A5101723012- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Porphyrin and Phthalocyanine Chemistry
- Conducting polymers and applications
- Electrochemical sensors and biosensors
- Cancer, Hypoxia, and Metabolism
- Nanoparticle-Based Drug Delivery
- Immunotherapy and Immune Responses
- Problem and Project Based Learning
- Advanced Sensor and Energy Harvesting Materials
- Polyamine Metabolism and Applications
- Biopolymer Synthesis and Applications
- bioluminescence and chemiluminescence research
- Advanced Computing and Algorithms
- Cellular Mechanics and Interactions
- Graphene and Nanomaterials Applications
- Immune cells in cancer
- Polydiacetylene-based materials and applications
- Electrospun Nanofibers in Biomedical Applications
- Amino Acid Enzymes and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Photoacoustic and Ultrasonic Imaging
- GABA and Rice Research
- Nanofabrication and Lithography Techniques
- Fullerene Chemistry and Applications
National University of Río Cuarto
2010-2020
Consejo Nacional de Investigaciones Científicas y Técnicas
2018-2020
Aim: To assess monocyte-based delivery of conjugated polymer nanoparticles (CPNs) for improved photodynamic therapy (PDT) in glioblastoma (GBM). Materials & methods: Human monocyte cells (THP-1) and murine monocytes isolated from bone marrow (mBMDMs) were employed as stealth CPN carriers to penetrate into GBM spheroids an orthotopic model the tumor. The success PDT, using this cell-mediated targeting strategy, was determined by its effect on spheroids. Results: CPNs did not affect viability...
The photodynamic activities of a porphyrin-C60 dyad (P-C60) and its metal complex with Zn(II) (ZnP-C60) were compared 5-(4-acetamidophenyl)-10,15,20-tris(4-methoxyphenyl)porphyrin (P), both in homogeneous medium-bearing photooxidizable substrates vitro on the Hep-2-human-larynx-carcinoma cell line. This study represents first evaluation dyads, high capacity to form photoinduced charge-separated state, act as agents inactivate cells by therapy (PDT). Absorption fluorescence spectroscopic...
Aim: Assess biocompatibility, uptake and photodynamic therapy (PDT) mechanism of metallated porphyrin doped conjugated polymer nanoparticles (CPNs) in human brain colorectal tumor cells macrophages. Materials & methods: CPNs were developed employing 9,9-dioctylfluorene-alt-benzothiadiazole, an amphiphilic (PS-PEG-COOH), platinum octaethylporphyrin. T98G, SW480 RAW 264.7 cell lines exposed to assess intracellular localization. Additionally, a PDT protocol using was employed for the vitro...
The immune response against cancer generated by type-I-interferons (IFN-1) has recently described. Exogenous and endogenous IFN-/β have an important role in surveillance control of tumor development. In addition, IFN-1s emerged as novel DAMP for the consecutive events connecting innate adaptive immunity they also been postulated essential requirement induction immunogenic cell death (ICD). this context, Photodynamic therapy (PDT) previously linked to ICD. PDT consists administration a...
Abstract In this work, we describe a laser‐assisted microstructuring technique called Direct Laser Interference Patterning to produce topographical cues for tumor cells in one‐step process. Line‐like patterns with spatial periods ranging from 500 nm 10 μm are fabricated on polyimide (PI) films. The resulting structures exhibit well‐defined shape and quality even small periodic distances. Subsequently, the behavior of mouse mammary adenocarcinoma over those is evaluated. results show that...
Photothermal therapy is a in which photon energy converted into heat to kill cancer. The purpose of this study evaluate the vivo efficacy photothermal therapy, toxicity and hepatic renal function polyaniline nanoparticles (PANI-Np) tumor-bearing mice model. nanoparticles, following NIR light exposure, was assessed by examining tumor growth over time compared untreated control. Signs drug histopathology morphology tissues, after intratumoral injection treatment, were examined or monitored....
The study of cellular interactions in the tumor microenvironment has become one main areas research fight against cancer. Tumor-associated macrophages (TAMs) influence progression and therapy response due to its functional plasticity. Regarding cancer treatment, photodynamic (PDT) is a minimally invasive clinically approved procedure that involves administration photosensitizer (PS), nontoxic photosensitizing drug which selectively retained neoplastic tissue. Here, we investigated role...
The photodynamic activities of the free-base 5,10,15,20-tetrakis(4-methoxyphenyl)porphyrin (TMP) and their metal complexes with zinc(II) (ZnTMP), copper(II) (CuTMP) cadmium(II) (CdTMP) have been compared in two systems: reverse micelle n-heptane/sodium bis(2-ethylhexyl)sulfosuccinate/water bearing photooxidizable substrates Hep-2 human larynx carcinoma cell line. quantum yields singlet molecular oxygen, O2(1Δg), production (ΦΔ) TMP, ZnTMP CdTMP tetrahydrofuran, were determined yielding...
Two different approaches are used to produce conducting polymer nano-objects. One is a "top-down" approach which involves laser ablation of films using light interference patterns (direct patterning, DLIP) various surface shapes, including nanowires and nanodots. Polyaniline(PANI) polypyrrole (PPy) nanostructures could be easily produced by films, previously formed in-situ polymerization the aromatic monomers. The other "bottom-up" involving controlled nucleation growth during monomer...
The interaction between live organisms and nanosized materials has become a current focus in toxicology.The aim of this study was to establish the chronic effects PANI-Nps different dispersant on Rhinella arenarum toad larvae.We propose use organism?smodels understand toxic mechanistic modes action that could occur by exposure Nps.AMPHITOX is proving be quick, cheap, facile model conservatively assess toxicity nanomaterials.The both: PANI-Np1 (PANI-Np dispersed PVP) PANI-Np2 PVP+PNIPAM)...
Photodynamic Therapy (PDT) has recently gain attention as alternative treatment of Central Nervous System (CNS) cancer diseases, due to the demonstration successfully elimination gliomas in patients. The implementation PDT for brain tumors, and especially glioblastoma (GBM), already been approved some countries. Due their superb light absorption photostability conjugated polymer nanoparticles (CPNs) are promising photosensitizers (PS) use PDT. Recently, we developed metallated...