In the last years, extensive attention has been paid on designing and developing functional imaging contrast agents for providing accurate noninvasive evaluation of pathology in vivo. However, issue false-positives or ambiguous lack a robust strategy simultaneous dual-mode remain to be fully addressed. One effective improving it is rationally design magnetic resonance (MRI) (CAs) with intrinsic T1/ T2 features. this work, development characterization one-pot synthesized nanostructured...

Aim: To assess monocyte-based delivery of conjugated polymer nanoparticles (CPNs) for improved photodynamic therapy (PDT) in glioblastoma (GBM). Materials & methods: Human monocyte cells (THP-1) and murine monocytes isolated from bone marrow (mBMDMs) were employed as stealth CPN carriers to penetrate into GBM spheroids an orthotopic model the tumor. The success PDT, using this cell-mediated targeting strategy, was determined by its effect on spheroids. Results: CPNs did not affect viability...

Conjugated polymer nanoparticles (CPNs) have emerged as advanced polymeric nanoplatforms in biomedical applications by virtue of extraordinary properties including high fluorescence brightness, large absorption coefficients one and two-photons, excellent photostability colloidal stability water physiological medium. In addition, low cytotoxicity, easy functionalization, the ability to modify CPN photochemical incorporation dopants, convert them into theranostic agents with multifunctionality...

<title>Abstract</title> Glucose uptake and metabolism are linked to microvascular blood flow cellular swelling events, which altered during obesity can be quantified using magnetic resonance imaging (MRI). Aquaporin-4 (AQP4), the most abundant water-transporting transmembrane protein in central nervous system, facilitates glucose transport metabolism-derived water influx. However, its significance regulatory capacity remain largely unknown. To better understand these processes, we acquired...

Glioblastoma (GBM) causes poor survival in patients even with aggressive treatment. Temozolomide (TMZ) is the standard chemotherapeutic choice for GBM treatment but resistance always ensues. Protein kinase CK2 (CK2) contributes to tumour development and proliferation cancer, it overexpressed human GBM. Accordingly, targeting may benefit patients. Our goal has been evaluate whether inhibitors (iCK2s) could increase an immunocompetent preclinical model. Cultured GL261 cells were treated...

Glioblastoma (GBM) causes poor survival in patients even when applying aggressive treatment. Temozolomide (TMZ) is the standard chemotherapeutic choice for GBM treatment, but resistance always ensues. In previous years, efforts have focused on new therapeutic regimens with conventional drugs to activate immune responses that may enhance tumor regression and prevent regrowth, example “metronomic” approaches. metronomic scheduling studies, cyclophosphamide (CPA) GL261 growing subcutaneously...

The quest for nanomaterial-based imaging probes that can provide positive contrast in MRI is fueled by the necessity of developing novel diagnostic applications with potential clinical translation current gold standard cannot provide. Although interest nanomaterials has increased recent years, their study less developed than traditional negative MRI. In our search new magnetic materials enhanced features as MRI, we decided to explore chemical space comprehensively analyze effects different...

Glioblastoma (GBM) is the most common aggressive primary brain tumor in adults, with a short survival time even after therapy. Non-invasive surrogate biomarkers of therapy response may be relevant for improving patient survival. Previous work produced such preclinical GBM using semi-supervised source extraction and single-slice Magnetic Resonance Spectroscopic Imaging (MRSI). Nevertheless, GBMs are heterogeneous studies could prevent obtaining information. The purpose this was to evaluate...

Abstract Glioblastomas (GB) are brain tumours with poor prognosis even after aggressive therapy. Improvements in both therapeutic and follow‐up strategies urgently needed. In previous work we described an oscillatory pattern of response to Temozolomide (TMZ) using a standard administration protocol, detected through MRSI‐based machine learning approaches. the present work, have introduced Immune‐Enhancing Metronomic Schedule (IMS) every 6‐d TMZ at 60 mg/kg investigated consistence such...

The quest for nanomaterial-based imaging probes that can provide positive contrast in MRI is fueled by the necessity of developing novel diagnostic applications with potential clinical translation current gold standard cannot provide. Although interest nanomaterials has increased recent years, their study less developed than traditional negative MRI. In our search new magnetic materials enhanced features as MRI, we decided to explore chemical space comprehensively analyze effects different...

Glioblastoma (GBM) stands as the most prevalent and lethal malignant brain tumor, characterized by its highly infiltrative nature. This study aimed to identify additional MRI metabolomic biomarkers of GBM impact on healthy tissue using an advanced-stage C6 glioma rat model. Wistar rats underwent a stereotactic injection cells (GBM group, n = 10) or cell medium (sham 4). A multiparametric MRI, including anatomical T

Background: Despite the advances in multimodal therapeutic options, glioblastoma (GBM), most frequent and aggressive of all astrocytomas, remains with a median survival 15 months. It is reported direct correlation between GBM hypoxia higher aggressiveness, poor prognosis greater resistance to different treatments. Because intratumoral interindividual heterogeneity, it not possible predict degree considering physiopathological parameters or conventional neuroimaging studies. In this study, we...

VO(dmpp) 2 ameliorates liver metabolic profile of obese pre-diabetic Zucker rats after 4 weeks treatment, as demonstrated by ex vivo 1 H-HRMAS NMR study.

The quest for nanomaterial-based imaging probes that can provide positive contrast in MRI is fueled by the necessity of developing novel diagnostic applications with potential clinical translation current gold standard cannot provide. Although interest nanomaterials has increased recent years, their study less developed than traditional negative MRI. In our search new magnetic materials enhanced features as MRI, we decided to explore chemical space comprehensively analyze effects different...

The assessment of sexual differences in glioblastoma growth and therapy response has received little attention. We assessed the influence sex MRI features an orthotropic GBM rat model submitted to anti-inflammatory therapy. Multiparametric studies were acquired at early advanced tumor stage development. GBMs untreated males presented a more aggressive pattern &amp;ndash; worsened as progressed than females. While treated revealed positive meloxicam treatment, females did not. Our results...

Preclinical models are needed to study glioblastoma multiforme, the most lethal malignant brain tumor. Human G144-glioblastoma stem cells have been used in vitro studies but there few vivo, especially using MRI approaches. We aimed evaluate for first time our knowledge, a G144 model by multiparametric-MRI. NOD-SCID mice were orthotopically injected with cells, tumor was characterized multiparametric-MRI and dynamic contrast enhancement studies. tumors presented heterogeneous imaging pattern...