A5073362053- Photochemistry and Electron Transfer Studies
- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Porphyrin and Phthalocyanine Chemistry
- Photopolymerization techniques and applications
- Radical Photochemical Reactions
- Molecular spectroscopy and chirality
- Electrochemical Analysis and Applications
- Luminescence and Fluorescent Materials
- Photochromic and Fluorescence Chemistry
- Advanced Polymer Synthesis and Characterization
- Free Radicals and Antioxidants
- Spectroscopy and Quantum Chemical Studies
- TiO2 Photocatalysis and Solar Cells
- Advanced Chemical Physics Studies
- Analytical chemistry methods development
- Analytical Chemistry and Chromatography
- Analytical Chemistry and Sensors
- Silicone and Siloxane Chemistry
- Organic Electronics and Photovoltaics
- Mass Spectrometry Techniques and Applications
- Photoacoustic and Ultrasonic Imaging
- Organic Light-Emitting Diodes Research
- Synthesis and Properties of Aromatic Compounds
- Water Quality Monitoring and Analysis
National University of Río Cuarto
2016-2025
Consejo Nacional de Investigaciones Científicas y Técnicas
2016-2025
Centro Científico Tecnológico - San Juan
2017
Instituto de Investigaciones en Ciencia y Tecnología de Materiales
2017
University of Buenos Aires
2002-2009
University of Göttingen
2009
Fundación Ciencias Exactas y Naturales
2009
Constructor University
2007
Bhabha Atomic Research Centre
2007
Georgetown University
2004-2007
Alternative therapies such as photodynamic therapy (PDT) that combine light, oxygen and photosensitizers (PSs) have been proposed for glioblastoma (GBM) management to overcome conventional treatment issues. An important disadvantage of PDT using a high light irradiance (fluence rate) (cPDT) is the abrupt consumption leads resistance treatment. metronomic regimens (mPDT) involving administering at low irradiation intensity over relatively long period time could be an alternative circumvent...
Aim: To assess monocyte-based delivery of conjugated polymer nanoparticles (CPNs) for improved photodynamic therapy (PDT) in glioblastoma (GBM). Materials & methods: Human monocyte cells (THP-1) and murine monocytes isolated from bone marrow (mBMDMs) were employed as stealth CPN carriers to penetrate into GBM spheroids an orthotopic model the tumor. The success PDT, using this cell-mediated targeting strategy, was determined by its effect on spheroids. Results: CPNs did not affect viability...
Photodynamic therapy (PDT) may be an excellent alternative in the treatment of breast cancer, mainly for most aggressive type with limited targeted therapies such as triple-negative cancer (TNBC). We recently generated conjugated polymer nanoparticles (CPNs) efficient photosensitizers photo-eradication different cells. With aim improving selectivity PDT CPNs, nanoparticle surface conjugation unique 2’-Fluoropyrimidines-RNA-aptamers that act effective recognition elements functional...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSquare-planar complexes of platinum(II) that luminesce in fluid solutionJuan A. Zuleta, Carlos Chesta, and Richard EisenbergCite this: J. Am. Chem. Soc. 1989, 111, 24, 8916–8917Publication Date (Print):November 1, 1989Publication History Published online1 May 2002Published inissue 1 November 1989https://pubs.acs.org/doi/10.1021/ja00206a023https://doi.org/10.1021/ja00206a023research-articleACS PublicationsRequest reuse permissionsArticle...
Conjugated polymer nanoparticles (CPNs) have emerged as advanced polymeric nanoplatforms in biomedical applications by virtue of extraordinary properties including high fluorescence brightness, large absorption coefficients one and two-photons, excellent photostability colloidal stability water physiological medium. In addition, low cytotoxicity, easy functionalization, the ability to modify CPN photochemical incorporation dopants, convert them into theranostic agents with multifunctionality...
The design of smart photoelectrodes capable stimulating the localized production reactive oxygen species (ROS) on demand is great interest for redox medicine therapies. In this work, poly(3-hexylthiophene) semiconducting polymer nanoparticles (P3HT SPNs) are used with a dual role to fabricate light-responsive hydrogels. First, P3HT SPNs act as visible-light photoinitiators induce photopolymerization acrylic monomers such acrylamide (AAm), 2-(hydroxyethyl) acrylate (HEA), and poly(ethylene...
Aim: Assess biocompatibility, uptake and photodynamic therapy (PDT) mechanism of metallated porphyrin doped conjugated polymer nanoparticles (CPNs) in human brain colorectal tumor cells macrophages. Materials & methods: CPNs were developed employing 9,9-dioctylfluorene-alt-benzothiadiazole, an amphiphilic (PS-PEG-COOH), platinum octaethylporphyrin. T98G, SW480 RAW 264.7 cell lines exposed to assess intracellular localization. Additionally, a PDT protocol using was employed for the vitro...
Photodynamic inactivation (PDI) protocols using photoactive metallated porphyrin-doped conjugated polymer nanoparticles (CPNs) and blue light were developed to eliminate multidrug-resistant pathogens. CPNs-PDI varying particle concentrations irradiation doses tested against nine pathogenic bacterial strains including antibiotic-resistant bacteria of the ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter...
The solvatochromism and thermochromism of 4-aminophthalimide 4-amino-N-methylphthalimide were studied by absorption steady state time-resolved fluorescence emission in solvent mixtures toluene−ethanol toluene−acetonitrile the temperature range 5−70 °C. wavelengths maximum shift to red with increase proportion polar component mixture. greater affinity for mixture excited compared ground enhances preferential solvation, which is origin this shift. On other hand, a spectral blue found upon...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotocyclization of .alpha.-keto amides in homogeneous solution and aqueous cyclodextrin media. The role zwitterions diradicals photoinduced electron transfer reactionsCarlos A. Chesta David G. WhittenCite this: J. Am. Chem. Soc. 1992, 114, 6, 2188–2197Publication Date (Print):March 1, 1992Publication History Published online1 May 2002Published inissue 1 March...
We report on the photosensitization of titanium dioxide nanoparticles (TiO2 NPs) synthesized inside AOT (bis(2-ethylhexyl) sulfosuccinate sodium salt) reverse micelles following photoexcitation perylene derivatives with dicarboxylate anchoring groups. The dyes, 1,7-dibromoperylene-3,4,9,10-tetracarboxy dianhydride (1), 1,7-dipyrrolidinylperylene-3,4,9,10-tetracarboxy (2), and 1,7-bis(4-tert-butylphenyloxy)perylene-3,4,9,10-tetracarboxy (3), have considerably different driving forces for...
Conjugated polymers (CPs) are known to generate radical reactive oxygen species (ROS) such as hydrogen peroxide through photoinduced charge transfer processes involving water. In this work, ability radicals is utilized here use conducting polymer nanoparticles (CPNs) photoinitiator systems (PIS) for the polymerization of acrylic monomers in aqueous media. The CPNs do not require co-initiators and also act cross-linkers. with different light-absorption properties effectively initiate...
Steady-state and time-resolved emission spectroscopy (TRES) of the medium-sensitive probes 4-aminophthalimide (4-AP) 6-propionyl-2-(dimethylamino)naphthalene (Prodan) were performed at 77 298 K in vacuum-sealed thin films poly(vinyl alcohol) (PVA) acetate) (PVAc). The two show similar red-edge effect steady state a red shift with time TRES PVA. In PVAc shifts are much smaller spectral for 4-AP is slower. locates highly polar environments PVA, where H-bond interaction polymer important....
Steady-state and laser-pulsed irradiations of dibenzyl ketone (ACOB0) derivatives with a p-methyl or p-hexadecyl chain (ACOB1 ACOB16, respectively) have been conducted in polyethylene films 0, 46, 68% crystallinities. Calculation the fractions in-cage combinations triplet benzylic radical-pair intermediates based on photoproduct yields, Fc, from ACOB16 are shown to be incorrect as result kinetic consequences drastically different diffusion coefficients for benzyl p-hexadecylbenzyl radicals....