Major depressive disorder (MDD) is one of the most debilitating psychiatric diseases, affecting a large percentage population worldwide. Currently, underlying pathomechanisms remain incompletely understood, hampering development critically needed alternative therapeutic strategies, which further largely depends on availability suitable model systems. Here we used mouse early life stress – precipitating factor for MDD featuring infectious through maternal immune activation (MIA) by...

The effects of resveratrol (RES) in heart failure have already been evaluated animal models; however, human clinical trials, they not confirmed yet. aim this study was to assess the treatment systolic patients (heart with reduced ejection fraction or HFrEF). In trial, 60 outpatients NYHA (New York Heart Association) class II-III HFrEF were enrolled and randomized into two groups: receiving either 100-mg daily placebo for three months. At beginning at end echocardiography, a six-minute walk...

Excessive fear learning and generalized, extinction-resistant memories are core symptoms of anxiety trauma-related disorders. Despite significant evidence from clinical studies reporting hyperactivity the bed nucleus stria terminalis (BNST) under these conditions, role BNST in expression is still not clarified. Here, we tested how modulates male mice using a chemogenetic approach. Activation GABAergic neurons during conditioning or memory consolidation resulted enhanced cue-related recall....

During oxidative stress mitochondria become the main source of endogenous reactive oxygen species (ROS) production. In present study, we aimed to clarify effects pharmacological PARP-1 inhibition on mitochondrial function and quality control processes.

Abstract The signal transducer and activator of transcription 3 (STAT3) signalling pathway is activated through phosphorylation by Janus kinases in response to a diverse set immunogenic non-immunogenic triggers. Several distinct lines evidence propose an intricate involvement STAT3 neural function relevant behaviour health disease. However, part due the pleiotropic effects resulting from its DNA binding activity consequent regulation expression variety genes with context-dependent cellular...

Heart failure (HF) is a complex clinical syndrome with poor outcomes despite the growing number of therapeutic approaches. It characterized by interstitial fibrosis, cardiomyocyte hypertrophy, activation various intracellular signalling pathways, and damage mitochondrial network. Mitochondria are responsible for supplying energy demand cardiomyocytes; therefore, network causes cellular dysfunction finally leads to cell death. BGP‐15, hydroxylamine derivative, an insulin‐sensitizer molecule...

A strong bidirectional link between metabolic and psychiatric disorders exists; yet, the molecular basis underlying this interaction remains unresolved. Here we explored role of brown adipose tissue (BAT) as modulatory interface, focusing on involvement uncoupling protein 1 (UCP-1), a key regulator highly expressed in BAT, control emotional behavior. Male female constitutive UCP-1 knock-out (KO) mice were used to investigate consequences deficiency anxiety-related depression-related...

Maternal immune activation (MIA) during pregnancy impacts offspring neurodevelopmental trajectories and induces lifelong consequences, including emotional cognitive alterations. Using the polyinosinic:polycytidilic acid (PIC) MIA model we have previously demonstrated enhanced depression-like behavior in adult offspring, which was associated with reduced expression of vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2) hippocampus. Since VEGF mediates effects various antidepressant...

The highly conserved transcription factor LIM-only 3 (Lmo3) is involved in important neurodevelopmental processes several brain areas including the amygdala, a central hub for generation and regulation of emotions. Accordingly, role Lmo3 behavioral responses to ethanol display anxiety-like behavior mice has been demonstrated while potential involvement control mood-related not yet explored. Using mouse model depletion (Lmo3z), we here report that genetic deficiency associated with altered...

<i>Background/Aims:</i> Recently organ-saving procedures have become popular in the treatment of chronic pancreatitis with head enlargement. The purpose this study is to compare results three different procedures. <i>Methods:</i> Between 1991 and 1998, 32 Beger operations, 13 Frey 21 pylorus-preserving pancreatoduodenectomies (PPPDs) were performed. pre-, intra- postoperative data detailed. During follow-up examination quality life, body weight, consumption alcohol...

The characteristics of the cycles activity and rest stand out among most intensively investigated aspects circadian rhythmicity in humans experimental animals. Alterations patterns are strongly linked to cognitive emotional dysfunctions severe mental illnesses such as Alzheimer's disease (AD) major depression (MDD). proinflammatory cytokine interleukin 6 (Il-6) has been prominently associated pathogenesis AD MDD. However, potential involvement Il-6 modulation diurnal rhythms have not...

It is known that non-steroidal anti-inflammatory drugs increase cardiovascular (CV) morbidity and mortality. In this study, we examined whether a novel drug, bradykinin B1 receptor antagonist (FGY-1153) treatment could influence the development of hypertensive organ damages in spontaneously rats (SHR). SHRs were treated with low (FGY-120) or high dose FGY-1153 (FGY-400) placebo (Control) for 26 weeks. Wistar-Kyoto used as aged-matched, normotensive controls (WKY). Body weight, food...

Heart failure (HF) is a complex chronic clinical disease characterized by among others the damage of mitochondrial network. The disruption quality control and imbalance in fusion‐fission processes lead to lack energy supply and, finally, cell death. BGP‐15 (O‐[3‐piperidino‐2‐hydroxy‐1‐propyl]‐nicotinic acid amidoxime dihydrochloride) an insulin sensitizer molecule has cytoprotective effect wide variety experimental models. In our recent work, we aimed clarify protective effects...

Epidemiological studies indicate a bidirectional association between metabolic disturbances, including obesity and related pathological states, mood disorders, most prominently major depression. However, the biological mechanisms mediating comorbid relationship deranged states remain incompletely understood. Here, we tested hypothesis that enhanced activation of brown fat tissue (BAT), known to beneficially regulate accompanying dysfunctional is also paralleled by an alteration affective...

Mitochondria form a dynamic network in cells, regulated by the balance between mitochondrial fusion and fission. The inhibition of fission can have positive effects acute ischemic/reperfusion injury models preventing fall membrane potential associated with processes. However, chronic is disadvantageous because it obstructs elimination damaged fragments. OPA1, view previous results, possible therapeutic target as promoter structure stabilizer protein. We used transgenic mice which OMA1...

The 21st Century innovation trends have reached forensic science, too and new devices for law enforcement appear every day. changing of this phenomena raises many questions. How reliable are the devices? Do they replace previous methods, technical background? we need further improvements, or do to adapt present ones challenges crime investigation? Dogs been used centuries several purposes by mankind, including tracking methods. develop artificial noses, analytical instruments match trends?...

Abstract Introduction Mitochondria forms a dynamic network in cells, which is regulated by the balance between mitochondrial fusion and fission. The inhibition of fission could result positive effects acute ischemic/reperfusion injury models, due to prevention membrane potential fall that goes along with processes. However, chronic models disadvantageous because it obstructs elimination damaged fragments. OPA1 – view previous results possible therapy target, as promoter structure stabilizer...

Introduction: Epiphrenic diverticula are very rarely seen and often associated with achalasia, oesophageal body dysmotility a high resting lower sphincter pressure.

The risk of developing neoplasia is significantly increased in patients with long-standing ulcerative colitis. Intraepithelial might arise from flat, endoscopically invisible lesions or may appear as DALM. latter should be separated adenoma-like mass (ALM), since the two entities require different management.