A5086812689- T-cell and B-cell Immunology
- Single-cell and spatial transcriptomics
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- Immune cells in cancer
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Myasthenia Gravis and Thymoma
- Long-Term Effects of COVID-19
- Neuroinflammation and Neurodegeneration Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Immune Response and Inflammation
- Ideological and Political Education
- vaccines and immunoinformatics approaches
- Cancer Immunotherapy and Biomarkers
- Infant Nutrition and Health
- Antifungal resistance and susceptibility
- Neonatal Respiratory Health Research
- Multiple Sclerosis Research Studies
University of Zurich
2020-2024
UCB Pharma (United Kingdom)
2017
Abstract Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system underpinned by partially understood genetic risk factors and environmental triggers their undefined interactions 1,2 . Here we investigated peripheral immune signatures 61 monozygotic twin pairs discordant for MS to dissect influence predisposition factors. Using complementary multimodal high-throughput high-dimensional single-cell technologies in conjunction with data-driven computational...
Abstract Interleukin-23 (IL-23) is a proinflammatory cytokine mainly produced by myeloid cells that promotes tumor growth in various preclinical cancer models and correlates with adverse outcomes. However, as to how IL-23 fuels unclear. Here, we found tumor-associated macrophages be the main source of mouse human microenvironments. Among IL-23-sensing cells, identified subset tumor-infiltrating regulatory T (T reg ) display highly suppressive phenotype across tumors. The use three solid...
Abstract Macrophages are involved in immune defense, organogenesis and tissue homeostasis. contribute to the different phases of mammary gland remodeling during development, pregnancy involution postlactation. Less is known about dynamics macrophages lactation stage. Here, we describe a macrophage population present mice. By multiparameter flow cytometry single-cell RNA sequencing, identified lactation-induced CD11c + CX3CR1 Dectin-1 (liMac) that was distinct from two resident F4/80 hi lo...
Abstract Myasthenia gravis (MG) is an autoimmune disease characterized by impaired neuromuscular signaling due to autoantibodies targeting the acetylcholine receptor. Although its auto-antigens and effector mechanisms are well defined, cellular molecular drivers underpinning MG remain elusive. Here, we employed high-dimensional single-cell mass spectral cytometry of blood thymus samples from patients in combination with supervised unsupervised machine-learning tools gain insight into immune...
Comorbidities are risk factors for development of severe coronavirus disease 2019 (COVID-19). However, the extent to which an underlying comorbidity influences immune response acute respiratory syndrome 2 remains unknown.Our aim was investigate complex interrelations comorbidities, response, and patient outcome in COVID-19.We used high-throughput, high-dimensional, single-cell mapping peripheral blood leukocytes algorithm-guided analysis.We discovered characteristic signatures associated not...
Abstract The range of vaccines developed against severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) provides a unique opportunity to study immunization across different platforms. In single-center cohort, we analyzed the humoral and cellular immune compartments following five disease 2019 (COVID-19) spanning three technologies (adenoviral, mRNA inactivated virus) administered in 16 combinations. For adenoviral inactivated-virus vaccines, heterologous combinations were generally...
The Swiss Young Immunologists Society (SYIS) was established in September 2020 under the umbrella of young European Federation Immunology Societies (yEFIS) [1, 2]. overarching aim this effort to strengthen networking opportunities as well increase visibility immunologists during challenging times surrounding COVID-19 pandemic. Over past 2.5 years, SYIS has successfully evolved into a formal and society, continuously engaging recruiting new members. Through partnership with for Allergology...
Regulatory T (Treg) cells are critical for maintaining peripheral tolerance and preventing autoimmunity. Treg cell depletion or dysfunction rapidly results in fatal multiorgan inflammation linked to unrestrained effector expansion, but the cytokine network underlying immunopathology, its direct cellular mediators, remain elusive. Here, we combined gene targeting, fate-mapping tools, high-dimensional cytometry identify helper (TH) cell-derived cytokines responding that execute inflammatory...
Abstract Aging, and age-related physiological changes, have been heavily implicated in declining immune functions. Many of these changes to the system include myeloid subsets, which poorly studied so far. Myeloid cells play crucial roles acute infection are involved antigen presentation adaptive system. Consequently, deciphering mechanisms holds great potential for targeting immunity. Here, we developed a model map age related phenotypic compartment all immunologically relevant murine...
Abstract Myasthenia gravis is a rare but archetypic autoimmune disease that characterized by the autoantibody-mediated disruption of neuromuscular junction leading to skeletal muscle weakness. Immunomodulatory treatment options for patients are largely unspecific, include suppression entire immune compartment and often accompanied severe side effects. In order identify novel biomarkers more targeted effective therapeutic approaches, we combined high-dimensional mass flow cytometry with...
Abstract Several vaccines have been found effective against COVID-19, usually administered in homologous regimens, with the same vaccine used for prime and boost doses. However, recent studies demonstrated improved protection via heterologous mix-and-match COVID-19 combinations, a direct comparison among these regimens is needed to identify best employment strategies. Here, we show single-cohort of changes humoral cellular immune compartments following five different spanning three...