A5015033223- Alzheimer's disease research and treatments
- Extracellular vesicles in disease
- Mitochondrial Function and Pathology
- Advanced MRI Techniques and Applications
- Advanced Chemical Sensor Technologies
- Salivary Gland Disorders and Functions
- Genetic Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Advanced Proteomics Techniques and Applications
- Adipose Tissue and Metabolism
- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
- Neurotransmitter Receptor Influence on Behavior
- Cellular transport and secretion
University of Fribourg
2022-2025
University of Lausanne
2025
University Hospital of Lausanne
2024
Swiss Integrative Center for Human Health
2022
Indian Institute of Science Bangalore
2021
Tauopathies are neurodegenerative disorders characterized by abnormal tau aggregation, with primary 3R (e.g., Picks disease, PiD) and 4R progressive supranuclear palsy, PSP) variants posing a significant diagnostic challenge. Here, we examined brain-derived extracellular vesicles (BD-EVs) isolated from the prefrontal cortex of PiD (3R), PSP (4R), non-demented controls (CTRL) to determine if these reflect disease-specific proteomic signatures. We found that while pathology does not...
Background: Synaptic dysfunction plays an important role in Alzheimer′s disease (AD) and is emerging imaging fluid biomarker. Here, we aimed to assess the regional expression of synaptic vesicle glycoprotein 2A (SV2A) brain extracellular vesicles AD patients its associations with APOE e4 allele, amyloid-&#61538, tau pathologies, other markers. Methods: Mass spectrometry-based synaptosome proteomics was performed on brain-derived (BdEVs) isolated from frontal cortex 17 4 NCs....
Abstract Background Tau is an intracellular protein that plays a crucial role in stabilizing microtubules. However, it can aggregate into various forms under pathological conditions and be secreted the brain parenchyma. While consequences of tau aggregation within neurons have been extensively studied, effects extracellular paired helical filaments (ePHF-tau) on astrocytes are still poorly understood. Methods This study examined effect human ePHF-tau (2N4R) primary cultures rat neuroglia,...
Abstract Forced swim test (FST) and tail suspension (TST) are commonly used behavioral tests for screening antidepressant drugs with a high predictive validity. These have also proved useful to assess the non-motor symptoms in animal models of movement disorders such as Parkinson’s disease Huntington’s disease. Manual analysis FST TST is time-consuming exercise has large observer-to-observer variability. Automation alleviates these concerns, but there no easy-to-use open-source tools...
Background: Alzheimer’s disease (AD) remains to date an incurable with a long asymptomatic phase. Early diagnosis in peripheral biofluids has emerged as key for identifying subjects at risk and developing therapeutics preventative approaches. Objective: We apply proteomics discovery identify salivary diagnostic biomarkers AD, which are suitable self-sampling longitudinal biomonitoring during aging. Methods: 57 participants were recruited the study categorized into Cognitively normal (CNh) (...
Abstract Background Tauopathies encompass a spectrum of neurodegenerative disorders which are marked by the pathological aggregation tau protein into paired helical filaments (PHF-tau), neurofibrillary tangles (NFTs) and Glial-fibrillary (GFTs). These aggregates impair cellular, mitochondrial, synaptic functions. The emergence extracellular (ePHF-tau), featuring myriad isoforms phosphorylation states, presents challenge in comprehending its nuanced effects on neural cells, particularly...
<title>Abstract</title> <bold>Background</bold> Tauopathies encompass a spectrum of neurodegenerative disorders which are marked by the pathological aggregation tau protein into paired helical filaments (PHF-tau), neurofibrillary tangles (NFTs) and Glial-fibrillary (GFTs). These aggregates impair cellular, mitochondrial, synaptic functions. The emergence extracellular (ePHF-tau), featuring myriad isoforms phosphorylation states, presents challenge in comprehending its nuanced effects on...
Abstract Smell and taste disorders are recognized as frequent, often the only, signs occurring in early phase of SARS-Cov-2 infection many cases perdure post-viral symptoms. This evidence raised a general reconsideration chemosensory deficits, further suggesting that their appearance can be considered discriminative predictive tool to detect COVID-19 cases. In this study, encompassing first second pandemic wave, participants estimated olfactory gustatory sensitivity, plus they were...