A5011162166- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Maternal Mental Health During Pregnancy and Postpartum
- Neuroendocrine regulation and behavior
- Neonatal Respiratory Health Research
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Gestational Diabetes Research and Management
- Circadian rhythm and melatonin
- Epigenetics and DNA Methylation
- Pregnancy and Medication Impact
- Prenatal Screening and Diagnostics
- COVID-19 and Mental Health
- Heavy Metal Exposure and Toxicity
- Renal and related cancers
- Estrogen and related hormone effects
- Mercury impact and mitigation studies
- Molecular Biology Techniques and Applications
- Healthcare Systems and Practices
- Reproductive Biology and Fertility
- Breastfeeding Practices and Influences
- Neonatal and fetal brain pathology
- Neurotransmitter Receptor Influence on Behavior
- Bone fractures and treatments
- Stress Responses and Cortisol
Institut National de la Recherche Scientifique
2016-2025
Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal
2024-2025
Université du Québec
2019-2025
Université de Montréal
1994-2025
Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean
2024
Centre intégré universitaire de santé et de services sociaux du Nord-de-l’Île-de-Montréal
2024
Research Network (United States)
2023
Université du Québec à Montréal
2006-2022
Armand Frappier Museum
2006-2022
University of Florida
2021
Although the role of melatonin on fetal development has been subject a number studies, little is known about function in placenta. We previously showed that receptors are expressed and functional JEG-3 BeWo cell lines, both vitro models human trophoblast. Local synthesis placenta proposed, but placenta's ability to synthesize de novo never studied. The purpose this study was investigate expression [reverse transcription-polymerase chain reaction (RT-PCR) western blot analysis] activity...
Abstract: The melatonin system in preeclamptic pregnancies has been largely overlooked, especially the placenta. We have previously documented production and expression of its receptors normal human placentas. In addition, we others shown a beneficial role placental fetal functions. line with this, decreased maternal blood levels are found compared normotensive pregnancies. However, pregnancy placentas never examined. This study compares (i) melatonin‐synthesizing enzyme activity, (ii)...
In recent decades there has been an increasing recognition of the need to account for sex and gender in biology medicine, order develop a more comprehensive understanding biological phenomena address gaps medical knowledge that have arisen due generally masculine bias research.We noted as basic experimental biomedical researchers, we face unique challenges incorporation our work, these remained largely unarticulated, misunderstood, unaddressed literature.Here, describe some specific...
Abstract Melatonin is highly produced in the placenta where it protects against molecular damage and cellular dysfunction arising from hypoxia/re‐oxygenation‐induced oxidative stress as observed primary cultures of syncytiotrophoblast. However, little known about melatonin its receptors human throughout pregnancy their role villous trophoblast development. The purpose this study was to determine melatonin‐synthesizing enzymes, arylalkylamine N‐acetyltransferase (AANAT) hydroxyindole...
Melatonin has been proposed as a possible treatment for the deleterious effects of hypoxia/reoxygenation (H/R), such autophagy, inflammation, and apoptosis. Pathological pregnancies, preeclampsia, are associated with placental H/R, decreased melatonin synthesis well lower levels in placenta maternal plasma. However, exogenous on inflammation autophagy induced by pregnancy complications H/R await investigation. This study aimed to determine whether protects human primary villous trophoblasts...
Excessive placental inflammation is associated with several pathological conditions, including stillbirth and fetal growth restriction. Although infection a known cause of inflammation, significant proportion pregnancies have evidence without any detectable infection. Inflammation can also be triggered by endogenous mediators, called damage molecular patterns or alarmins. One these damage-associated patterns, uric acid, increased in the maternal circulation agonist Nlrp3 inflammasome inducer...
Retrospective studies suggest that maternal exposure to a severe stressor during pregnancy increases the fetus' risk for variety of disorders in adulthood. Animal testing fetal programming hypothesis find glucocorticoids pass through placenta and alter brain development, particularly hypothalamic-pituitary-adrenal axis. However, there are no prospective pregnant women exposed sudden-onset independent elucidate biopsychosocial mechanisms responsible wide consequences prenatal stress seen...
Elevated glucose levels at the fetal–maternal interface are associated with placental trophoblast dysfunction and increased incidence of pregnancy complications. Trophoblast cells predominantly utilize as an energy source, metabolizing it through glycolysis in cytoplasm oxidative respiration mitochondria to produce ATP. The TGFβ1/SMAD2 signaling pathway transcription factors PPARγ, HIF1α, AMPK key regulators cell metabolism known play critical roles extravillous differentiation function....
Serum lead, whole blood and lead in both tibia calcaneus were measured each of 49 active workers. correlated more strongly with vivo bone measurements than did lead. The ratio serum to varied from 0.8% 2.5% showed a positive correlation tibia, an even stronger This implies that released (endogenous exposure) results higher proportion being is the case for exogenous exposure. observation needs be confirmed, relationships amongst parameters must studied further, particularly former or retired...