A5056876857- Bone Tumor Diagnosis and Treatments
- Genetic factors in colorectal cancer
- Musculoskeletal synovial abnormalities and treatments
- Oral and Maxillofacial Pathology
- Natural product bioactivities and synthesis
- Colorectal Cancer Screening and Detection
- Plant Toxicity and Pharmacological Properties
- Orthopedic Surgery and Rehabilitation
- Bioactive Compounds and Antitumor Agents
- Phytochemical compounds biological activities
- Bone health and treatments
- Medical Imaging and Pathology Studies
- Pharmacological Effects of Natural Compounds
- Drug Transport and Resistance Mechanisms
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Biological Research and Disease Studies
- Pancreatic and Hepatic Oncology Research
- Teratomas and Epidermoid Cysts
- Otitis Media and Relapsing Polychondritis
- Catalytic Alkyne Reactions
- Berberine and alkaloids research
- Multicomponent Synthesis of Heterocycles
- Microbial infections and disease research
- Vascular Anomalies and Treatments
Universidad Católica de Córdoba
2011-2022
Consejo Nacional de Investigaciones Científicas y Técnicas
2018-2022
University of Puerto Rico System
2021
Hospital Italiano de Buenos Aires
2016-2019
Cleveland Clinic Florida
2019
Instituto Universitario Hospital Italiano
2018
Hospital Universitario de Valme
1995
The antibacterial and cytotoxic effects of metabolites isolated from an extract Flourensia oolepis were evaluated. Bioguided fractionation led to five flavonoids, identified as 2′,4′-dihydroxychalcone ( 1 ), isoliquiritigenin 2 pinocembrin 3 7-hydroxyflavanone 4 7,4′-dihydroxy-3′-methoxyflavanone 5 ). Compound showed the highest effect, with minimum inhibitory concentration (MIC) values ranging 31 62 250 μ g/mL, against Gram-positive Gram-negative bacteria, respectively. On further assays,...
P-glycoprotein (P-gp) is a membrane protein associated with multidrug resistance (MDR) due to its key role in mediating the traffic of chemotherapeutic drugs outside cancer cells, leading cellular response that hinders efforts toward successful therapy. With aim finding agents circumvent MDR phenotype mediated by P-gp, 15 compounds isolated from native and naturalized plants Argentina were screened. Among these, non-cytotoxic lignan (±) pinoresinol successfully restored sensitivity...
Plants are a significant reservoir of cytotoxic agents, including compounds with the ability to interfere multidrug-resistant (MDR) cells. With aim finding promising candidates for chemotherapy, 91 native and naturalized plants collected from central region Argentina were screened their effect toward sensitive MDR P-glycoprotein (P-gp) overexpressing human leukemia cells by means MTT assays. The ethanol extracts obtained Aldama tucumanensis , Ambrosia elatior Baccharis artemisioides...
The present study investigated the antibacterial activity of two plant-derived compounds, 23-methyl-6-O-desmethylauricepyrone (1) and (Z,Z)-5-(trideca-4,7-dienyl)resorcinol (2), their synergistic effects with erythromycin gentamicin against methicillin-susceptible (MSSA) gentamicin- methicillin-resistant Staphylococcus aureus (MRSA). Studies individual each compound synergy experiments were carried out, by microdilution test in agar checkerboard method, respectively. Compound 1 showed...
To find novel P-gp-inhibitors, a library of pregnane X receptor (PXR) ligands and the ZINC DrugsNow were superimposed on P-gp inhibitor (+)-pinoresinol (1) used as query for three-dimensional similarity search. After determining TanimotoCombo index with 1, eight compounds from PXR two selected biological evaluation. The inhibition study showed that 7, 8, 9 successfully increased intracellular doxorubicin (DOX) accumulation in overexpressed Lucena 1 cells 25, 12.5, 6.25 μM, respectively....
Inactivating mutations in the MLH1 gene cause cancer predisposition Lynch syndrome, but for small coding genetic variants it is mostly unclear if they are inactivating or not. Nine such have been identified South American colorectal (CRC) patients (p.Tyr97Asp, p.His112Gln, p.Pro141Ala, p.Arg265Pro, p.Asn338Ser, p.Ile501del, p.Arg575Lys, p.Lys618del, p.Leu676Pro), and evidence of pathogenicity neutrality was not available majority these variants. We therefore performed biochemical laboratory...
<i>Objective:</i> Percutaneous needle biopsy is an effective and safe technique for obtaining diagnostic material from bone lesions. <i>Study Design:</i> We describe the technical details of fine aspiration core performed in our laboratory orthopedic pathology. <i>Results:</i> With these procedures, we obtained accurate diagnosis 83% 7,375 cases, sent by different centers country, over a period 21 years (1986–2007). <i>Conclusion:</i>...
Several plants from South America show strong antitumoral properties based on anti-proliferative and/or pro-apoptotic activities. In this work we aimed to identify selective cytotoxic compounds that target BRCA1-deficient cancer cells by Synthetic Lethality (SL) induction. Using a high-throughput screening technology developed in our laboratory, analyzed collection of extracts 46 native plant species Argentina using wide dose-response scheme. A highly SL-induction capacity was found an...
Background: Tumor angiogenesis is considered as a crucial pathologic feature of cancer with key role in multidrug resistance (MDR). Adverse effects the currently available drugs and development to these remain hardest obstacles defeat. Objetive: This work explores flora from Argentina source new chemical entities antiangiogenic activity. Methods: Tube formation assay using bovine aortic endothelial cells (BAECs) was experiment choice assess The effect pure compound cell invasiveness...
Amyloidosis is a heterogeneous disease with wide array of clinical presentations caused by abnormal deposition protein aggregates in different tissues. Broadly, it presents systemic or organ-specific involvement. Laryngeal amyloidosis rare type localized usually presenting dysphonia. It most commonly involves the glottis and frequently follows persisting recurring pattern despite treatment. carcinoma situ premalignant condition vocal cords that may manifest similar voice complaints. Excision...