A5067193925- Immunodeficiency and Autoimmune Disorders
- Down syndrome and intellectual disability research
- Diabetes and associated disorders
- Galectins and Cancer Biology
- Neuroinflammation and Neurodegeneration Mechanisms
- T-cell and B-cell Immunology
- Autoimmune Bullous Skin Diseases
- Coastal wetland ecosystem dynamics
- RNA modifications and cancer
- Legume Nitrogen Fixing Symbiosis
- Plant responses to water stress
- Alzheimer's disease research and treatments
- Constructed Wetlands for Wastewater Treatment
- Peatlands and Wetlands Ecology
- S100 Proteins and Annexins
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
University of Colorado Anschutz Medical Campus
2022-2025
University of California, Santa Barbara
2025
Pediatrics and Genetics
2024
Colorado State University
2024
University of Kansas Medical Center
2024
Loyola Marymount University
2023
The Medical Center of Aurora
2022
Abstract Down syndrome (DS), the genetic condition caused by trisomy 21, is characterized variable cognitive impairment, immune dysregulation, dysmorphogenesis and increased prevalence of diverse co-occurring conditions. The mechanisms which 21 causes these effects remain largely unknown. We demonstrate that triplication interferon receptor ( IFNR ) gene cluster on chromosome necessary for multiple phenotypes in a mouse model DS. Whole-blood transcriptome analysis demonstrated overexpression...
Abstract Individuals with Down syndrome, the genetic condition caused by trisomy 21, exhibit strong inter-individual variability in terms of developmental phenotypes and diagnosis co-occurring conditions. The mechanisms underlying this variable clinical presentation await elucidation. We report an investigation human chromosome 21 gene overexpression hundreds research participants which led to identification two major subsets co-expressed genes. Using clustering analyses, we identified three...
This study sought to evaluate proteomic, metabolomic, and immune signatures in the cerebrospinal fluid of individuals with Down Syndrome Regression Disorder (DSRD). A prospective case-control comparing profiles DSRD was performed. Samples were obtained from a biorepository affected compared clinically available data previously neurodiagnostic studies. Individuals established neuroinflammatory conditions (e.g., multiple sclerosis), neurotypical controls undergoing lumbar puncture for...
Background Seagrass meadows are ecologically significant habitats that globally threatened. Thus, there is increased interest in conservation of seagrasses as they face widespread decline. Biotic and abiotic factors influence seagrass can be classified stressors, such rising temperature eutrophication. Our study met an imminent need to consolidate data from previous studies discern knowledge gaps identify trends studies, species, geographic origination research for the genus Zostera . For...
Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), is characterized delayed neurodevelopment, accelerated aging, and increased risk of many co-occurring conditions. Hypoxemia dysregulated hematopoiesis have been documented in DS, but underlying mechanisms clinical consequences remain ill defined. We report an integrative multi-omic analysis ∼400 research participants showing that people with DS display transcriptomic signatures indicative elevated heme metabolism hypoxic...
Background: Individuals with Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), display clear signs of immune dysregulation, including high rates autoimmunity and severe complications from infections. Although it is well established that T21 causes increased interferon responses JAK/STAT signaling, elevated autoantibodies, global remodeling, hypercytokinemia, interplay between these processes, clinical manifestations DS, potential therapeutic interventions remain ill...
Abstract Trisomy 21 causes Down syndrome, a condition characterized by cognitive impairments, immune dysregulation, and atypical morphogenesis. Using whole blood transcriptome analysis, we demonstrate that specific overexpression of four interferon receptors encoded on chromosome associates with chronic hyperactivity systemic inflammation in syndrome. To define the contribution receptor to syndrome phenotypes, used genome editing correct gene dosage mice carrying triplication large genomic...
Abstract Individuals with Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), display clear signs of immune dysregulation, including high rates autoimmune disorders and severe complications from infections. Although it is well established that T21 causes increased interferon responses JAK/STAT signaling, elevated autoantibodies, global remodeling, hypercytokinemia, interplay between these processes, clinical manifestations DS, potential therapeutic interventions remain ill...
Individuals with Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), display clear signs of immune dysregulation, including high rates autoimmune disorders and severe complications from infections. Although it is well established that T21 causes increased interferon responses JAK/STAT signaling, elevated autoantibodies, global remodeling, hypercytokinemia, interplay between these processes, clinical manifestations DS, potential therapeutic interventions remain ill defined....
Individuals with Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), display clear signs of immune dysregulation, including high rates autoimmune disorders and severe complications from infections. Although it is well established that T21 causes increased interferon responses JAK/STAT signaling, elevated autoantibodies, global remodeling, hypercytokinemia, interplay between these processes, clinical manifestations DS, potential therapeutic interventions remain ill defined....
Background: Individuals with Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), display clear signs of immune dysregulation, including high rates autoimmunity and severe complications from infections. Although it is well established that T21 causes increased interferon responses JAK/STAT signaling, elevated autoantibodies, global remodeling, hypercytokinemia, interplay between these processes, clinical manifestations DS, potential therapeutic interventions remain ill...
Cressa truxillensis, commonly known as alkali weed, is native to western North America and used in revegetation projects saline or alkaline soils at locations such the Ballona Wetlands Ecological Reserve. This research aimed (i) determine methods improve C. truxillensis seed germination, (ii) characterize impact salt has on germination growth, (iii) identify bacterial endophytes their potential plant growth promoting bacteria (PGPB). Results showed that scarification, either through...
Abstract People with Down syndrome (DS), the genetic condition caused by Trisomy 21 (T21), exhibit early appearance of Alzheimer’s disease (AD), likely due to triplication Amyloid Precursor Protein (APP) gene. However, impact many chromosome (HSA21) genes on AD phenotypes in context DS remains unknown. To test this, we conducted a detailed phenotypic characterization how AD-related neuropathology is modulated an extra copy orthologous HSA21 creating novel DS-AD mouse strain, crossing Dp16...