A5004901117- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Mycobacterium research and diagnosis
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Urinary Bladder and Prostate Research
- Cytokine Signaling Pathways and Interactions
- Inflammatory mediators and NSAID effects
- SARS-CoV-2 and COVID-19 Research
- Cancer, Stress, Anesthesia, and Immune Response
- Sperm and Testicular Function
- COVID-19 Clinical Research Studies
- Hormonal and reproductive studies
- Urologic and reproductive health conditions
- Prostate Cancer Diagnosis and Treatment
- Immune cells in cancer
- Reproductive tract infections research
- Nanoplatforms for cancer theranostics
- Genital Health and Disease
- Cancer Immunotherapy and Biomarkers
- Immunodeficiency and Autoimmune Disorders
- vaccines and immunoinformatics approaches
- Long-Term Effects of COVID-19
- Monoclonal and Polyclonal Antibodies Research
- Galectins and Cancer Biology
Universidad Nacional de Córdoba
2012-2023
Consejo Nacional de Investigaciones Científicas y Técnicas
2011-2023
Research Centre in Biological Chemistry of Córdoba
2022-2023
Centro Científico Tecnológico - Córdoba
2012-2021
Cordoba University
2016
Ghent University
2011
Joslin Diabetes Center
2002
Centre National de la Recherche Scientifique
2002
Institut de Biologie Moléculaire et Cellulaire
2002
Inserm
2002
Arthritis in the K/BxN mouse model is provoked by pathogenic antibodies (Abs) directed against a ubiquitously expressed protein, glucose-6-phosphate isomerase (GPI). To begin dissecting repertoire of arthritogenic immunoglobulins (Igs) model, and to provide basis for comparison with RA patientswe have generated anti-GPI monoclonal Abs (mAbs) from spontaneously activated B cells lymphoid organs arthritic mice. cell clones specificities were present at extraordinarily high frequencies spleen,...
Trisomy 21 (T21) causes Down syndrome (DS), a condition characterized by high prevalence of autoimmune disorders. However, the molecular and cellular mechanisms driving this phenotype remain unclear. Building upon our previous finding that T cells from people with DS show increased expression interferon (IFN)-stimulated genes, we have completed comprehensive characterization peripheral cell compartment in adults without conditions. CD8+ are depleted naïve subsets enriched for differentiated...
The aging process is accompanied by altered immune system functioning and an increased risk of infection. Dendritic cells (DCs) are antigen-presenting that play a key role in both adaptive innate immunity, but how affects DCs their influence on immunity has not been thoroughly established. Here we examined the function conventional (cDCs) old mice after TLR7 stimulation, focusing ability to cross-prime CD8+ T cells. Using polyU, synthetic ssRNA analog, as ligand OVA antigen (Ag) model, found...
BACKGROUND: The relationship between chronic prostatitis and fertility has been controversial for many years. We have previously shown the presence of a cellular autoimmune response against prostate antigens in group patients. Our main goal was to investigate whether (either caused by an infection or gland) could deleterious effect on semen quality. METHODS: Forty-four patients diagnosed as suffering from were included divided into groups according and/or antigens. Healthy normal individuals...
Abstract Although an eruption of information on the role Toll-like receptor 4 (TLR4), main for bacterial lipopolysaccharide, in activating macrophages and dendritic cells has emerged, very little is known about TLR4 present epithelial from sterile environments like tumors. The goal this work was to investigate consequences activation tumor two different animal models cancer: Dunning rat prostate cancer B16 murine melanoma models. We show that (a) signaling cell lines vitro modifies outgrowth...
Dendritic cells (DC) have the potential to control outcome of autoimmunity by modulating immune response. In this study, we tested ability Fasciola hepatica total extract (TE) induce tolerogenic properties in CpG-ODN (CpG) maturated DC, then evaluate therapeutic these diminish inflammatory response collagen induced arthritis (CIA). DBA/1J mice were injected with TE plus CpG treated DC (T/C-DC) pulsed bovine II (CII) between two immunizations CII and clinical scores CIA determined. The levels...
Abstract BACKGROUND Chronic inflammation has been postulated to be an important driving force prostate carcinoma. Toll‐like receptors (TLRs) compose a family of mainly expressed on immune cells. Recently, functional TLRs have shown also in numerous cancer cells, but their significance only recently begun explored. The purpose this study was investigate the putative role TLR4 expression METHODS To determine if there is association between and malignancy tumor, 35 carcinoma samples showing...
The immune response against cancer generated by type-I-interferons (IFN-1) has recently described. Exogenous and endogenous IFN-/β have an important role in surveillance control of tumor development. In addition, IFN-1s emerged as novel DAMP for the consecutive events connecting innate adaptive immunity they also been postulated essential requirement induction immunogenic cell death (ICD). this context, Photodynamic therapy (PDT) previously linked to ICD. PDT consists administration a...
Abstract Despite the prevalence of prostate disease, little is known about immunobiology and its contribution to disease. The main goal this work was investigate how epithelial cells deal with inflammatory stimuli. To aim, we stimulated a rat cell line [metastasis-lung (MAT-LU)] or primary lipopolysaccharide (LPS). Prostate constitutively express significant levels Toll-like receptor 4 (TLR4) CD14 mRNA. TLR2 transcription could also be demonstrated, suggesting that these recognize broader...
Abstract We have recently proposed an autoimmune etiology in ∼35% of chronic nonbacterial prostatitis patients, the most frequent form observed, because they exhibit IFN-γ-secreting lymphocytes specific to prostate Ags. Interestingly, this particular group but not rest also presented striking abnormalities their semen quality. In work, we use experimental animal model on Wistar rats developed our laboratory investigate when, where, and how sperm cells from individuals are being damaged. As a...
Toll-like receptor (TLR) ligands may be a valuable tool to promote antitumor responses by reinforcing immunity. In addition their expression in immune cells, functional TLRs are also expressed many cancer but significance has been controversial. this study, we examined the action of TLR on tumor pathophysiology as result direct cell effects. B16 murine melanoma cells were stimulated vitro with TLR4 ligand (LPS-B16) prior inoculation into TLR4-deficient mice (Tlr4 (lps-del)). Under such...
Abstract ssRNA can interact with dendritic cells (DCs) through binding to TLR7, inducing secretion of proinflammatory cytokines and type I IFN. Triggering TLR7 enhances cross-priming CD8+ T cells, which requires cross-presentation exogenous Ag DCs. However, how TLR triggering affect is still not clear. Using OVA as an model, we observed that stimulation in DCs by polyuridylic acid (polyU), a synthetic analog, generates strong specific cytotoxic response C57BL/6 mice. PolyU stimulate CD8α+...
P-glycoprotein (P-gp) is a membrane protein associated with multidrug resistance (MDR) due to its key role in mediating the traffic of chemotherapeutic drugs outside cancer cells, leading cellular response that hinders efforts toward successful therapy. With aim finding agents circumvent MDR phenotype mediated by P-gp, 15 compounds isolated from native and naturalized plants Argentina were screened. Among these, non-cytotoxic lignan (±) pinoresinol successfully restored sensitivity...
Abstract The range of vaccines developed against severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) provides a unique opportunity to study immunization across different platforms. In single-center cohort, we analyzed the humoral and cellular immune compartments following five disease 2019 (COVID-19) spanning three technologies (adenoviral, mRNA inactivated virus) administered in 16 combinations. For adenoviral inactivated-virus vaccines, heterologous combinations were generally...
An important challenge in cancer immunotherapy is to expand the number of patients that benefit from immune checkpoint inhibitors (CI), a fact has been related pre-existence an efficient antitumor response. Different strategies are being proposed promote tumor immunity and be used combined therapies with CI. Recently, we reported intratumoral administration naked poly A:U, dsRNA mimetic empirically early clinical trials some success, delays growth prolongs mice survival several murine...
Abstract Background Characterization of breast cancer (BC) through the determination conventional markers such as ER, PR, HER2, and Ki67 has been useful a predictive therapeutic tool. Also, assessment tumor-infiltrating lymphocytes proposed an important prognostic aspect to be considered in certain BC subtypes. However, there is still need identify additional biomarkers that could add precision distinguishing response individual patients. To this end, we focused expression interferon...
Although Chlamydia infections are widespread throughout the world, data about immunopathogenesis of genitourinary tract in males very limited. In present work we an vitro model male genital tract-derived epithelial cells, more precisely prostate cells (PEC), to analyze if they susceptible and able respond muridarum infection. Our results demonstrate that rat PEC C. infection this pathogen by up-regulating different proinflammatory cytokine chemokine genes could participate recruitment local...