A5054467454- Acute Ischemic Stroke Management
- Eicosanoids and Hypertension Pharmacology
- Intracerebral and Subarachnoid Hemorrhage Research
- Alcohol Consumption and Health Effects
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer Research and Treatments
- Antibiotic Resistance in Bacteria
- Neurological Disease Mechanisms and Treatments
- Legionella and Acanthamoeba research
- Nitric Oxide and Endothelin Effects
- RNA Research and Splicing
- Stroke Rehabilitation and Recovery
- Cancer-related molecular mechanisms research
- Peripheral Artery Disease Management
- RNA modifications and cancer
Southern Medical University
2024-2025
Guangdong Medical College
2024-2025
Stanford University
2015
Veterans Health Administration
1997
Dallas VA Medical Center
1995
Current guidelines have not recommended an upper age limit for endovascular thrombectomy (EVT) in patients with large vessel occlusion (LVO) stroke. However, elder links to increased risk of poor outcome. This study aimed investigate the efficacy EVT elderly versus non-elderly and determine respective factors Three hundred two consecutive LVO-stroke who underwent were included, we used sensitivity analysis restricted cubic spline define 75 years as inflexion point. Participants thus...
Oxidative stress is a central factor in the pathogenesis of atherosclerosis and potentially exhibits sexual dimorphism. The induction heme oxygenase-1 (HO-1) serves as crucial mechanism against reactive oxygen species toxicity vascular wall, this regulated by promoter (GT)n repeat length. We aim to investigate whether or not HO-1 gene polymorphism associated with occurrence large-artery atherosclerotic (LAA) stroke. consecutively recruited stroke patients, control group comprising age-...
Recent studies indicate that vascular smooth muscle cells generate carbon monoxide (CO) via the action of heme oxygenase (HO). Because adenosine 3',5'-cyclic monophosphate (cAMP) is an important intracellular signaling molecule in regulation cell function, we examined whether this second messenger modulates expression HO and production CO by rat aortic cells. Treatment with membrane-permeable cAMP derivative dibutyryl or compounds increase levels (isoproterenol forskolin) resulted a...
Experiments were performed to examine the effect of ethanol on production nitric oxide from interleukin-1 beta (IL-1 beta)-treated cultured rat aortic smooth muscle cells. Incubation vascular cells with IL-1 resulted in release nitrite and intracellular accumulation L-citrulline. In parallel this, increased inducible synthase (iNOS) mRNA protein. Ethanol (6.5-650 mM) potentiated beta-mediated stimulation iNOS production, appearance protein generation L-citrulline a concentration-dependent...
Flagellates of Naegleria gruberi contain two calmodulins that differ in apparent molecular weight and intracellular location. Calmodulin-1, localized flagella, has an approximately 16,000, the size other protozoan calmodulins, whereas calmodulin-2, cell bodies, is 15,300. Both proteins, purified, are by several criteria, including Ca2+-dependent stimulation calmodulin-dependent cyclic nucleotide phosphodiesterase affinity for antibodies to vertebrate calmodulin. The finding unusual. Since...
TCF21 is a basic helix–loop–helix transcription factor that has recently been implicated as contributing to susceptibility coronary heart disease based on genome wide association studies. In order identify transcriptionally regulated target genes in major relevant cell type, we performed siRNA knockdown of vitro cultured human artery smooth muscle cells and compared the transcriptome siTCF21 versus siCONTROL treated cells. The raw (FASTQ) well processed (BED) data from 3 technical replicates...
Oxidative stress plays a principal role in the pathogenesis of white matter hyperintensities (WMHs). The induction heme oxygenase-1 (
Asymptomatic intracranial hemorrhage (aICH) is common after endovascular thrombectomy (EVT). Collateral circulation could modify the association between aICH with functional outcome and we aimed to investigate impact of systemic inflammation index on 3-month under different collateral circulation.