To assess the presence of self-reactive immune responses to seminal and prostate antigens (PAg), biomarkers inflammation male genital tract, semen quality parameters in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).Peripheral blood samples were collected from CP/CPPS age-matched healthy control volunteers. We analysed lymphoproliferative peripheral mononuclear cells (PBMC) different plasma (SP)-derived purified PAg, serum autoantibodies specific leucocyte...

Abstract Ureaplasma urealyticum and Mycoplasma hominis are among the most prevalent sexually transmitted infections proposed to induce urogenital inflammation impair sperm quality. However, topic remains controversial since contradictory findings have been reported. Herein, we performed a comprehensive analysis of U. M. their association with (i.e., leukocyte subsets inflammatory cytokines in semen,) quality parameters cohort men couple’s primary infertility undergoing initial evaluation or...

Introduction: COVID-19 exerts deleterious effects on the respiratory, cardiovascular, gastrointestinal, and central nervous systems, causing more severe disease in men than women. However, cumulative reported data about putative consequences male reproductive tract fertility are controversial. Furthermore, long-term of SARS-CoV-2 infection still uncertain. Methods: In this study, we prospectively evaluated levels inflammatory cytokines leukocytes semen sperm quality parameters a cohort 231...

Introduction Human papillomavirus (HPV) is the most common sexually transmitted viral infection worldwide, which has been suggested to induce male urogenital inflammation and affect fertility. However, reported evidence scarce inconclusive. Moreover, putative effects of coinfections remain largely unexplored. This study aimed analyze HPV infection, both as a single in conjunction with other uropathogens, along its impact on inflammatory biomarkers semen, oxidative stress sperm quality....

BACKGROUND: The relationship between chronic prostatitis and fertility has been controversial for many years. We have previously shown the presence of a cellular autoimmune response against prostate antigens in group patients. Our main goal was to investigate whether (either caused by an infection or gland) could deleterious effect on semen quality. METHODS: Forty-four patients diagnosed as suffering from were included divided into groups according and/or antigens. Healthy normal individuals...

Antisperm antibodies (ASA) are associated with male subfertility. However, results on sperm surface autoantibodies controversial, the relationship between ASA and semen parameters (WHO, 2010) is unknown, data kinematics scarce.A retrospective study carried out in men undergoing routine analysis (WHO 2010), evaluation (direct SpermMAR(™) (IgG) test), computer-assisted (CASA).A 2.6% a 5.9% incidence of ASA-positive cases were found (cut-off 50% 10%, respectively; n = 7492). samples had lower...

Abstract Female and male infertility have been associated to Chlamydia trachomatis , Ureaplasma spp. Mycoplasma hominis urogenital infections. However, evidence from large studies assessing their prevalence putative associations in patients with is still scarce. The study design was a cross-sectional including 5464 recent diagnosis of couple’s primary 404 healthy control individuals Cordoba, Argentina. Overall, the C. M. infection significantly higher than (5.3%, 22.8% 7.4% vs. 2.0%, 17.8%...

The aim of the present study was to investigate still contentious association between body mass index (BMI) and seminal quality. To this end, 4860 male patients (aged 18–65 years; non-smokers non-drinkers), were classified according BMI as either underweight (UW; <20 kg m–2; n = 45), normal weight (NW; 20–24.9 1330), overweight (OW; 25–29.9 2493), obese (OB; 30–39.9 926) or morbidly (MOB; ≥40 57). Conventional semen parameters concentrations fructose, citric acid neutral α-glucosidase...

beta-Microseminoprotein (MSMB) is one of the most abundant proteins in human seminal plasma. The objectives this study were: (1) to purify MSMB from plasma (SP) and generate antibodies against pure protein; (2) investigate interaction with ejaculated spermatozoa its possible effect on spontaneous acrosome reaction (AR); (3) quantify content SP examine relationship clinical sperm parameters. was purified presence surface examined by indirect immunofluorescence using a specific polyclonal...

Chlamydia trachomatis is the most prevalent sexually transmitted bacterial infection. However, whether has a negative impact on sperm quality and male fertility still controversial. Herein, we report effects of in vitro exposure spermatozoa to trachomatis, also genital infection using an animal model. Human mouse were obtained from healthy donors cauda epididimys C57BL/6 mice, respectively. Highly motile human or exposed C. (serovar E LGV) muridarum, Then, parameters analyzed. Moreover,...

Human Papillomavirus (HPV), a prevalent sexually transmitted infection, comprises high-risk (HR-HPV) and low-risk (LR-HPV) viruses, the former posing high risk for developing malignancies whereas latter mainly benign warts. Despite increasing awareness of HPV’s impact on men’s health, influence HR-HPV LR-HPV urogenital infections male fertility potential remains uncertain. This study aimed to investigate whether infection with HR- or associates impaired sperm quality, oxidative stress,...

alcohol, tabaco, pesticidas, drogas, etc es bien conocida (8-13), sólo en unos pocos estudios se controlan estadísticamente estos factores con el fin de evitar la malinterpretación los resultados.

Abstract The prevalence of HPV infection and its relationship with other sexually transmitted infections was analyzed in a cohort 117 male partners infertile couples from Cordoba, Argentina. Semen samples urethral swabs were obtained the HPV, Chlamydia trachomatis , HSV1, HSV2, Mycoplasma hominis Ureaplasma urealyticum analyzed. A 27.4% found. Interestingly, by exclusively low risk genotypes or high/intermediate present 64.5% 22.6% cases, respectively. Low risk-HPV6 most frequently detected...

Most studies evaluating the possible seasonal variation of semen quality have considered temperature as only causal factor.To assess seasonality in sperm and associations between parameters several meteorological variables (temperature, humidity, apparent atmospheric pressure) a large cohort andrological patients.This was retrospective, cross-sectional correlational/descriptive study.Patients (n: 15665) were categorised into four groups (summer, winter, spring autumn) according to date...

The aim of this study was to recategorise body mass index (BMI) in order classify patients according their risk semen abnormalities. Patients (n=20563) presenting at an andrology laboratory were classified into five groups BMI: underweight (BMI <20kg m−2), normal weight 20–24.9kg overweight 25–29.9kg obese 30–39.9kg m−2) and morbidly >40kg m−2). Semen quality evaluated determine: (1) differences between using analysis variance (ANOVA); (2) the chances abnormalities (using...

Since obesity and male subfertility have increased in parallel during the last decades, hypothesis of an association between these two phenomena has been explored by several researchers. Although there is no consensus apparently impacts men's reproductive potential mechanisms, like alterations on hypothalamus-pituitary-testicular axis, modifications spermatogenesis semen quality and/or impairment sexual health. This review intends to summarize underlying bases such propose new ones, without...