A5049649312- Cellular Mechanics and Interactions
- Cellular transport and secretion
- Cell Adhesion Molecules Research
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Physiological and biochemical adaptations
- Signaling Pathways in Disease
- Fish biology, ecology, and behavior
- Nuclear Structure and Function
- Ichthyology and Marine Biology
Inserm
1993-2020
Université de Strasbourg
2020
Institut de génétique et de biologie moléculaire et cellulaire
2017-2020
Centre National de la Recherche Scientifique
1993-2020
Institut de Biologie Moléculaire et Cellulaire
2002
Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes
1993
Arthritis in the K/BxN mouse model is provoked by pathogenic antibodies (Abs) directed against a ubiquitously expressed protein, glucose-6-phosphate isomerase (GPI). To begin dissecting repertoire of arthritogenic immunoglobulins (Igs) model, and to provide basis for comparison with RA patientswe have generated anti-GPI monoclonal Abs (mAbs) from spontaneously activated B cells lymphoid organs arthritic mice. cell clones specificities were present at extraordinarily high frequencies spleen,...
Skeletal muscle development and regeneration are tightly regulated processes. How the intracellular organization of fibers is achieved during these steps unclear. Here, we focus on cellular physiological roles amphiphysin 2 (BIN1), a membrane remodeling protein mutated in both congenital adult centronuclear myopathies (CNM), that ubiquitously expressed has skeletal muscle-specific isoforms. We created characterized constitutive inducible Bin1 homozygous heterozygous knockout mice targeting...
Abstract Skeletal muscle development and regeneration are tightly regulated processes. How the intracellular organization of fibers is achieved during these steps unclear. Here we focus on cellular physiological roles amphiphysin 2 (BIN1), a membrane remodeling protein mutated in both congenital adult centronuclear myopathies, that ubiquitously expressed has skeletal muscle-specific isoforms. We created characterized constitutive, inducible Bin1 homozygous heterozygous knockout mice...