A5076026112- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Endoplasmic Reticulum Stress and Disease
- Ubiquitin and proteasome pathways
- Biomedical Ethics and Regulation
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- Signaling Pathways in Disease
- Mesenchymal stem cell research
- Cerebrospinal fluid and hydrocephalus
- Multiple Sclerosis Research Studies
- Immune Cell Function and Interaction
Swiss Institute for Regenerative Medicine
2023-2024
University of Zurich
2021-2024
ETH Zurich
2022-2024
Stem cell therapy is an emerging treatment paradigm for stroke patients with remaining neurological deficits. While allogeneic transplants overcome the manufacturing constraints of autologous grafts, they can be rejected by recipient's immune system, which identifies foreign cells through human leukocyte antigen (HLA) system. The heterogeneity HLA molecules in population would require a very high number lines, may still inadequate rare genetic HLAs. Here, we outline key progress engineering...
Fast and minimally invasive approaches for early diagnosis of Alzheimer's disease (AD) are highly anticipated. Evidence adaptive immune cells responding to cerebral β-amyloidosis has raised the question whether markers could be used as proxies β-amyloid accumulation in brain.
Group 1 innate lymphoid cells (ILCs) comprising circulating natural killer (cNK) and tissue-resident ILC1s are critical for host defense against pathogens tumors. Despite a growing understanding of their role in homeostasis disease, the ontogeny group ILCs remains largely unknown. Here, we used fate mapping single-cell transcriptomics to comprehensively investigate origin turnover murine ILCs. Whereas cNK continuously replaced throughout life, uncovered tissue-dependent development ILC1s. A...
ABSTRACT Fast and minimally invasive approaches for early, preclinical diagnosis of neurodegenerative Alzheimer’s disease (AD) are highly anticipated. Evidence adaptive immune cells responding to cerebral β-amyloidosis, one the pathological hallmarks AD, has raised question whether markers could be used as proxies β-amyloid accumulation in brain. Here, we deploy multidimensional mass cytometry combined with unbiased machine learning techniques immunophenotype peripheral blood mononuclear...
Efficient myelination supports nerve conduction and axonal health throughout life. In the central nervous system, oligodendrocytes (OLs) carry out this demanding anabolic duty in part through biosynthetic pathways controlled by mTOR. We identify Ral GTPases as critical regulators of mouse spinal cord myelin maintenance. Ablation (RalA, RalB) OL-lineage cells impairs timely onset radial growth developmental myelination, accompanied increased endosomal/lysosomal abundance. Further...
Abstract There is growing evidence that the adaptive immune system and neurodegenerative Alzheimer’s disease (AD) are intertwined in multiple ways. Recent studies have reported alterations of early AD stages, such as preclinical mild cognitive impairment (MCI) due to AD. However, identity specific antigenic targets whether respective response beneficial or detrimental during progression still open questions. Herein, we describe cross-sectional analyses blood cerebrospinal fluid from three...
Fast and minimally invasive approaches for early, preclinical diagnosis of neurodegenerative Alzheimer’s disease (AD) are highly anticipated. Evidence adaptive immune cells responding to cerebral β-amyloidosis, one the pathological hallmarks AD, has raised question whether markers could be used as proxies β-amyloid accumulation in brain. Here, we deploy multidimensional mass cytometry combined with unbiased machine learning techniques immunophenotype peripheral blood mononuclear from study...