A5055655637- Child Nutrition and Water Access
- Atherosclerosis and Cardiovascular Diseases
- Apelin-related biomedical research
- Poverty, Education, and Child Welfare
- Congenital heart defects research
- Birth, Development, and Health
- Single-cell and spatial transcriptomics
- Craniofacial Disorders and Treatments
- Global Maternal and Child Health
- Dietary Effects on Health
- RNA modifications and cancer
- Obesity, Physical Activity, Diet
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Lipid metabolism and disorders
- Phagocytosis and Immune Regulation
- Developmental Biology and Gene Regulation
- Cancer-related molecular mechanisms research
- Nuclear Receptors and Signaling
- Cleft Lip and Palate Research
- dental development and anomalies
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Advanced Breast Cancer Therapies
- Protein Tyrosine Phosphatases
- Hair Growth and Disorders
West Bengal State University
2017-2025
Centre for Mental Health
2024
Stanford University
2007-2024
Stanford Medicine
2023
Indian Council of Medical Research
2023
Cardiovascular Institute of the South
2020-2022
Purple Mountain Observatory
2007
Agilent Technologies (United States)
2005
Cardiovascular Research Center
2005
USC Norris Comprehensive Cancer Center
1995-1996
The endogenous peptide apelin is differentially regulated in cardiovascular disease but the nature of its role cardiac function remains unclear.We investigated functional relevance this using ECG and respiration gated magnetic resonance imaging, conductance catheter pressure-volume hemodynamic measurements, echocardiography vivo. In addition, we carried out histology immunohistochemistry to assess hypertrophy localize APJ adult embryonic mouse heart.Intraperitoneal injection (300 microg/kg)...
The coordinate growth of the brain and skull is achieved through a series interactions between developing brain, growing bones skull, fibrous joints, or sutures, that unite bones. These couple expansion to bony plates at sutures. Craniosynostosis, premature fusion common birth defect (1 in 3000 live births) disrupts often results profoundly abnormal shape. Individuals affected with Boston-type craniosynostosis, an autosomal dominant disorder, bear mutated copy MSX2, homeobox gene thought...
Genetic variation at the chromosome 9p21 risk locus promotes cardiovascular disease; however, it is unclear how or which proteins encoded this contribute to disease. We have previously demonstrated that loss of one candidate gene locus, cyclin-dependent kinase inhibitor 2B (Cdkn2b), in mice vascular SMC apoptosis and aneurysm progression. Here, we investigated role Cdnk2b atherogenesis found a mouse model atherosclerosis, deletion promoted advanced development atherosclerotic plaques...
Congenital heart disease (CHD) has a complex genetic etiology, and recent studies suggest that high penetrance de novo mutations may account for only small fraction of disease. In multi-institutional cohort surveyed by exome sequencing, combining analysis 987 individuals (discovery 59 affected trios control trios, replication 100 singletons 533 unaffected singletons) we observe variation at novel known loci related to specific cardiac malformation the atrioventricular septal defect (AVSD)....
Recent genome wide association studies have identified a number of genes that contribute to the risk for coronary heart disease. One such gene, TCF21, encodes basic-helix-loop-helix transcription factor believed serve critical role in development epicardial progenitor cells give rise artery smooth muscle (SMC) and cardiac fibroblasts. Using reporter gene immunolocalization with mouse human tissues we found vascular TCF21 expression adult is restricted primarily adventitial associated...
Smooth muscle cells (SMC) play a critical role in atherosclerosis. The Aryl hydrocarbon receptor (AHR) is an environment-sensing transcription factor that contributes to vascular development, and has been implicated coronary artery disease risk. We hypothesized AHR can affect atherosclerosis by regulating phenotypic modulation of SMC.We combined RNA-sequencing, chromatin immunoprecipitation followed sequencing, assay for transposase-accessible using vitro assays human SMCs, with single-cell...
Smooth muscle cells (SMCs) transition into a number of different phenotypes during atherosclerosis, including those that resemble fibroblasts and chondrocytes, make up the majority in atherosclerotic plaque. To better understand epigenetic transcriptional mechanisms mediate these cell state changes, how they relate to risk for coronary artery disease (CAD), we have investigated causality function transcription factors at genome-wide associated loci.
Genome wide association studies for coronary artery disease (CAD) have identified a risk locus at 11q22.3. Here, we verify with mechanistic that rs2019090 and PDGFD represent the functional variant gene this locus. Further, FOXC1/C2 transcription factor binding is shown to promote through CAD promoting allele. With single cell transcriptomic histology Pdgfd knockdown in an SMC lineage tracing male atherosclerosis mouse model find promotes expansion, migration, transition of cells...
Atherosclerosis occurs predominantly in arteries and only rarely veins. The goal of this study was to test whether differences the molecular responses venous arterial endothelial cells (ECs) atherosclerotic stimuli might contribute vascular bed susceptibility atherosclerosis. We compared gene expression profiles primary cultured ECs from human saphenous vein (SVEC) coronary artery (CAEC) exposed atherogenic stimuli. In addition identifying differentially expressed genes, we applied...
Pancreatitis is classified into acute pancreatitis (AP) and chronic (CP). Apelin, a small regulatory peptide, the endogenous ligand for APJ receptor. Apelin are expressed in pancreas. The aims of this study were to examine whether apelin influences inflammatory fibrosis responses mice identify mechanisms behind apelin's activities. Supramaximal cerulein induction AP or CP caused significant (P < 0.05) elevations pancreatic expression. Levels declined during recovery phases. In gene-knockout...
Abstract Background Low birth weight is a key indicator for child health, especially concern in low-middle-income countries. However, health and medically-related reforms are being actively implemented some middle-income countries like India. Identifying low (LBW) babies with their determinants across the whole country essential to formulate regional area-specific interventions. The objective of this study was find out burden LBW on residential (rural–urban) divisions Methods present based...
Vascular beds show different propensities for vascular pathologies, yet mechanisms explaining these fundamental differences remain unknown. We sought to build a transcriptomic, cellular, and spatial atlas of human arterial cells across multiple segments understand this phenomenon. found significant cell type-specific segmental heterogeneity. Determinants identity are predominantly encoded in fibroblasts smooth muscle cells, their differentially expressed genes particularly enriched...
TCF21 is a basic helix–loop–helix transcription factor that has recently been implicated as contributing to susceptibility coronary heart disease based on genome wide association studies. In order identify transcriptionally regulated target genes in major relevant cell type, we performed siRNA knockdown of vitro cultured human artery smooth muscle cells and compared the transcriptome siTCF21 versus siCONTROL treated cells. The raw (FASTQ) well processed (BED) data from 3 technical replicates...
Background Globally, undernutrition is the leading cause of mortality among under-five children. Bangladesh and India were in top ten countries world for mortality. The aim study was to investigate nutritional status Bengali Methods Data on 25938 children retrieved from Demographic Health Survey 2017–18 (BDHS) National Family 2015–16 (NFHS-4). Stunting, wasting, underweight thinness considered understand Binary logistic regression used identify associated factors Results Over one-quarter...
Environmental exposure to dioxin has been linked increased myocardial infarction. Smooth muscle cells (SMC) in the coronary vasculature play a critical role atherosclerotic plaque remodeling due their phenotypic plasticity, however, detailed mechanism linking adverse SMC modulation is not well understood.
Msx2 is a mammalian homeodomain protein that expressed during craniofacial development. A proline-to-histidine substitution at residue 148 of human results in an autosomal dominant form craniosynostosis. In this study, both wild-type and mutant were shown to specifically bind DNA sequence previously identified as high-affinity binding site for the related Msx1. co-transfection assays repressed reporter gene transcription dose-dependent but binding-site-independent manner. These provide...
Child undernutrition is a burden and the leading cause of child mortality in low-and middle-income countries like Bangladesh India. Currently, this issue matter great concern, inasmuch as achieving Sustainable Development Goals (SDGs). The study intends to determine factors using single composite index anthropometric failure (CIAF) among Bengali population.Unit level data on 14055 under 5 children were extracted from Demographic Health Survey 2017-18 (BDHS) 4th National Family India...