A5063955794- Bone Metabolism and Diseases
- MicroRNA in disease regulation
- Immune cells in cancer
- Immune Response and Inflammation
- Cardiac Fibrosis and Remodeling
- Cardiac, Anesthesia and Surgical Outcomes
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Acute Myocardial Infarction Research
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Diet and metabolism studies
- Bone health and treatments
- Bone and Joint Diseases
- Cytokine Signaling Pathways and Interactions
- Vascular Procedures and Complications
- Adrenal Hormones and Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Pharmacological Effects of Medicinal Plants
- T-cell and B-cell Immunology
- Eosinophilic Disorders and Syndromes
- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- Genomics, phytochemicals, and oxidative stress
- Signaling Pathways in Disease
Medical University of Vienna
2015-2024
Christian Doppler Laboratory for Thermoelectricity
2021-2024
Ludwig Boltzmann Institute for Digital Health and Prevention
2020
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology
2020
Medizinische Hochschule Hannover
2002-2019
Center for Vascular Biology Research
2018
Vienna General Hospital
2016
Johannes Gutenberg University Mainz
1991
The intestinal epithelium has a high turnover rate and constantly renews itself through proliferation of crypt cells, which depends on insufficiently characterized signals from the microenvironment. Here, we showed that colonic macrophages were located directly adjacent to epithelial cells in mice, where they metabolically supported cell an mTORC1-dependent manner. Specifically, deletion tuberous sclerosis complex 2 (Tsc2) activated mTORC1 signaling protected against colitis-induced damage...
Fibrotic scarring drives the progression of heart failure after myocardial infarction (MI). Therefore, development specific treatment regimens to counteract fibrosis is high clinical relevance. The transcription factor sex-determining region Y box 9 (SOX9) functions as an important regulator during embryogenesis, but recent data point toward additional causal role in organ fibrosis. We show here that SOX9 upregulated scar MI mice. Fibroblast-specific deletion Sox9 ameliorated MI-induced left...
Objectives Bone destruction in rheumatoid arthritis is mediated by osteoclasts (OC), which are derived from precursor cells of the myeloid lineage. The role two monocyte subsets, classical monocytes (expressing CD115, Ly6C and CCR2) non-classical (which CD115 positive, but low CCR2), serving as precursors for OC still elusive. Methods We investigated CCR2 −/− mice, lack circulating monocytes, crossed into hTNFtg mice extent joint damage. analysed subsets K/BxN serum transfer flow cytometry....
Abstract Multinucleated giant cells (MGCs) are implicated in many diseases including schistosomiasis, sarcoidosis and arthritis. MGC generation is energy intensive to enforce membrane fusion cytoplasmic expansion. Using receptor activator of nuclear factor kappa-Β ligand (RANKL) induced osteoclastogenesis model formation, here we report RANKL cellular programming requires extracellular arginine. Systemic arginine restriction improves outcome multiple murine arthritis models its removal...
Dendritic cells (DCs) induce peripheral T cell tolerance, but cell-intrinsic signaling cascades governing their stable tolerogenesis remain poorly defined. Janus Kinase 1 (JAK1) transduces cytokine-receptor signaling, and JAK inhibitors (Jakinibs), including JAK1-specific filgotinib, break inflammatory cycles in autoimmunity. Here, we report heterogeneous DC populations of multiple secondary lymphoid organs that JAK1 promotes tolerance during experimental autoimmune encephalomyelitis (EAE)....
Bone remodelling is a highly dynamic process dependent on the precise coordination of osteoblasts and haematopoietic-cell derived osteoclasts. Changes in core metabolic pathways during osteoclastogenesis, however, are largely unexplored it unknown whether how these processes involved bone homeostasis.
Abstract Bone loss is one of the consequences aging, leading to diseases such as osteoporosis and increased susceptibility fragility fractures therefore considerable morbidity mortality in humans. Here, we identify microRNA‐146a (miR‐146a) an essential epigenetic switch controlling bone with age. Mice deficient miR‐146a show regular development their skeleton. However, while WT mice start lose age, animals continue accrue throughout life span. Increased mass due generation activity...
Osteoclasts (OCs) are myeloid-derived multinucleated cells uniquely able to degrade bone. However, the exact nature of their myeloid precursors is not yet defined.
Between January 1986 and June 1990, recanalization with guide-wire balloon angioplasty (PTCA) was attempted in 509 patients (416 men, 93 women; mean age 57.5 +/- 9 years) chronic coronary artery occlusions. The data recorded were analysed to determine the factors which influenced outcome. intervention initially successful 284 (55.8%; circumflex branch: 50%; right artery: 52%; venous bypass graft: anterior interventricular 64%). success rate markedly reduced if (1) occlusion had persisted for...
Aberrant innate immune responses to the gut microbiota are causally involved in pathogenesis of inflammatory bowel diseases (IBD). The exact triggers and main signaling pathways activating cells how they modulate adaptive immunity IBD is still not completely understood. Here, we report that PI3K/PTEN pathway dendritic enhances IL-6 production a model DSS-induced colitis. This results exacerbated Th1 cell increased mortality DC-specific PTEN knockout (PTEN ΔDC ) animals. Depletion using...
<h3>Background</h3> Micro RNAs (miRNAs) play a crucial role in the regulation of bone metabolism. MiR-146a, an important anti-inflammatory miRNA, was found to negatively impact osteogenesis and regeneration <i>in vitro</i>, by controlling differentiation mesenchymal stem cells. But date miR-146a remodelling, its influence on stability development osteoporosis is not known. <h3>Objectives</h3> The objective this project analysis <h3>Methods</h3> Systemic bone, tibiae femur, wt deficient...
<h3>Background</h3> MicroRNA (MiR-) 146a is a key regulator of the innate immune response and has also been shown to suppress cancer development in myeloid cells., Although late stages arthritis elevated expression miR-146a synovial tissue rheumatoid patients was detected, level this miRNA found be down regulated early disease, but its role inflammatory yet unknown. <h3>Materials Methods</h3> We induced K/BxN serum transfer wild type miR-146a<sup>-/- </sup>mice. As second disease model we...
Long-term results of coronary angioplasty (CAP) were compared between two age-groups patients. Group 1 had 227 patients (158 men, 69 women) with a mean age 70 (65-88) years, group 2 717 (611 106 women), 54 (20-64) years. Unstable angina was more common in than (48.9 vs 37.7%, P < 0.05). Multi-vessel disease present 50.7% those and 41.9% 2. Primary success CAP similar the groups (group 1: 88.1%, 2: 90.5%). The long-term effect at first follow-up angiography 3-4 months after slightly less...
<h3>Introduction</h3> Micro RNAs (miRNAs) play a crucial role in the regulation of bone metabolism. MiR-146a, an important anti-inflammatory miRNA, was found to negatively impact osteogenesis and regeneration <i>in vitro</i>, by controlling differentiation mesenchymal stem cells. But date miR-146a remodelling, its influence on stability development osteoporosis is not known. <h3>Objectives</h3> The objective this project analysis <h3>Methods</h3> Systemic bone, tibiae femur, wt deficient...
<h3>Career situation of first and presenting author</h3> Post-doctoral fellow. <h3>Introduction</h3> Micro RNAs (miRNAs) play a crucial role in the regulation bone metabolism. MiR-146a, an important anti-inflammatory miRNA, was found to negatively impact osteogenesis regeneration <i>in vitro</i>, by controlling differentiation mesenchymal stem cells. But date miR-146a remodelling, its influence on stability development osteoporosis is not known. <h3>Objectives</h3> Our aim analyse function...