A5103040651- Regulation of Appetite and Obesity
- Ovarian function and disorders
- Hypothalamic control of reproductive hormones
- Adipose Tissue and Metabolism
- Sperm and Testicular Function
- Biochemical effects in animals
- Birth, Development, and Health
- Apelin-related biomedical research
- Hormonal and reproductive studies
- melanin and skin pigmentation
- Male Reproductive Health Studies
- Reproductive Biology and Fertility
- Diet, Metabolism, and Disease
- Reproductive System and Pregnancy
- Sexual Differentiation and Disorders
- Selenium in Biological Systems
- Biochemical Analysis and Sensing Techniques
Universidad Nacional de Córdoba
2010-2023
Instituto de Investigaciones en Ciencias de la Salud
2015-2023
Consejo Nacional de Investigaciones Científicas y Técnicas
2015-2023
Centro Científico Tecnológico - Córdoba
2021
The aim of the present study was to investigate still contentious association between body mass index (BMI) and seminal quality. To this end, 4860 male patients (aged 18–65 years; non-smokers non-drinkers), were classified according BMI as either underweight (UW; <20 kg m–2; n = 45), normal weight (NW; 20–24.9 1330), overweight (OW; 25–29.9 2493), obese (OB; 30–39.9 926) or morbidly (MOB; ≥40 57). Conventional semen parameters concentrations fructose, citric acid neutral α-glucosidase...
In order to clarify the physiological role of ghrelin in gestation, we evaluated effects administration exogenous (2 or 4 nmol/animal per day) its antagonist (6 day (d-Lys3)GHRP6) on fertilization, early embryo development, and implantation periods mice. Three experiments were performed, treating female mice with antagonist: i) starting from 1 week before copulation 12 h after copulation, killed at 18 gestation; ii) since ovulation induction until 80 later, when retrieved embryos...
Ghrelin (Ghr) is a gut/hypothalamus peptide with inhibitory actions on reproductive physiology; however, there are no previous reports of its role estrous behavior. Under the hypothesis that increase plasma Ghr during food restriction (FR) responsible for receptivity reduction, we intended to evaluate percentage female mice subjected to: exp. 1) acute and chronic FR administration (3 nmol/animal/day, s. c.) 2) co-administration ghrelin antagonist [ant=(d-Lys3)-GHRP-6; 6 nmol/animal/day c.]....
Ghrelin (Ghr) has been associated with reproductive physiology and pre- postnatal development. The objectives of the present study were to evaluate effects hexarelin (HEX; 100 or 200 µg kg−1 day−1), a therapeutic Ghr analogue, on: (1) embryo development 60 h post ovulation, induced pharmacologically, in pregnant mice; (2) physical, neurobiological sexual offspring female mice injected HEX during first, second third week pregnancy throughout entire pregnancy; (3) adult memory acquisition...
The purpose of this study was to evaluate the intragestational role ghrelin in offspring development and reproductive programming a mouse model imbalance during pregnancy. Female mice were injected with (supraphysiological levels: 4 nmol/animal/day), antagonist (endogenous inhibition (D-Lys3)GHRP-6, 6 nmol/animal/day) or vehicle (control = normal levels) throughout Parameters evaluated litters growth, physical, neurobiological sexual and, at adulthood, function. Litter size initial weight...
Hexarelin (HEXr), a synthetic ghrelin analogue, has been associated with modifications of reproductive physiology. In previous studies adult mice, we detected that HEXr induced significantly reduced ovulation rate and significant correlation coefficients between sexual maturation corporal weight in offspring. this study, investigated the effects chronic administration on sperm concentration functional activity, oestrous cyclicity pregnancy index, addition to number fetuses its corpora lutea....
It has been demonstrated that food intake and reproductive physiology are both simultaneously modulated to optimize success under fluctuating metabolic conditions. Ghrelin (GHRL) is an orexigenic peptide identified as the endogenous ligand of growth hormone secretagogue receptor being investigated for its potential role on reproduction. Considering data available so far still limited characterization GHRL action mechanism system not fully elucidated, we studied participation hypothalamus in...
The aim of this study was to recategorise body mass index (BMI) in order classify patients according their risk semen abnormalities. Patients (n=20563) presenting at an andrology laboratory were classified into five groups BMI: underweight (BMI &lt;20kg m−2), normal weight 20–24.9kg overweight 25–29.9kg obese 30–39.9kg m−2) and morbidly &gt;40kg m−2). Semen quality evaluated determine: (1) differences between using analysis variance (ANOVA); (2) the chances abnormalities (using...
The objectives of this study were: 1) to evaluate the effects a fructose enriched diet (FED) on rat sperm quality, epididymal function (i.e. oxidative stress and alpha-glucosidase expression) testosterone concentrations; 2) determine if administration ghrelin (Ghrl), reverses induced by FED. After validating protocol as an inductor metabolic syndrome like-symptoms, adult male rats were assigned one following treatments for 8 weeks: FED = 10% in water (v/v); + Ghrl plus (6 nmol/animal/day,...
Introduction In a previous study we found that ghrelin (Ghrl) misbalance during the peri-implantation period significantly impaired fetus development. this aimed to evaluate putative mechanisms underlying these effects, including embryo implantation success, uterine nitric oxide synthase (NOS) activity, synthesis and inflammatory/immune profile. Methods Ghrelin was induced by injecting 4nmol/animal/day of Ghrl (hyperghrelinemia) or 6nmol/animal/day antagonist (Ant: (D-Lys3)GHRP-6) from day 3...
Ghrelin signals to the hypothalamus inhibit reproduction during times of food scarcity. In this study, we demonstrate that ghrelin impairs sperm quality in male mice.Ghrelin (GHRL) is an orexigenic peptide has been investigated as one responsible for reproductive performance mammals under fluctuating metabolic conditions. Central GHRL administration spermatogenesis mice by regulating hypothalamic-pituitary-gonadal axis function. present role a mediator effects on fertilizing capacity and...
We have demonstrated that ghrelin (Ghrl) participates in fetal programming, since intragestational hyperghrelinaemia increased pup's growth and a Ghrl-receptor antagonist accelerated offspring's sexual maturation impaired their adult reproductive function. Now, we aim to analyse if these phenotypic changes (found F1) also occurred F2 and/or F3 generations.We treated mice dams (F0), with 4nmol/animal/day of Ghrl or 6nmol/animal/day an [Ant:(d -Lys3)GHRP6] from day 1 pregnancy until delivery....