A5043504505- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Immunotherapy and Immune Responses
- Chronic Lymphocytic Leukemia Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Immunodeficiency and Autoimmune Disorders
- Alzheimer's disease research and treatments
- Autoimmune and Inflammatory Disorders Research
- Immune cells in cancer
- Eosinophilic Esophagitis
- Immune Response and Inflammation
- Acute Lymphoblastic Leukemia research
- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- interferon and immune responses
- Single-cell and spatial transcriptomics
- Tryptophan and brain disorders
University of Zurich
2019-2024
HUN-REN Institute of Experimental Medicine
2023
Highlights•cGAS in cancer and STING host cells are minimal requirements to activate CD8+ T cells•Cancer transfer cGAMP myeloid the TME that make STING-dependent IFN-I•Cancer-cell-intrinsic cGAS improves tumor immunogenicity response therapySummarySensing of cytoplasmic DNA by cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) results production dinucleotide consecutive activation stimulator interferon genes (STING) followed type I (IFN). Although contain...
Abstract Interleukin-23 (IL-23) is a proinflammatory cytokine mainly produced by myeloid cells that promotes tumor growth in various preclinical cancer models and correlates with adverse outcomes. However, as to how IL-23 fuels unclear. Here, we found tumor-associated macrophages be the main source of mouse human microenvironments. Among IL-23-sensing cells, identified subset tumor-infiltrating regulatory T (T reg ) display highly suppressive phenotype across tumors. The use three solid...
Metabolic-associated fatty liver disease (MAFLD) is a spectrum of clinical manifestations ranging from benign steatosis to cirrhosis. A key event in the pathophysiology MAFLD development nonalcoholic steatohepatitis (NASH), which can potentially lead fibrosis and hepatocellular carcinoma, but triggers MAFLD-associated inflammation are not well understood. We have observed that lipid accumulation hepatocytes induces expression ligands specific activating immune receptor NKG2D. Tissue-resident...
Group 1 innate lymphoid cells (ILCs) comprising circulating natural killer (cNK) and tissue-resident ILC1s are critical for host defense against pathogens tumors. Despite a growing understanding of their role in homeostasis disease, the ontogeny group ILCs remains largely unknown. Here, we used fate mapping single-cell transcriptomics to comprehensively investigate origin turnover murine ILCs. Whereas cNK continuously replaced throughout life, uncovered tissue-dependent development ILC1s. A...
Group 1 innate lymphoid cells (ILCs) encompass NK and ILC1s, which have non-redundant roles in host protection against pathogens cancer. Despite their circulating nature, can establish residency selected tissues during ontogeny, forming a distinct functional subset. The mechanisms that initiate, maintain, regulate the conversion of into tissue-resident (trNK) are currently not well understood. Here, we identify autocrine transforming growth factor-β (TGF-β) as cell-autonomous driver for cell...
Abstract There is growing evidence that the adaptive immune system and neurodegenerative Alzheimer’s disease (AD) are intertwined in multiple ways. Recent studies have reported alterations of early AD stages, such as preclinical mild cognitive impairment (MCI) due to AD. However, identity specific antigenic targets whether respective response beneficial or detrimental during progression still open questions. Herein, we describe cross-sectional analyses blood cerebrospinal fluid from three...