A5088414229- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Preterm Birth and Chorioamnionitis
- COVID-19 Impact on Reproduction
- Pregnancy and Medication Impact
- Birth, Development, and Health
- Neonatal Respiratory Health Research
- Pregnancy-related medical research
- Biomarkers in Disease Mechanisms
- Cardiovascular Issues in Pregnancy
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolomics and Mass Spectrometry Studies
- Neuropeptides and Animal Physiology
- Racial and Ethnic Identity Research
- Neonatal and fetal brain pathology
- Labor market dynamics and wage inequality
- Education and experiences of immigrants and refugees
- HIV-related health complications and treatments
- Adipose Tissue and Metabolism
- COVID-19 and healthcare impacts
- Maternal Mental Health During Pregnancy and Postpartum
- Exercise and Physiological Responses
- Congenital Diaphragmatic Hernia Studies
- HIV/AIDS Research and Interventions
- Molecular Biology Techniques and Applications
Centre Hospitalier Universitaire Sainte-Justine
2016-2024
Institut Agro Rennes-Angers
2023
Physiologie Environnement et Génétique pour l'Animal et les Systèmes d'Elevage
2023
Université de Montréal
2016-2022
Abstract Preterm birth (PTB) is commonly accompanied by in utero fetal inflammation, and existing tocolytic drugs do not target inflammatory injury. Of the candidate proinflammatory mediators, IL-1 appears central sufficient to trigger loss. Therefore, we elucidated effects of antenatal exposure on postnatal development investigated two receptor antagonists, competitive inhibitor anakinra (Kineret) a potent noncompetitive 101.10, for efficacy blocking actions. Antenatal IL-1β induced Tnfa,...
Excessive placental inflammation is associated with several pathological conditions, including stillbirth and fetal growth restriction. Although infection a known cause of inflammation, significant proportion pregnancies have evidence without any detectable infection. Inflammation can also be triggered by endogenous mediators, called damage molecular patterns or alarmins. One these damage-associated patterns, uric acid, increased in the maternal circulation agonist Nlrp3 inflammasome inducer...
Problem Pre‐eclampsia (PE), preterm birth (PTB) and intra‐uterine growth restriction (IUGR) affect 5%‐12% of pregnancies. They have been associated with placental inflammation, although the detection inflammatory mediators in maternal circulation is still controversial. Our goal was to determine changes occurring second part pregnancy identify profiles distinguishing pathological pregnancies from each other. Method Study We performed a nested case‐control study 200 women randomly selected...
Preeclampsia (PE) is a poorly understood pregnancy complication. It has been suggested that changes in the maternal immune system may contribute to PE, but evidence of this remains scarce. Whilst PE commonly experienced prepartum, it can also occur postpartum period (postpartum PE-PPPE), and mechanisms involved are unknown. Our goal was determine whether placenta pregnancies complicated with PPPE, compared normal term pregnancies. We prospectively recruited women collected blood samples...
The reported effects of SARS-CoV-2 on pregnancy outcomes are conflicting; studies frequently overlook the placenta, which is critical for health mother and infant(s). This study aimed to determine effect pandemic stress ± SARS CoV-2 infection placental histopathology.Women were recruited in Canada (n = 69); France 21) or UK 25), between March October 2020. Historic controls (N 20) also included. Placenta fetal membrane samples collected rapidly after delivery fixed stained histopathological...
Abstract Problem The COVID‐19 pandemic has been shown to have a detrimental impact on the mental health of pregnant individuals, and chronic stress can alter immune profile. However, effects system in pregnancy are still poorly understood. We aimed evaluate exposure maternal profile uncomplicated pregnancies. Method study collected blood placenta samples from individuals exposed unexposed compare their inflammatory profiles. performed co‐culture with circulating cells endothelial assess...
Abstract Pre-eclampsia (PE) affects 5–8% of pregnancies and has detrimental effects on maternal–fetal health. PE is characterized by de novo hypertension after 20 wk gestation end-organ damage. Systemic inflammatory imbalance been associated with PE, but its contribution to the pathology poorly understood. Our objective was investigate maternal systemic immune changes in early-onset (EOPE) late-onset (LOPE) versus uncomplicated (control [CTRL]), their endothelial activation, hallmark...
The use of antiretroviral therapy drastically reduces vertical transmission Human Immunodeficiency Virus. However, recent studies demonstrate associations between ART during pregnancy and placental inflammation, particularly within protease inhibitor (PI)-based regimens. We sought to characterize macrophages, namely Hofbauer cells, according the class used pregnancy.Using immunofluorescence immunohistochemistry, placentas from 79 pregnant people living with HIV (PPLWH) 29 HIV-uninfected were...
Pregnancy complications, including preeclampsia (PE), preterm birth (PTB), and intra-uterine growth restriction (IUGR) have individually been associated with inflammation but the combined comparative analysis of their placental profiles at transcriptomic histological levels is lacking. Bulk RNA-sequencing human biopsies from uncomplicated term pregnancies (CTL) complicated early-onset (EO), late-onset (LO) PE, as well PTB IUGR were used to characterize individual molecular profiles. We also...
Uterine labor requires the conversion of a quiescent (propregnancy) uterus into an activated (prolabor) uterus, with increased sensitivity to endogenous uterotonic molecules. This activation is induced by stressors, particularly inflammation in term and preterm labor. Neuromedin U (NmU) neuropeptide known for its uterocontractile effects rodents. The objective study was assess expression function neuromedin receptor 2 (NmU-R2) ligands NmU more potent S (NmS) gestational tissues, possible...
Abstract Prenatal inflammation negatively affects placental function, subsequently altering fetal development. Pathogen-associated molecular patterns (PAMPs) are used to mimics infections in preclinical models but rarely detected during pregnancy. Our group previously developed an animal model of prenatal exposure uric acid (endogenous mediator), leading growth restriction alongside IL-1-driven (Brien et al. J Immunol 198(1):443–451, 2017). Unlike PAMPs, the postnatal impact non-pathogenic...
Introduction Postpartum preeclampsia (PPPE) is an under-diagnosed condition, developing within 48 hours to 6 weeks following uncomplicated pregnancy. The etiology of PPPE still unknown, leaving patients vulnerable and making the identification treatment requiring postpartum care unmet need. We aimed understand immune contribution at time diagnosis, as well uncover predictive potential perinatal biomarkers for early postnatal high-risk patients. Methods Placentas were collected delivery from...