A5065325193- Genomics and Rare Diseases
- Genetics and Neurodevelopmental Disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Atherosclerosis and Cardiovascular Diseases
- Ubiquitin and proteasome pathways
- Genetic Associations and Epidemiology
- Bone health and treatments
- Cancer-related molecular mechanisms research
- Renal Transplantation Outcomes and Treatments
- RNA Research and Splicing
- Dermatological and Skeletal Disorders
- Psoriasis: Treatment and Pathogenesis
- Medical Imaging and Pathology Studies
- Autoimmune Bullous Skin Diseases
- Hematopoietic Stem Cell Transplantation
- Dermatology and Skin Diseases
- Skin Diseases and Diabetes
- Bone and Dental Protein Studies
- Connective tissue disorders research
- Single-cell and spatial transcriptomics
- Transplantation: Methods and Outcomes
- Tracheal and airway disorders
- Genomic variations and chromosomal abnormalities
- Cancer-related gene regulation
- Immune Cell Function and Interaction
Kunming Children's Hospital
2025
Kunming Medical University
2025
Stanford University
2024
Children's Hospital of Philadelphia
2015-2020
Purpose: To evaluate the long-term efficacy and safety of secukinumab in pediatric patients with generalized pustular psoriasis (GPP).
Vascular beds show different propensities for vascular pathologies, yet mechanisms explaining these fundamental differences remain unknown. We sought to build a transcriptomic, cellular, and spatial atlas of human arterial cells across multiple segments understand this phenomenon. found significant cell type-specific segmental heterogeneity. Determinants identity are predominantly encoded in fibroblasts smooth muscle cells, their differentially expressed genes particularly enriched...
T cell suppression prevents acute cellular rejection but causes life-threatening infections and malignancies. Previously, liver transplant (LTx) in children was associated with the single-nucleotide polymorphism (SNP) rs9296068 upstream of HLA-DOA gene. inhibits B presentation antigen, a potentially novel antirejection drug target. Using archived samples from 122 white pediatric LTx patients (including 77 described previously), we confirmed association between (p = 0.001, odds ratio [OR]...