A5048554185- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Barrier Structure and Function Studies
- Neurological Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Nutritional Studies and Diet
- Advanced Neuroimaging Techniques and Applications
- Extracellular vesicles in disease
- Health Systems, Economic Evaluations, Quality of Life
- Parathyroid Disorders and Treatments
- Mesenchymal stem cell research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Neurogenesis and neuroplasticity mechanisms
- Diabetes Treatment and Management
University of Zurich
2018-2024
Swiss Institute for Regenerative Medicine
2020-2024
Biogen (Switzerland)
2022
ETH Zurich
2020
Abstract Introduction Global estimates on numbers of persons in early stages Alzheimer's disease (AD), including prodromal and preclinical, are lacking, yet needed to inform policy decisions preventive measures planning for future therapies targeting AD pathology. Methods We synthesized the literature prevalence across continuum derived a model estimating number persons, stratified by 5‐year age groups, sex, stage (AD dementia, AD, preclinical AD). Results The global with were estimated at...
<b><i>Background:</i></b> Strong genetic and epidemiological evidence points to a crucial role of the immune system in development Alzheimer disease (AD). CD3+ T lymphocytes have been described brains postmortem AD patients transgenic models AD-like cerebral amyloidosis tau pathology. However, occurrence cells is still controversial; furthermore, relationship between hallmarks pathology (amyloid plaques neurofibrillary tangles) remains be established....
Fast and minimally invasive approaches for early diagnosis of Alzheimer's disease (AD) are highly anticipated. Evidence adaptive immune cells responding to cerebral β-amyloidosis has raised the question whether markers could be used as proxies β-amyloid accumulation in brain.
The distinct organization of the brain's vasculature ensures adequate delivery oxygen and nutrients during development adulthood. Acute chronic pathological changes vascular system have been implicated in many neurological disorders including stroke dementia. Here, we describe a fast, automated method that allows highly reproducible, quantitative assessment parameters their based on open source software Fiji (ImageJ). In particular, developed practical guide to reliably measure aspects...
Background: Synaptic dysfunction plays an important role in Alzheimer′s disease (AD) and is emerging imaging fluid biomarker. Here, we aimed to assess the regional expression of synaptic vesicle glycoprotein 2A (SV2A) brain extracellular vesicles AD patients its associations with APOE e4 allele, amyloid-&#61538, tau pathologies, other markers. Methods: Mass spectrometry-based synaptosome proteomics was performed on brain-derived (BdEVs) isolated from frontal cortex 17 4 NCs....
Abstract An impairment of amyloid β-peptide (Aβ) clearance is suggested to play a key role in the pathogenesis sporadic Alzheimer’s disease (AD). Amyloid degradation mediated by various mechanisms including fragmentation enzymes like neprilysin, matrix metalloproteinases (MMPs) and recently identified amyloidolytic activity β-site precursor protein cleaving enzyme 1 (BACE1). BACE1 cleavage Aβ40 Aβ42 results formation common Aβ34 intermediate which was found elevated cerebrospinal fluid...
Abstract In the brain capillaries, endothelial cells, pericytes, astrocytes and microglia form a structural functional complex called neurovascular unit (NVU) which is critically involved in maintaining neuronal homeostasis. present study, we applied comprehensive immunohistochemical approach to investigate alterations NVU across different Alzheimer's disease (AD) neuropathological stages. Post‐mortem human cortical hippocampal samples derived from AD patients non‐demented elderly control...
ABSTRACT Fast and minimally invasive approaches for early, preclinical diagnosis of neurodegenerative Alzheimer’s disease (AD) are highly anticipated. Evidence adaptive immune cells responding to cerebral β-amyloidosis, one the pathological hallmarks AD, has raised question whether markers could be used as proxies β-amyloid accumulation in brain. Here, we deploy multidimensional mass cytometry combined with unbiased machine learning techniques immunophenotype peripheral blood mononuclear...
Abstract There is growing evidence that the adaptive immune system and neurodegenerative Alzheimer’s disease (AD) are intertwined in multiple ways. Recent studies have reported alterations of early AD stages, such as preclinical mild cognitive impairment (MCI) due to AD. However, identity specific antigenic targets whether respective response beneficial or detrimental during progression still open questions. Herein, we describe cross-sectional analyses blood cerebrospinal fluid from three...
Fast and minimally invasive approaches for early, preclinical diagnosis of neurodegenerative Alzheimer’s disease (AD) are highly anticipated. Evidence adaptive immune cells responding to cerebral β-amyloidosis, one the pathological hallmarks AD, has raised question whether markers could be used as proxies β-amyloid accumulation in brain. Here, we deploy multidimensional mass cytometry combined with unbiased machine learning techniques immunophenotype peripheral blood mononuclear from study...