was not previously known if MIF regulates cellular sensitivity to GC. Here we show in GC and LPS‐treated peritoneal macrophages derived from MIF−/− wt mice that the absence of endogenous associated with increased TNF release. This expression mitogen‐activated protein kinase (MAPK) phosphatase‐1 (MKP‐1), concomitant decreased phosphorylation p38 MAPK, no effect on nuclear κB...
Objective. To explore the regulation of factors involved in lymphocyte trafficking patients with rheumatoid arthritis (RA) undergoing treatment tumour necrosis factor α (TNF-α) inhibitors.
Abstract Macrophage migration inhibitory factor (MIF) has a key role in regulation of innate and adaptive immunity is implicated sepsis, tumorigenesis, autoimmune disease. MIF deficiency or immunoneutralization leads to protection against fatal endotoxic, exotoxic, infective shock, anti-inflammatory effects other experimental models inflammatory We report novel regulatory type 1 IL-1R p55 TNFR expression function. Compared with wild-type cells, MIF-deficient cells were hyporesponsive IL-1-...
Abstract Background loss of skeletal muscle function, strength and mass is common in older adults, with important socioeconomic impacts. Subclinical hypothyroidism increasing age has been associated reduced strength. Yet, no randomized placebo-controlled trial (RCT) investigated whether treatment subclinical affects function mass. Methods this an ancillary study within two RCTs conducted among adults aged ≥65 years persistent (thyrotropin (TSH) 4.60–19.99 mIU/l, normal free thyroxine)....
Abstract Introduction Reconstitution of peripheral blood (PB) B cells after therapeutic depletion with the chimeric anti-CD20 antibody rituximab (RTX) mimics lymphatic ontogeny. In this situation, repletion kinetics and migratory properties distinct developmental B-cell stages their correlation to disease activity might facilitate our understanding innate adaptive functions in rheumatoid arthritis (RA). Methods Thirty-five 'RTX-naïve' RA patients active were treated failure tumour necrosis...
Background The majority of patients with B-cell-depleting therapies show compromised vaccination-induced immune responses. Herein, we report on the trajectories anti-SARS-CoV-2 responses in RituxiVac study compared healthy volunteers and investigate immunogenicity a third vaccination previously humoral non-responding patients. Methods We investigated cell-mediated response after SARS-CoV-2 messanger RNA history anti-CD20 therapies. Coprimary outcomes were antispike SARS-CoV-2-stimulated...
Abstract Context Both thyroid dysfunction and levothyroxine (LT4) therapy have been associated with bone loss, but studies on the effect of LT4 for subclinical hypothyroidism (SHypo) yielded conflicting results. Objective To assess treatment mineral density (BMD), Trabecular Bone Score (TBS), turnover markers (BTMs) in older adults SHypo. Design Intervention Planned nested substudy double-blind placebo-controlled TRUST trial. Participants SHypo were randomized to dose titration versus...
Abstract Annexin 1 (Anx-1) is a mediator of the anti-inflammatory actions glucocorticoids, but mechanism its effects not known. We investigated role Anx-1 in regulation proinflammatory cytokine, IL-6. Lung fibroblast cell lines derived from Anx-1−/− and wild-type (WT) mice were treated with dexamethasone and/or IL-1. IL-6 mRNA protein measured using real-time PCR ELISA, MAPK pathway activation was studied. Compared WT cells, unstimulated cells exhibited dramatically increased basal...
Abstract Aseptic pachymeningitis is a rare and serious complication of rheumatoid arthritis (RA). Herein, we describe patient with factor–positive anti–cyclic citrullinated peptide–positive RA who experienced focal seizure, aphasia convulsions the right side body. The findings magnetic resonance imaging histologic analysis led to diagnosis pachymeningitis. Because had large number CD20‐expressing B lymphocytes, therapy rituximab was started has resulted in complete sustained remission both...
The objective of this study was to assess three-dimensional bone geometry and density at the epiphysis shaft third meta-carpal rheumatoid arthritis (RA) patients in comparison healthy controls with novel method peripheral quantitative computed tomography (pQCT).PQCT scans were performed 50 female RA 100 distal epiphyses shafts metacarpal bone, radius tibia. Reproducibility determined by coefficient variation. Bone densitometric geometric parameters compared between two groups correlated...
To investigate the effects of interleukin-17A (IL-17A) on osteoclastogenesis in vitro.Bone marrow cells (BMCs) were isolated from excised tibia and femora wild-type C57BL/6J mice, osteoblasts obtained by sequential digestion calvariae ddY, C57BL/6J, granulocyte-macrophage colony-stimulating factor-knockout (GM-CSF(-/-)) mice. Monocultures BMCs or cocultures supplemented with without 1,25-dihydroxyvitamin D(3)(1,25[OH](2)D(3)), recombinant human macrophage factor (M-CSF), RANKL, IL-17A. After...
Abstract Weight loss is key to control the increasing prevalence of metabolic syndrome (MS) and its components, i.e. central obesity, hypertension, prediabetes, dyslipidaemia. We characterised relationships between eating duration, unprocessed processed food consumption, health. During 4 weeks observation, 213 adults used a smartphone application record drink which was annotated for processing levels following NOVA classification. Consumption items showed highest number significant...
The effect of levothyroxine (LT4) therapy for subclinical hypothyroidism (SHypo) on appendicular bone geometry and volumetric density has so far not been studied. In a nested study within the randomized, placebo-controlled Thyroid Hormone Replacement Subclinical Hypothyroidism (TRUST) trial, we assessed LT4 as measured by peripheral quantitative computed tomography (pQCT). TRUST community-dwelling adults aged ≥65 years with SHypo were randomized to dose titration vs. placebo mock titration....
Disorders of isolated mineralocorticoid deficiency, which cause potentially life-threatening salt-wasting crisis early in life, have been associated with gene variants aldosterone biosynthesis or resistance; however, some patients no such are found. WNT/β-catenin signaling is crucial for differentiation and maintenance the aldosterone-producing adrenal zona glomerulosa (zG). Herein, we describe a highly consanguineous family multiple perinatal deaths infants presenting at birth failure to...
Objectives. Recent studies have suggested that areal BMD (aBMD) measured by DXA is elevated in patients with DISH. We used peripheral QCT (pQCT) to assess volumetric (vBMD) and bone geometry of the radius, tibia third metacarpal bone.