A5007631821- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Bone health and treatments
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Bone Metabolism and Diseases
- Neurological Disease Mechanisms and Treatments
- Inflammation biomarkers and pathways
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- IL-33, ST2, and ILC Pathways
- Inflammatory mediators and NSAID effects
University of Zurich
2024
Christian Doppler Laboratory for Thermoelectricity
2022
Medical University of Vienna
2022
Dendritic cells (DCs) induce peripheral T cell tolerance, but cell-intrinsic signaling cascades governing their stable tolerogenesis remain poorly defined. Janus Kinase 1 (JAK1) transduces cytokine-receptor signaling, and JAK inhibitors (Jakinibs), including JAK1-specific filgotinib, break inflammatory cycles in autoimmunity. Here, we report heterogeneous DC populations of multiple secondary lymphoid organs that JAK1 promotes tolerance during experimental autoimmune encephalomyelitis (EAE)....
Bone remodelling is a highly dynamic process dependent on the precise coordination of osteoblasts and haematopoietic-cell derived osteoclasts. Changes in core metabolic pathways during osteoclastogenesis, however, are largely unexplored it unknown whether how these processes involved bone homeostasis.
Abstract Multiple sclerosis (MS) is characterized by neuroinflammation, oxidative stress, iron toxicity and mitochondrial dysfunction. Reactive oxygen species (ROS) produced mononuclear phagocytes (MPs) are widely held to drive tissue damage, yet the specific roles of central nervous system (CNS)- resident versus CNS-invading MPs remain unclear. Here, combining single-cell profiling with conditional gene targeting, we systematically dissected interfered ROS production across CNS in a...
Regulatory T (Treg) cells are critical for maintaining peripheral tolerance and preventing autoimmunity. Treg cell depletion or dysfunction rapidly results in fatal multiorgan inflammation linked to unrestrained effector expansion, but the cytokine network underlying immunopathology, its direct cellular mediators, remain elusive. Here, we combined gene targeting, fate-mapping tools, high-dimensional cytometry identify helper (TH) cell-derived cytokines responding that execute inflammatory...
Summary Granulocyte-macrophage colony-stimulating factor (GM-CSF) has a non-redundant role in the emergence and maintenance of alveolar macrophages (AMs). However, its developmental steady-state myelopoiesis outside lung is largely unexplored. Scanning through developing tissues using Fate-map reporter GM-CSF mouse strain, we discovered that was produced by type 2 innate lymphoid cells (ILC2s) submandibular sublingual salivary gland (SG) during postnatal development. producing ILC2s foster...