A5074547484- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Neonatal Respiratory Health Research
- Immune cells in cancer
- Nutrition and Health in Aging
- Adipose Tissue and Metabolism
- Per- and polyfluoroalkyl substances research
- Tracheal and airway disorders
- Cancer, Lipids, and Metabolism
- Cardiovascular Disease and Adiposity
- Pharmacological Effects and Toxicity Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Preterm Birth and Chorioamnionitis
- Immune Response and Inflammation
- Clinical Nutrition and Gastroenterology
- Cancer-related molecular mechanisms research
- Diet and metabolism studies
- Mesenchymal stem cell research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- RNA modifications and cancer
- Congenital Diaphragmatic Hernia Studies
- Cholesterol and Lipid Metabolism
- Fibroblast Growth Factor Research
- RNA Research and Splicing
- Lipid metabolism and disorders
Medical University of Vienna
2022-2024
The intestinal epithelium has a high turnover rate and constantly renews itself through proliferation of crypt cells, which depends on insufficiently characterized signals from the microenvironment. Here, we showed that colonic macrophages were located directly adjacent to epithelial cells in mice, where they metabolically supported cell an mTORC1-dependent manner. Specifically, deletion tuberous sclerosis complex 2 (Tsc2) activated mTORC1 signaling protected against colitis-induced damage...
lo , have a specific transcriptome, and proliferate in situ d decBAMs are inefficient APCs, induce Tregs, secrete IL-
Despite enormous efforts to improve therapeutic options, pancreatic cancer remains a fatal disease and is expected become the second leading cause of cancer-related deaths in next decade. Previous research identified lipid metabolic pathways be highly enriched ductal adenocarcinoma (PDAC) cells. Thereby, cholesterol uptake synthesis promotes growth advantage chemotherapy resistance for PDAC tumor Here, we demonstrate that high-density lipoprotein (HDL)-mediated efficient removal from cells...
Background/objectives: Nucleolin is a major component of the nucleolus and involved in various aspects ribosome biogenesis. However, it also implicated non-nucleolar functions such as cell cycle regulation proliferation, linking to pathologic processes. The aim this study was use differential gene expression analysis Weighted Gene Co-expression Network (WGCNA) identify nucleolin-related regulatory pathways possible key genes novel therapeutic targets for cancer, viral infections other...
A strong bidirectional link between metabolic and psychiatric disorders exists; yet, the molecular basis underlying this interaction remains unresolved. Here we explored role of brown adipose tissue (BAT) as modulatory interface, focusing on involvement uncoupling protein 1 (UCP-1), a key regulator highly expressed in BAT, control emotional behavior. Male female constitutive UCP-1 knock-out (KO) mice were used to investigate consequences deficiency anxiety-related depression-related...
PER: and polyfluoroalkyl substances (PFAS) are a large group of synthetic organic chemicals that ubiquitous environmental pollutants. Among PFAS, perfluorodecanoic acid (PFDA) is one the most toxic compounds, but molecular basis behind its toxicity not fully understood. In an interspecies comparison with placental cells (HTR-8/SVneo) zebrafish embryos, we demonstrate PFDA induces mitochondrial dysfunction impairs fatty β-oxidation. Reduced β-oxidation leads to less TCA cycle activity,...
Parenteral nutrition (PN) is frequently administered in palliative care patients suffering from cachexia. The evidence regarding the use of PN terminally ill scarce. Routine laboratory parameters might help to decide whether start or forgo PN, which could decrease overtreatment at end life. Kidney failure was associated with survival. However, a relation between kidney function and parenteral has not been observed thus far. aim this retrospective cohort study analyze under as well these overall
Abstract During human pregnancy, placenta-derived extravillous trophoblasts (EVT) invade the decidua and communicate with maternal immune cells. The can be distinguished into basalis (decB) parietalis (decP), latter being unaffected by placentation. By defining a novel gating strategy, we report accumulation of myeloid cells in decB. We identified basalis-associated macrophage (decBAM) population differential transcriptome secretome when compared to parietalis-associated macrophages...