A5014359280- Down syndrome and intellectual disability research
- Immunodeficiency and Autoimmune Disorders
- Amphibian and Reptile Biology
- Animal Behavior and Reproduction
- Tryptophan and brain disorders
- Primate Behavior and Ecology
- Epigenetics and DNA Methylation
- Single-cell and spatial transcriptomics
- Inflammasome and immune disorders
- Immune cells in cancer
- Team Dynamics and Performance
- COVID-19 Clinical Research Studies
- Adolescent and Pediatric Healthcare
- Immune Cell Function and Interaction
- Family Support in Illness
- Evolutionary Psychology and Human Behavior
- Genetics and Neurodevelopmental Disorders
- T-cell and B-cell Immunology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Animal Vocal Communication and Behavior
- Management and Organizational Studies
- Neuroendocrine regulation and behavior
- Plant and animal studies
- Autism Spectrum Disorder Research
- Complex Systems and Decision Making
University of Colorado Anschutz Medical Campus
2018-2023
The Medical Center of Aurora
2022
University of Denver
2015-2019
Eastern Michigan University
1974
Abstract Down syndrome (DS), the genetic condition caused by trisomy 21, is characterized variable cognitive impairment, immune dysregulation, dysmorphogenesis and increased prevalence of diverse co-occurring conditions. The mechanisms which 21 causes these effects remain largely unknown. We demonstrate that triplication interferon receptor ( IFNR ) gene cluster on chromosome necessary for multiple phenotypes in a mouse model DS. Whole-blood transcriptome analysis demonstrated overexpression...
Trisomy 21 (T21) causes Down syndrome (DS), a condition characterized by high prevalence of autoimmune disorders. However, the molecular and cellular mechanisms driving this phenotype remain unclear. Building upon our previous finding that T cells from people with DS show increased expression interferon (IFN)-stimulated genes, we have completed comprehensive characterization peripheral cell compartment in adults without conditions. CD8+ are depleted naïve subsets enriched for differentiated...
People with Down syndrome (DS; trisomy 21) display a different disease spectrum relative to the general population, including lower rates of solid malignancies and higher incidence neurological autoimmune conditions. However, mechanisms driving this unique clinical profile await elucidation. We completed deep mapping immune system in adults DS using mass cytometry evaluate 100 cell types, which revealed global dysregulation consistent chronic inflammation, key changes myeloid lymphoid...
Trisomy 21 (T21) causes Down syndrome (DS), affecting immune and neurological function by ill-defined mechanisms. Here we report a large metabolomics study of plasma cerebrospinal fluid, showing in independent cohorts that people with DS produce elevated levels kynurenine quinolinic acid, two tryptophan catabolites potent immunosuppressive neurotoxic properties, respectively. Immune cells overexpress IDO1, the rate-limiting enzyme pathway (KP) known interferon (IFN)-stimulated gene....
Individuals with Down syndrome (DS; trisomy 21) display hyperactivation of interferon (IFN) signaling and chronic inflammation, which could potentially be explained by the extra copy four IFN receptor (IFNR) genes encoded on chromosome 21. However, clinical effects hyperactivity in DS remain undefined. Here, we report that a commonly used mouse model overexpresses IFNR shows hypersensitivity to ligands diverse immune cell types. When treated repeatedly TLR3 agonist induce these animals...
The evolutionary loss of sexual signals is taxonomically widespread and quite common. These are often important not only in mate choice but also male competition for territories females; yet, has rarely been investigated the context signal loss. We asked whether red throat color three-spine stickleback (Gasterosteus aculeatus), an ancestral both choice, accompanied by changes to intrasexual selection. Several freshwater populations have lost throat, instead develop black breeding coloration....
Male cognition has gained recognition as an important potential player in sexual selection. A number of studies have found positive correlations between male signals and cognitive performance and/or female preferences for males with better performance, although other not these relationships. Sex roles can differ dramatically, sex differences selection on likely follow from the different tasks associated roles. Here, using threespine stickleback Gasterosteus aculeatus, a species clearly...
Abstract Trisomy 21 causes Down syndrome, a condition characterized by cognitive impairments, immune dysregulation, and atypical morphogenesis. Using whole blood transcriptome analysis, we demonstrate that specific overexpression of four interferon receptors encoded on chromosome associates with chronic hyperactivity systemic inflammation in syndrome. To define the contribution receptor to syndrome phenotypes, used genome editing correct gene dosage mice carrying triplication large genomic...
Abstract Cognitive ability varies dramatically among individuals, yet the manner in which this variation correlates with reproduction has rarely been investigated. Here, we ask (1) do male sexual signals reflect their cognitive ability, and (2) is associated mating success? Specifically, presented threespine sticklebacks ( Gasterosteus aculeatus ) a detour‐reaching task to assess initial inhibitory control. Fish that performed better were those who solved task, it faster, required fewer...
Abstract Cytokine storms are drivers of pathology and mortality in myriad viral infections affecting the human population. In SARS-CoV-2-infected patients, strength cytokine storm has been associated with increased risk acute respiratory distress syndrome, myocardial damage, death. However, therapeutic value attenuating COVID-19 remains to be defined. Here, we report results obtained using a novel mouse model lethal sterile anti-viral immune responses. Using Down syndrome (DS) segmental...
Individuals can reduce sampling costs and increase foraging efficiency by using information provided others. One simple form of social use is delayed local enhancement or increased interest in a location because the past presence We tested for two ecomorphs stickleback fish, benthic limnetic, from three different lakes with putative independent evolutionary origins. Two these have reproductively isolated (species-pairs), whereas third, previously intact species-pair recently collapsed into...
Abstract People with Down syndrome (DS), the genetic condition caused by trisomy of chromosome 21 (chr21), have an altered disease spectrum. For example, adults DS are largely protected from solid tumors while predisposed to various autoimmune disorders, early-onset Alzheimer’s disease, and severe respiratory infection. While immune system is known play a key role in these comorbidities among disomic population, there dearth studies DS. Here, we applied single-cell, systems-level approach...
ABSTRACT Trisomy 21 (T21) causes Down syndrome (DS), affecting immune and neurological function by unknown mechanisms. We report here the results of a large metabolomics study showing that people with DS produce elevated levels kynurenine quinolinic acid, two tryptophan catabolites potent immunosuppressive neurotoxic properties, respectively. found cells overexpress IDO1, rate-limiting enzyme in pathway (KP) known interferon (IFN)-stimulated gene. Furthermore, we positive correlation between...
Down syndrome (DS), trisomy of human chromosome 21 (Hsa21), is the most common genetic cause intellectual disability. The Dp10(1)Yey (Dp10) a mouse model DS that trisomic for orthologs 25% Hsa21 protein-coding genes, entirety syntenic region on 10. Trisomic genes include several involved in brain development and function, two modify regulate activities sex hormones, produce sex-specific phenotypes as null mutants. These last four are only with known sexually dimorphic properties. Relatively...
Management assumptions about leadership styles and the use of human resources greatly influence participative decision-making problem- solving climate within organization. This article explores some major (PDM) theories corollary research regarding interpersonal dynamics organizational communication in superior-subordinate relationships.
Abstract Down syndrome (DS) is caused by triplication of chromosome 21 (chr21) and the most common chromosomal abnormality (1/700 live births). Our lab recently identified interferons (IFNs) as a core signaling pathway hyperactivated among diverse lineages primary immune cells from individuals with DS. Notably, four six IFN receptor (IFNR) subunits for Types I, II, III IFNs are encoded on chr21. Heightened in disomic population associated developmental defects, cognitive impairments,...