A5004291450- Adrenal and Paraganglionic Tumors
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Hormonal Regulation and Hypertension
- Glioma Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- interferon and immune responses
- ATP Synthase and ATPases Research
- Protease and Inhibitor Mechanisms
- Pharmacology and Obesity Treatment
- Immune cells in cancer
- Diabetes and associated disorders
- Adrenal Hormones and Disorders
- Metabolism and Genetic Disorders
- Pharmaceutical studies and practices
- Neurological Complications and Syndromes
- Growth Hormone and Insulin-like Growth Factors
- Pharmacogenetics and Drug Metabolism
- Neuroscience of respiration and sleep
- Neurological and metabolic disorders
- Endoplasmic Reticulum Stress and Disease
- Genetics and Neurodevelopmental Disorders
- Ion Transport and Channel Regulation
- Neuroblastoma Research and Treatments
- Neonatal Respiratory Health Research
Centre Hospitalier Universitaire de Clermont-Ferrand
2021-2025
Genetique Reproduction and Developpement
2019-2024
Inserm
2021-2022
Université Clermont Auvergne
2022
Centre National de la Recherche Scientifique
2021-2022
Clermont Université
2022
Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with poor prognosis in advanced stages. While therapies targeting the checkpoint molecules programmed cell death 1 (PD-1), its ligand PD-L1, and cytotoxic T lymphocyte-associated protein 4 (CTLA-4) have revolutionized treatment many cancers, results ACCs were heterogeneous.
ABSTRACT Background and Hypothesis Post‐transplant diabetes mellitus (PTDM) is a common, dynamic complication after kidney transplantation (KT) that may resolve over time. To better understand prevent PTDM, we analyzed its prevalence, evolution, influencing factors. Methods Data from the French national ASTRE database at different post‐transplantation periods (P) were analyzed. PTDM was defined by fasting blood glucose (FBG) ≥1.26 g/L, HbA1c ≥ 6.5%, or use of hypoglycemic medications in...
Unlike most cancers, adrenocortical carcinomas (ACCs) are more frequent in women than men, but the underlying mechanisms of this sexual dimorphism remain elusive. Here, we show that inactivation
Disorders of isolated mineralocorticoid deficiency, which cause potentially life-threatening salt-wasting crisis early in life, have been associated with gene variants aldosterone biosynthesis or resistance; however, some patients no such are found. WNT/β-catenin signaling is crucial for differentiation and maintenance the aldosterone-producing adrenal zona glomerulosa (zG). Herein, we describe a highly consanguineous family multiple perinatal deaths infants presenting at birth failure to...
SUMOylation is a dynamic posttranslational modification, that provides fine-tuning of protein function involved in the cellular response to stress, differentiation, and tissue development. In adrenal cortex, an emblematic endocrine organ mediates adaptation physiological demands, gradient inversely correlated with differentiation raising important questions about its role functional zonation stress. Considering SUMO-specific protease 2 (SENP2), deSUMOylating enzyme, upregulated by...
Summary In contrast with most cancers, adrenocortical carcinomas (ACC) are more frequent in women than men, but the underlying mechanisms of this sexual dimorphism remain elusive. Homozygous deletion negative WNT pathway regulator ZNRF3 is alteration ACC patients. Here, we show that Cre-mediated inactivation Znrf3 steroidogenic cells mouse adrenal cortex associated sexually dimorphic tumour progression. Indeed, although knockout female mice develop metastatic over an 18 month-time course,...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
The murine adrenal cortex is a constantly self-renewed endocrine organ composed of concentric zones, including the outermost zona glomerulosa (zG) producing mineralocorticoids and innermost fasciculata (zF) glucocorticoids. According to centripetal migration model occurring during postnatal development, progenitor cell populations located in capsule or within zG, consecutively differentiate into steroid-producing zG cells, then through process zonal transdifferentiation, convert zF...
Abstract SUMOylation is a dynamic posttranslational modification, that provides fine-tuning of protein function involved in the cellular response to stress, differentiation, and tissue development. In adrenal cortex, an emblematic endocrine organ mediates adaptation physiological demands, gradient inversely correlated with differentiation raising important questions about its role functional zonation stress. Considering SUMO-specific protease 2 (SENP2), deSUMOylating enzyme, upregulated by...
Abstract SUMOylation is a dynamic posttranslational modification, that provides fine-tuning of protein function involved in the cellular response to stress, differentiation, and tissue development. In adrenal cortex, an emblematic endocrine organ mediates adaptation physiological demands, gradient inversely correlated with differentiation raising important questions about its role functional zonation stress. Considering SUMO-specific protease 2 (SENP2), deSUMOylating enzyme, upregulated by...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)