A5030770818- Tryptophan and brain disorders
- Neurotransmitter Receptor Influence on Behavior
- Gastrointestinal motility and disorders
- Animal Genetics and Reproduction
- RNA Research and Splicing
- Diet and metabolism studies
- Receptor Mechanisms and Signaling
- Erythrocyte Function and Pathophysiology
- Skin and Cellular Biology Research
- Reproductive Biology and Fertility
- Amyotrophic Lateral Sclerosis Research
- Cardiomyopathy and Myosin Studies
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Asthma and respiratory diseases
- Hemoglobinopathies and Related Disorders
- Mast cells and histamine
- Reproductive Physiology in Livestock
- Neuropeptides and Animal Physiology
- Iron Metabolism and Disorders
- Genomics and Chromatin Dynamics
- T-cell and B-cell Immunology
- Cancer and Skin Lesions
- Hedgehog Signaling Pathway Studies
- Prenatal Substance Exposure Effects
Institut des Maladies Génétiques Imagine
2016-2025
Inserm
2015-2025
Université Paris Cité
2011-2025
Délégation Paris 5
2011-2025
Sorbonne Paris Cité
2012-2025
Centre National de la Recherche Scientifique
2013-2023
Institut Cochin
2021-2022
Laboratory of Excellence GR-Ex
2012-2021
Institut Necker Enfants Malades
2017-2020
McGill University
1993-2020
Serotonin (5-HT) controls a wide range of biological functions. In the brain, its implication as neurotransmitter and in control behavioral traits has been largely documented. At periphery, modulatory role physiological processes, such cardiovascular function, is still poorly understood. The rate-limiting enzyme 5-HT synthesis, tryptophan hydroxylase (TPH), encoded by two genes, well characterized tph1 gene recently identified tph2 gene. this article, based on study mutant mouse which...
The gut contains a large 5-HT pool in enterochromaffin (EC) cells and smaller the enteric nervous system (ENS). During development, neurons are generated asynchronously. We tested hypotheses that serotonergic neurons, which arise early, affect development/survival of later-born dopaminergic, GABAergic, nitrergic, calcitonin gene-related peptide-expressing essential for gastrointestinal motility. biosynthesis depends on tryptophan hydroxylase 1 (TPH1) EC TPH2 neurons; therefore, mice lacking...
The early appearance of serotonin and its receptors during prenatal development, together with the many effects exerts CNS morphogenesis, strongly suggest that influences development maturation mammalian brain before it becomes a neuromodulator/neurotransmitter. Sites biosynthesis, however, have not been detected in mouse embryos or extraembryonic structures, suggesting main source could be maternal origin. This hypothesis was tested by using knockout mice lacking tph1 gene, which is...
Significance Immune complexes (ICs) form when antibodies encounter their antigens. ICs are present in blood multiple pathological conditions. Given the abundance of platelets and that they express a receptor for ICs, called Fcγ IIA (FcγRIIA), we examined impact mouse model. We found circulating induced systemic shock, characterized by loss consciousness, activating platelet FcγRIIA. Shock was mediated liberation serotonin, molecule better known its role brain, from granules. During were...
Mucosal inflammation in the gut is characterized by infiltration of innate and adaptive immune cells an alteration serotonin–producing enterochromaffin cells. We investigated role serotonin function dendritic (DCs) sequential T-cell activation relation to generation inflammation. DCs isolated from tryptophan hydroxylase-1–deficient (TPH1−/−) mice, which have reduced gut, wild-type (TPH1+/+) mice with or without dextran sulfate sodium (DSS)–induced colitis were stimulated lipopolysaccharide...
Peripheral serotonin, synthesized by tryptophan hydroxylase-1 (TPH 1 ), has been shown to play a key role in several physiological functions. Recently, controversy emerged about whether peripheral serotonin any effect on bone density and remodeling.We therefore decided investigate detail remodeling growing mature TPH knockout mice −/− ). Bone resorption mice, as assessed biochemical markers histomorphometry, was markedly decreased at both ages. Using marrow transplantation, we present...
The fragile X syndrome is an X-linked inherited disease and the result of transcriptional inactivation FMR1 gene absence its encoded FMR protein (FMRP). Using a specific monocional antibody directed against human FMRP, we have studied steady-state levels murine homolog in several tissues organs adult young mice. In immunoblot analyses, recognizes heterogeneous subset proteins with apparent molecular weights ranging from 80 to 70 kDa. These are detected all 27 tested; however, relative...
Elevated gut serotonin inhibits autophagy via mTOR promoting a disrupted microbiota and enhanced susceptibility to colitis.
Serotonin (5-HT) has long been recognized as a neurotransmitter in the central nervous system, where it modulates variety of behavioral functions. Availability 5-HT depends on expression enzyme tryptophan hydroxylase (TPH), and recent discovery dual system for synthesis brain (TPH2) periphery (TPH1) renewed interest studying potential functions played by nonnervous tissues. Moreover, characterization TPH1 knockout mouse model (TPH1(-/-)) led to identification unsuspected roles peripheral...
Objective: The lymphatic system is a circulatory that unidirectionally drains the interstitial tissue fluid back to blood circulation. Although lymph utilized by leukocytes for immune surveillance, it remains inaccessible platelets and erythrocytes. Activated cells release submicron extracellular vesicles (EV) transport molecules from donor cell. In rheumatoid arthritis, EV accumulate in joint where they can interact with numerous cellular lineages. However, whether exit inflamed recirculate...