A5012022094- Helicobacter pylori-related gastroenterology studies
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Lung Cancer Research Studies
- Cardiac tumors and thrombi
- Cardiovascular Health and Disease Prevention
- Neuroendocrine Tumor Research Advances
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Brain Metastases and Treatment
- Clinical Nutrition and Gastroenterology
- Meningioma and schwannoma management
- Neutropenia and Cancer Infections
- Chromatin Remodeling and Cancer
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Aortic aneurysm repair treatments
- Pain Management and Placebo Effect
- Thyroid Cancer Diagnosis and Treatment
- Vascular anomalies and interventions
- Hemiptera Insect Studies
- Clinical practice guidelines implementation
- Vascular Tumors and Angiosarcomas
- Bacterial Identification and Susceptibility Testing
- Cardiovascular Disease and Adiposity
Medical University Plovdiv
2024
Medical University of Vienna
2022-2024
Lomonosov Moscow State University
2017
Klinička bolnica "Sveti Duh"
2015
Institut za kardiovaskularne bolesti Dedinje
2014
University of Belgrade
2014
Immune checkpoint inhibitors (ICI) and tyrosine kinase (TKI) have gained therapeutical significance in cancer therapy over the last years. Due to high efficacy of each substance group, additive or complementary effects are considered, combinations subject multiple prospective trials different tumor entities. The majority available data results from clinical phase I II trials. Although regarded as well-tolerated therapies ICI-TKI higher toxicities compared monotherapies one classes some were...
Brain metastases (BM) in patients with thyroid cancer (TC) are rare an incidence of 1% for papillary and follicular, 3% medullary up to 10% anaplastic TC (PTC, FTC, MTC ATC). Little is known about the characteristics management BM from TC. Thus, we retrospectively analyzed histologically verified radiologically identified Vienna Metastasis Registry. A total 20/6074 included database since 1986 had 13/20 were female. Ten 8 PTC, one ATC. The median age at diagnosis was 68 years. All but...
The aim of this study was to determine the distribution major risk factors among patients with atherosclerotic disease aged ≤50 years.The population comprised 944 years clinically significant manifestations compared 350 consecutive (control) older (age >50 years).The most for supra-aortic branches were: smoking (87.5%, p < 0.001), family history atherosclerosis (52.3%, diabetes mellitus (28.5%) and being male (56.9%) (p 0.05 both). In coronary artery disease, there considerable disparity in...
The chemotherapy regimen capecitabine/temozolomide (CAPTEM) is routinely used in neuroendocrine tumors (NET), with antitumor activity particularly demonstrated pancreatic or high-grade neoplasms (NEN). However, different dosing regimens are used, and the optimal schedule remains to be defined. This single-center retrospective analysis assessed efficacy safety of CAPTEM patients NEN using a starting both compounds simultaneously (temozolomide on days 1–5 capecitabine 1–14 28-day cycle) rather...
Using machine learning methods based on neurocognitive deficits and neuroimmune biomarkers, two distinct classes were discovered within schizophrenia patient samples. Increased frequency of psychomotor retardation, formal thought disorders, mannerisms, psychosis, hostility, excitation, negative symptoms defined the first subgroup, major psychosis (MNP). Cognitive in executive functions memory diverse aberrations other MNP features. Simple (SNP) was less severe phenotype.
Abstract Background Using machine learning methods based on neurocognitive deficits and neuroimmune biomarkers, two distinct classes were discovered within schizophrenia patient samples. The first, major psychosis (MNP) was characterized by cognitive in executive functions memory, higher prevalence of psychomotor retardation, formal thought disorders, mannerisms, psychosis, hostility, excitation, negative symptoms, diverse aberrations. Simple (SNP) the less severe phenotype. Aims study...
Summary SMARCA4-deficient undifferentiated tumor (SMARCA4-UTs) is an extremely rare and aggressive entity where no consensus on systemic treatment exists to date. We report the case of a 43-year-old woman with thoracic SMARCA4-UT who presented rapid progression disease after surgical resection achieved complete radiologic remission under VDC-IE chemotherapy (vincristine, doxorubicin, cyclophosphamide [VDC], alternating ifosfamide etoposide [IE]). The detailed followed by brief discussion...
Summary Febrile neutropenia (FN) is a common oncologic emergency where quick patient assessment and prompt initiation of antimicrobial treatment crucial. Guidelines provide detailed recommendations on prevention treatment; however, their real-world implementation can prove to be difficult. Score systems for outcome risk are effective in identifying low-risk patients with FN. After therapy, regular re-evaluation necessary, further diagnostic studies should tailored each patient. Use...
Abstract Large cell neuroendocrine carcinoma (LCNEC) of the lung is an aggressive malignancy, with brain metastases (BM) occurring in approximately 20% cases. There are currently no therapy guidelines for this population as only few data on management LCNEC and BM have been published. For retrospective single center study, patients were identified from Vienna Brain Metastasis Registry. Data clinicopathological features, BM-specific characteristics, treatment, outcome extracted. In total,...
Background/Aim: Soft tissue sarcomas are rare and heterogenous malignancies with high recurrence rates following resection a poor prognosis in advanced stages. Eribulin is used metastatic soft sarcoma patients, who have failed first line chemotherapy has been approved for patients pretreated liposarcoma (LPS) the United States Europe publication of data phase III trial. In addition, no available eribulin as postoperative treatment after potentially curative surgery. We, thus, retrospectively...
Parenteral nutrition (PN) is frequently administered in palliative care patients suffering from cachexia. The evidence regarding the use of PN terminally ill scarce. Routine laboratory parameters might help to decide whether start or forgo PN, which could decrease overtreatment at end life. Kidney failure was associated with survival. However, a relation between kidney function and parenteral has not been observed thus far. aim this retrospective cohort study analyze under as well these overall
Defining standards for establishing a new vascular surgery center is very important in order to ensure its proper functioning. Multidisciplinary approach crucial optimal functionality of the center. Organizational and technical guidelines should be based on experience well-established recognized centers. The aim this paper highlight basic needs requirements creation with special emphasis quality cooperation between different specialties.
Disseminated intravascular coagulation (DIC) represents a pathological activation of (blood clotting) mechanisms that happens in response to variety diseases. Diseases the blood vessels, such as aorta aneurysmal disease, could also cause local coagulation. We report case DIC patient after surgery abdominal aneurysm. 64-year-old woman was admitted Clinic for vascular diagnosis and surgical treatment Multidetector computed tomography (MDCT) angiography verified aneurysm 5.2 cm diameter with...
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