A5088065085- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Meat and Animal Product Quality
- Mycotoxins in Agriculture and Food
- Animal Nutrition and Physiology
- Drug Transport and Resistance Mechanisms
- Innovative Microfluidic and Catalytic Techniques Innovation
- Porphyrin and Phthalocyanine Chemistry
- Photopolymerization techniques and applications
- Coccidia and coccidiosis research
- Listeria monocytogenes in Food Safety
- Agricultural safety and regulations
- Immune cells in cancer
- Carcinogens and Genotoxicity Assessment
- Sensory Analysis and Statistical Methods
- Bacterial Identification and Susceptibility Testing
- Iron Metabolism and Disorders
- Antibiotic Resistance in Bacteria
- Neuroinflammation and Neurodegeneration Mechanisms
- Nanoparticle-Based Drug Delivery
- Antibiotics Pharmacokinetics and Efficacy
- Organic Food and Agriculture
National University of Río Cuarto
2019-2025
Consejo Nacional de Investigaciones Científicas y Técnicas
2021-2025
Alternative therapies such as photodynamic therapy (PDT) that combine light, oxygen and photosensitizers (PSs) have been proposed for glioblastoma (GBM) management to overcome conventional treatment issues. An important disadvantage of PDT using a high light irradiance (fluence rate) (cPDT) is the abrupt consumption leads resistance treatment. metronomic regimens (mPDT) involving administering at low irradiation intensity over relatively long period time could be an alternative circumvent...
The present study was conducted to investigate the ability of Saccharomyces cerevisiae RC016 (Sc)-based feed additive reduce liver toxicity, residual aflatoxin B1 (AFB1) levels and influence intestinal structure in broiler chickens fed chronic B1-contaminated diets. A total 100 one-day-old male commercial line (Ross) were divided into 4 treatments, with 5 pens per treatment pen. Birds randomly assigned which namely 1 (T1), control diet (CD); T2, CD + Sc at g/kg; T3, AFB1 μg/kg; T4, g/kg...
Conjugated polymer nanoparticles (CPNs) have emerged as advanced polymeric nanoplatforms in biomedical applications by virtue of extraordinary properties including high fluorescence brightness, large absorption coefficients one and two-photons, excellent photostability colloidal stability water physiological medium. In addition, low cytotoxicity, easy functionalization, the ability to modify CPN photochemical incorporation dopants, convert them into theranostic agents with multifunctionality...
Glioblastoma (GBM) is an aggressive brain cancer characterized by significant molecular and cellular heterogeneity, which complicates treatment efforts. Current standard therapies, including surgical resection, radiation, temozolomide (TMZ) chemotherapy, often fail to achieve long-term remission due tumor recurrence resistance. A pro-oxidant environment involved in glioma progression, with oxidative stress contributing the genetic instability that leads gliomagenesis. Evaluating therapies...
The design of smart photoelectrodes capable stimulating the localized production reactive oxygen species (ROS) on demand is great interest for redox medicine therapies. In this work, poly(3-hexylthiophene) semiconducting polymer nanoparticles (P3HT SPNs) are used with a dual role to fabricate light-responsive hydrogels. First, P3HT SPNs act as visible-light photoinitiators induce photopolymerization acrylic monomers such acrylamide (AAm), 2-(hydroxyethyl) acrylate (HEA), and poly(ethylene...
Glioblastoma (GBM) is an aggressive brain cancer characterized by significant molecular and cellular heterogeneity, complicating treatment efforts. Current standard therapies, including surgical resection, radiation, temozolomide (TMZ) chemotherapy, often fail to achieve long-term remission due tumor recurrence resistance. A pro-oxidant environment in-volved in glioma progression, with oxidative stress contributing the genetic instability that leads gliomagenesis. However, generation of...
The study aims to establish the plasma pharmacokinetic parameters of levofloxacin in mixed-breed dogs, at a single dose 5 mg/kg, intravenously, orally only and with sucralfate pre-treatment (1 g per animal), evaluate its influence on antimicrobial absorption.Concentrations were determined using high-performance liquid chromatography (HPLC) fluorescence detection.After iv levofloxacin, mean (±SD) AUC0–24, Vz, t½λz MRT, was 19.05 ± 6.4 µg-h/ml, 2.43 0.5 L/kg, 7.93 1.41 hours 8.7 1.5 hours,...
The aim was to study the effect of probiotic Saccharomyces cerevisiae RC016 on expression apoptotic protein Bax, Bcl-2, DR4 and c-FLIP, in liver rats exposed aflatoxin B 1 (AFB ). Four treatments were applied inbred male Wistar rats: uncontaminated feed control, S. contaminated with 100 μg/kg AFB + daily oral dose 10 8 viable cells. Histological technique high-resolution light microscopy (HRLM) performed tissue morphology, TUNEL assay used determine apoptosis cellular c-FLIP determinate...