A5061116683- Arsenic contamination and mitigation
- Cellular Mechanics and Interactions
- Muscle Physiology and Disorders
- CRISPR and Genetic Engineering
- Genomics and Rare Diseases
- Enzyme-mediated dye degradation
- Genetics and Neurodevelopmental Disorders
- Congenital heart defects research
- Pluripotent Stem Cells Research
- Chromium effects and bioremediation
- Genetic Neurodegenerative Diseases
- Microbial Community Ecology and Physiology
- Immune Cell Function and Interaction
- Wnt/β-catenin signaling in development and cancer
- Fungal and yeast genetics research
- Hematopoietic Stem Cell Transplantation
- Mitochondrial Function and Pathology
- Pneumonia and Respiratory Infections
- Single-cell and spatial transcriptomics
- Bacterial Infections and Vaccines
- Genomics and Phylogenetic Studies
- Hippo pathway signaling and YAP/TAZ
- Infective Endocarditis Diagnosis and Management
Institut de génétique et de biologie moléculaire et cellulaire
2013-2023
Université de Strasbourg
2014-2021
Centre National de la Recherche Scientifique
2014-2021
Inserm
2014-2021
Institut de Biologie Moléculaire et Cellulaire
2016
Center for Biologics Evaluation and Research
1988
<h3>Background</h3> Intellectual disability (ID) is characterised by an extreme genetic heterogeneity. Several hundred genes have been associated to monogenic forms of ID, considerably complicating molecular diagnostics. Trio-exome sequencing was recently proposed as a diagnostic approach, yet remains costly for general implementation. <h3>Methods</h3> We report the alternative strategy targeted high-throughput 217 in which mutations had reported patients with ID or autism major clinical...
Abstract Myotonic dystrophy (DM) is caused by the expression of mutant RNAs containing expanded CUG repeats that sequester muscleblind-like (MBNL) proteins, leading to alternative splicing changes. Cardiac alterations, characterized conduction delays and arrhythmia, are second most common cause death in DM. Using RNA sequencing, here we identify novel alterations DM heart samples, including a switch from adult exon 6B towards fetal 6A cardiac sodium channel, SCN5A . We find MBNL1 regulates...
Collagen 6A3 (Col6a3), a component of extracellular matrix, is often up-regulated in tumours and believed to play pro-oncogenic role. However the mechanisms its tumorigenic activity are poorly understood. We show here that Col6a3 highly expressed densely growing mouse embryonic fibroblasts (MEFs). In MEFs where TAF4 subunit general transcription factor IID (TFIID) has been inactivated, elevated expression prevents contact inhibition promoting their 3 dimensional growth as foci fibrospheres....
ABSTRACT We report the genome sequence of Halomonas sp. strain A3H3, a bacterium with high tolerance to arsenite, isolated from multicontaminated sediments l'Estaque harbor in Marseille, France. The is composed 5,489,893-bp chromosome and 157,085-bp plasmid.
Disease and carrier isolates of Neisseria meningitidis were examined for their ability to adhere human buccal epithelial cells cell lines hemagglutinate erythrocytes, properties thought be associated with the presence pili. Seventy percent (7 10) found highly adherent agglutinate A, B, O, Rh-, Rh+ erythrocytes. In contrast, 60% disease adhered poorly 80% failed No adherence either or was observed when several tested. When meningococcal strains by electron microscopy, 7 10 possess large...
Our understanding of cell fate decisions in hematopoietic stem cells is incomplete. Here, we show that the transcription factor Helios highly expressed murine and progenitor (HSPCs), where it required to suppress separation platelet/megakaryocyte lineage from HSPC pool. acts mainly quiescent cells, directly represses megakaryocyte gene expression program as early stage. binding promotes chromatin compaction, notably at regulatory regions platelet-specific genes recognized by Gata2 Runx1...
Genome-wide analyses with small cell populations are a major constraint for studies, particularly in the stem field. This work describes an efficient protocol fluorescence-activated sorting (FACS) isolation of satellite cells from limb muscle, tissue high content structural proteins. Dissected muscles adult mice were mechanically disrupted by mincing medium supplemented dispase and type I collagenase. Upon digestion, homogenate was filtered through strainers, suspended FACS buffer. Viability...