A5042216303- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- interferon and immune responses
- Epigenetics and DNA Methylation
- Pharmacology and Obesity Treatment
- Ion Channels and Receptors
- Monoclonal and Polyclonal Antibodies Research
- Inflammasome and immune disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Cytokine Signaling Pathways and Interactions
- Pluripotent Stem Cells Research
- Renal and related cancers
- Cardiac Valve Diseases and Treatments
- Cell Adhesion Molecules Research
- Asthma and respiratory diseases
- Genetic factors in colorectal cancer
- Pain Mechanisms and Treatments
- Acute Lymphoblastic Leukemia research
- CRISPR and Genetic Engineering
- Immune Response and Inflammation
- Muscle Physiology and Disorders
- Ion channel regulation and function
- Digestive system and related health
Institut de génétique et de biologie moléculaire et cellulaire
2013-2023
Centre National de la Recherche Scientifique
2002-2023
Université de Strasbourg
2013-2023
Inserm
2002-2023
Institut de Biologie Moléculaire et Cellulaire
2002
Arthritis in the K/BxN mouse model is provoked by pathogenic antibodies (Abs) directed against a ubiquitously expressed protein, glucose-6-phosphate isomerase (GPI). To begin dissecting repertoire of arthritogenic immunoglobulins (Igs) model, and to provide basis for comparison with RA patientswe have generated anti-GPI monoclonal Abs (mAbs) from spontaneously activated B cells lymphoid organs arthritic mice. cell clones specificities were present at extraordinarily high frequencies spleen,...
By binding to Notch target genes, Ikaros shuts off the expression of these genes in T cells and prevents development cell acute lymphoblastic leukemia.
Background and Purpose Valvular heart disease (VHD) is highly prevalent in industrialized countries. Chronic use of anorexigens, amphetamine or ergot derivatives targeting the 5‐HT system associated with VHD. Here, we investigated contribution receptors a model valve degeneration induced by nordexfenfluramine, main metabolite dexfenfluramine benfluorex. Experimental Approach Nordexfenfluramine was infused chronically (28 days) mice ((WT transgenic Htr 2B ‐/‐ , 2A 2B/2A ) to induce mitral...
The transcriptional regulators that drive regulatory T (Treg) cell development and function remain partially understood. Helios (Ikzf2) Eos (Ikzf4) are closely-related members of the Ikaros family transcription factors. They highly expressed in CD4+ Treg cells functionally important for biology, as mice deficient either or susceptible to autoimmune diseases. However, it remains unknown if these factors exhibit specific redundant functions cells. Here we show with germline deletions both...
The intestine-specific caudal-related homeobox gene-2 (CDX2) gene, while being a tumor suppressor in the gut, is ectopically expressed large proportion of acute leukemia and associated with poor prognosis. Here, we report that turning on human CDX2 expression hematopoietic lineage mice induces monoblastic leukemia, characterized by decrease erythroid lymphoid cells at benefit immature monocytic granulocytic cells. One highly stimulated genes leukemic bone marrow was BMP activin...
The cell composition of bronchoalveolar lavage fluid (BAL) is an important indicator airway inflammation. It commonly determined by cytocentrifuging leukocytes on slides, then staining, identifying, and counting them as eosinophils, neutrophils, macrophages, or lymphocytes according to morphological criteria under light microscopy, where it not always easy distinguish macrophages from lymphocytes. We describe here a one-step, easy-to-use, easy-to-customize 8-color flow cytometric method for...
Genome-wide analyses with small cell populations are a major constraint for studies, particularly in the stem field. This work describes an efficient protocol fluorescence-activated sorting (FACS) isolation of satellite cells from limb muscle, tissue high content structural proteins. Dissected muscles adult mice were mechanically disrupted by mincing medium supplemented dispase and type I collagenase. Upon digestion, homogenate was filtered through strainers, suspended FACS buffer. Viability...