A5039004481- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Neuroblastoma Research and Treatments
- Diabetes and associated disorders
- Neuroendocrine Tumor Research Advances
- Adipokines, Inflammation, and Metabolic Diseases
- Lung Cancer Research Studies
- Hematopoietic Stem Cell Transplantation
- Diet and metabolism studies
- Genetic factors in colorectal cancer
- Acute Lymphoblastic Leukemia research
- CAR-T cell therapy research
- Cancer Cells and Metastasis
- Toxin Mechanisms and Immunotoxins
- IL-33, ST2, and ILC Pathways
- T-cell and B-cell Immunology
- Gastric Cancer Management and Outcomes
- Phytoplasmas and Hemiptera pathogens
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Pancreatic function and diabetes
- Cancer-related molecular mechanisms research
- Caveolin-1 and cellular processes
Rudjer Boskovic Institute
2020-2025
University of Rijeka
2018-2024
Croatian Institute of Transfusion Medicine
2022
Metabolic dysfunction-associated steatotic liver disease (MASLD) is an increasingly common complication of obesity, affecting over a quarter the global adult population. A key event in pathophysiology MASLD development metabolic-associated steatohepatitis (MASH), which greatly increases chances developing cirrhosis and hepatocellular carcinoma. The underlying cause MASH multifactorial, but accumulating evidence indicates that inflammatory process hepatic microenvironment typically follows...
Metabolic-associated fatty liver disease (MAFLD) is a spectrum of clinical manifestations ranging from benign steatosis to cirrhosis. A key event in the pathophysiology MAFLD development nonalcoholic steatohepatitis (NASH), which can potentially lead fibrosis and hepatocellular carcinoma, but triggers MAFLD-associated inflammation are not well understood. We have observed that lipid accumulation hepatocytes induces expression ligands specific activating immune receptor NKG2D. Tissue-resident...
Despite major therapeutic advances in the treatment of acute lymphoblastic leukemia (ALL), resistances and long-term toxicities still pose significant challenges. Cyclins their associated cyclin-dependent kinases are one focus cancer research when looking for targeted therapies. We discovered cyclin C as a key factor B-ALL development maintenance. While is non-essential normal hematopoiesis, CcncΔ/Δ BCR::ABL1+ cells fail to elicit mice. RNA sequencing experiments revealed p53 pathway...
Epidermal growth factor receptor (EGFR) expression is commonly upregulated in sporadic colorectal cancer (CRC) and its high associated with poor prognosis patients CRC. CA‑SSR1 a dinucleotide CA repeat of the <em>EGFR</em> gene that can modulate transcription potential target mismatch repair machinery tumours microsatellite instability (MSI). In present study, 160 colon samples were analysed for polymorphism MSI status. Additionally, mRNA protein levels tumour centre invasive front, compared...
MicroRNAs (miRNAs) are critical post-transcriptional gene regulators and their involvement in sporadic colon cancer (CRC) tumorigenesis has been confirmed. In this study we investigated differences miRNA expression microsatellite stable (MSS/EMAST-S), unstable marked by high elevated alterations at selected tetranucleotide repeats (MSS/EMAST-H), (MSI-H/EMAST-H) tumor subgroups as well tumors with different clinicopathologic characteristics. An RT-qPCR analysis of was carried out on 45...