A5090161874- Atherosclerosis and Cardiovascular Diseases
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- CAR-T cell therapy research
- Aortic aneurysm repair treatments
- Congenital heart defects research
- Nuclear Receptors and Signaling
- Aortic Disease and Treatment Approaches
- RNA modifications and cancer
- Single-cell and spatial transcriptomics
- Connective tissue disorders research
- Cancer-related molecular mechanisms research
- Cardiovascular Disease and Adiposity
- RNA regulation and disease
- Neuropeptides and Animal Physiology
- Chronic Myeloid Leukemia Treatments
- Cancer Immunotherapy and Biomarkers
- Developmental Biology and Gene Regulation
- Cardiovascular Function and Risk Factors
- Cancer Research and Treatments
- Cancer-related gene regulation
- Chemotherapy-induced cardiotoxicity and mitigation
- Long-Term Effects of COVID-19
- Mast cells and histamine
- Immune cells in cancer
Stanford University
2008-2025
Cardiovascular Institute of the South
2019-2025
Stanford Medicine
2008-2023
Kite (United States)
2018-2023
Moffitt Cancer Center
2021
Dana-Farber Cancer Institute
2021
Memorial Sloan Kettering Cancer Center
2021
Stanford Blood Center
2020
University of California, San Francisco
1990-2016
Atlanta Allergy and Asthma Clinic
2016
The prognosis of patients with early relapsed or refractory large B-cell lymphoma after the receipt first-line chemoimmunotherapy is poor.In this international, phase 3 trial, we randomly assigned, in a 1:1 ratio, that was to had no more than 12 months receive axicabtagene ciloleucel (axi-cel, an autologous anti-CD19 chimeric antigen receptor T-cell therapy) standard care (two three cycles investigator-selected, protocol-defined chemoimmunotherapy, followed by high-dose chemotherapy...
In an analysis of the primary outcome this phase 3 trial, patients with early relapsed or refractory large B-cell lymphoma who received axicabtagene ciloleucel (axi-cel), autologous anti-CD19 chimeric antigen receptor T-cell therapy, as second-line treatment had significantly longer event-free survival than those standard care. Data were needed on longer-term outcomes. Download a PDF Research Summary. we randomly assigned in 1:1 ratio to receive either axi-cel care (two three cycles...
Objective: To delineate temporal and spatial dynamics of vascular smooth muscle cell (SMC) transcriptomic changes during aortic aneurysm development in Marfan syndrome (MFS). Approach Results: We performed single-cell RNA sequencing to study root/ascending tissue from Fbn1 C1041G/ + (MFS) mice healthy controls, identifying all types. A distinct cluster transcriptomically modulated SMCs (modSMCs) was identified adult mouse only. Comparison with atherosclerotic data (ApoE −/− mice) revealed...
<h3>Importance</h3> Early detection and characterization of increased left ventricular (LV) wall thickness can markedly impact patient care but is limited by under-recognition hypertrophy, measurement error variability, difficulty differentiating causes thickness, such as cardiomyopathy, cardiac amyloidosis. <h3>Objective</h3> To assess the accuracy a deep learning workflow in quantifying hypertrophy predicting cause LV thickness. <h3>Design, Settings, Participants</h3> This cohort study...
Abstract The phase 3 ZUMA-7 trial in second-line large B cell lymphoma demonstrated superiority of anti-CD19 CAR T therapy (axicabtagene ciloleucel (axi-cel)) over standard care (SOC; salvage chemotherapy followed by hematopoietic transplantation) ( NCT03391466 ). Here, we present a prespecified exploratory analysis examining the association between pretreatment tumor characteristics and efficacy axi-cel versus SOC. gene expression signature (GES) CD19 associated significantly with improved...
Abstract The activation of innate immune cells triggers numerous intracellular signaling pathways, which require tight control to mount an adequate response. PI3K pathway is intricately involved in immunity, and its dampens the expression release proinflammatory cytokines myeloid cells. These processes are strictly regulated by antagonist, lipid phosphatase, PTEN, a known tumor suppressor. Importantly, PTEN responsible for elevated production such as IL-6 response TLR agonists, deletion...
Rationale: The gene encoding TCF21 (transcription factor 21) has been linked to coronary artery disease risk by human genome-wide association studies in multiple racial ethnic groups. In murine models, Tcf21 is required for phenotypic modulation of smooth muscle cells (SMCs) atherosclerotic tissues and promotes a fibroblast phenotype these cells. humans, expression inhibits disease. molecular mechanism which regulates SMC not known. Objective: To better understand how affects the phenotype,...
Smooth muscle cells (SMC) play a critical role in atherosclerosis. The Aryl hydrocarbon receptor (AHR) is an environment-sensing transcription factor that contributes to vascular development, and has been implicated coronary artery disease risk. We hypothesized AHR can affect atherosclerosis by regulating phenotypic modulation of SMC.We combined RNA-sequencing, chromatin immunoprecipitation followed sequencing, assay for transposase-accessible using vitro assays human SMCs, with single-cell...
Coronary artery disease is an incurable, life-threatening that was once considered primarily a disorder of lipid deposition. now also characterized by chronic inflammation' notable for the buildup atherosclerotic plaques containing immune cells in various states activation and differentiation. Understanding how these contribute to progression may lead development novel therapeutic strategies.
Smooth muscle cells (SMCs) transition into a number of different phenotypes during atherosclerosis, including those that resemble fibroblasts and chondrocytes, make up the majority in atherosclerotic plaque. To better understand epigenetic transcriptional mechanisms mediate these cell state changes, how they relate to risk for coronary artery disease (CAD), we have investigated causality function transcription factors at genome-wide associated loci.
Here, we report the first comparative analysis of patient-reported outcomes (PROs) with chimeric antigen receptor T-cell therapy vs standard-of-care (SOC) in second-line relapsed/refractory large B-cell lymphoma (R/R LBCL) from pivotal randomized phase 3 ZUMA-7 study axicabtagene ciloleucel (axi-cel) SOC. PRO instruments were administered at baseline, day 50, 100, 150, month 9, and every months randomization until 24 or an event-free survival event. The quality life (QoL) set comprised...
Rationale: Formation and remodeling of the vasculature during development disease involve a highly conserved precisely regulated network attractants repellants. Various signaling pathways control behavior endothelial cells, but their posttranscriptional dose titration by microRNAs is poorly understood. Objective: To identify that regulate angiogenesis. Methods Results: We show microRNA family encoding miR-10 regulates cells angiogenesis positively titrating proangiogenic signaling. Knockdown...
Abstract Multinucleated giant cells (MGCs) are implicated in many diseases including schistosomiasis, sarcoidosis and arthritis. MGC generation is energy intensive to enforce membrane fusion cytoplasmic expansion. Using receptor activator of nuclear factor kappa-Β ligand (RANKL) induced osteoclastogenesis model formation, here we report RANKL cellular programming requires extracellular arginine. Systemic arginine restriction improves outcome multiple murine arthritis models its removal...
Genome wide association studies for coronary artery disease (CAD) have identified a risk locus at 11q22.3. Here, we verify with mechanistic that rs2019090 and PDGFD represent the functional variant gene this locus. Further, FOXC1/C2 transcription factor binding is shown to promote through CAD promoting allele. With single cell transcriptomic histology Pdgfd knockdown in an SMC lineage tracing male atherosclerosis mouse model find promotes expansion, migration, transition of cells...
Non-cell-autonomous signals often play crucial roles in cell fate decisions during animal development. Reciprocal signaling between endoderm and mesoderm is vital for embryonic development, yet the key mechanisms remain unclear. Here, we show that endodermal cells efficiently promote emergence of mesodermal neighboring population through containing an essential short-range component. The endoderm-mesoderm interaction promoted precardiac formation mouse stem involved production fibronectin....
Arginine is a semi‐essential amino acid that plays key role in cell survival and proliferation normal malignant cells. BCT‐100, pegylated (PEG) recombinant human arginase, can deplete arginine starve cells of the acid. Acute lymphoblastic leukemia (ALL) most common cancer childhood, yet for patients with high risk or relapsed disease prognosis remains poor. We show BCT‐100 cytotoxic to ALL blasts from vitro by necrosis, synergistic combination dexamethasone. Against xenografts, leads...