A5066241313- Single-cell and spatial transcriptomics
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immune responses and vaccinations
- Hematopoietic Stem Cell Transplantation
- Immunotherapy and Immune Responses
Institut de génétique et de biologie moléculaire et cellulaire
2021-2023
Inserm
2021-2023
Université de Strasbourg
2021-2023
Centre National de la Recherche Scientifique
2021-2023
The transcriptional regulators that drive regulatory T (Treg) cell development and function remain partially understood. Helios (Ikzf2) Eos (Ikzf4) are closely-related members of the Ikaros family transcription factors. They highly expressed in CD4+ Treg cells functionally important for biology, as mice deficient either or susceptible to autoimmune diseases. However, it remains unknown if these factors exhibit specific redundant functions cells. Here we show with germline deletions both...
Our understanding of cell fate decisions in hematopoietic stem cells is incomplete. Here, we show that the transcription factor Helios highly expressed murine and progenitor (HSPCs), where it required to suppress separation platelet/megakaryocyte lineage from HSPC pool. acts mainly quiescent cells, directly represses megakaryocyte gene expression program as early stage. binding promotes chromatin compaction, notably at regulatory regions platelet-specific genes recognized by Gata2 Runx1...