A5101421102- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Nonmelanoma Skin Cancer Studies
- Cannabis and Cannabinoid Research
- Syphilis Diagnosis and Treatment
- Cutaneous Melanoma Detection and Management
- Neural dynamics and brain function
- Pancreatitis Pathology and Treatment
- Blood disorders and treatments
- Cancer Treatment and Pharmacology
- Autoimmune Bullous Skin Diseases
- Cancer and Skin Lesions
- Neurotransmitter Receptor Influence on Behavior
- Antibiotics Pharmacokinetics and Efficacy
- Neurological disorders and treatments
- Olfactory and Sensory Function Studies
- Animal Vocal Communication and Behavior
- Tryptophan and brain disorders
- Functional Brain Connectivity Studies
- Cutaneous lymphoproliferative disorders research
- Neuroblastoma Research and Treatments
- Complementary and Alternative Medicine Studies
- Essential Oils and Antimicrobial Activity
HUN-REN Institute of Experimental Medicine
2012-2025
Hungarian Research Network
2024
Neuroscience Institute
2024
Czech Academy of Sciences, Institute of Experimental Medicine
2019-2023
Semmelweis University
2007-2020
Hungarian Academy of Sciences
2016-2019
University of Pecs
2005
University of Freiburg
2000
Center for Brooklyn History
1973-1990
Long Island Skin Cancer and Dermatologic Surgery
1986
A single exposure to a stressful event can result in enduring changes behaviour. Long-term modifications neuronal networks induced by stress are well explored but the initial steps leading these alterations remain incompletely understood. In this study, we found that acute triggers an immediate increase firing activity of calretinin-positive neurons paraventricular thalamic nucleus (PVT/CR+) persists for several days mice. This had causal role stress-induced spontaneous Attenuating PVT/CR+...
An important question in behavioral neurobiology is how particular neuron populations and pathways mediate the overall roles of brain structures. Here we investigated this issue by studying medial prefrontal cortex (mPFC), an established locus inhibitory control aggression. We male rats that dominantly distinct mPFC project to produce dense fiber networks with glutamate release sites mediobasal hypothalamus (MBH) lateral (LH; i.e., two executory centers species-specific violent bites,...
As previously shown, rats isolated from weaning develop abnormal social and aggressive behavior characterized by biting attacks targeting vulnerable body parts of opponents, reduced attack signaling, increased defensive despite counts. Here we studied whether this form violent aggression could be reversed resocialization in adulthood. During the first weak resocialization, isolation-reared showed multiple deficits including defensiveness decreased huddling during sleep. Deficits were...
Endothelial dysfunction is characterized by decreased vasodilatory capacity of the arterioles mainly due to reduced release nitric oxide (NO). Application NO donors may prevent or even reverse consequences endothelial dysfunction, such as diabetic leg ulcers.To investigate and possible side-effects topical application an donor-containing hydrogel in rats.S-nitrosoglutathione (GSNO) was incorporated Pluronic F127 applied on foot sole skin healthy streptozotocin-induced rats. Blood flow...
Excessive fear learning and generalized, extinction-resistant memories are core symptoms of anxiety trauma-related disorders. Despite significant evidence from clinical studies reporting hyperactivity the bed nucleus stria terminalis (BNST) under these conditions, role BNST in expression is still not clarified. Here, we tested how modulates male mice using a chemogenetic approach. Activation GABAergic neurons during conditioning or memory consolidation resulted enhanced cue-related recall....
Aggression is a complex behavior influenced by developmental experiences, internal state, and social context, yet its neurobiological underpinnings remain insufficiently understood. The serotonergic system, particularly the serotonin transporter (SERT), plays crucial role in aggression regulation. Here, we investigated region-specific, dynamic changes SERT expression following aggressive interactions mice subjected to early-life adversity. We found that encounters (resident-intruder test)...
Anxiety and trauma-related disorders are characterized by significant alterations in threat detection, resulting inadequate fear responses evoked weak threats or safety stimuli. Recent research pointed out the important role of bed nucleus stria terminalis (BNST) anticipation modulation under ambiguous threats, hence, exaggerated may be traced back to altered BNST function. To test this hypothesis, we chemogenetically inhibited specific neuronal populations (corticotropin-releasing hormone -...
Physical examination of a patient yielded cutaneous findings suggestive lymphoma or sarcoidosis. A roentgenogram the chest revealed nodular infiltrates at bases both lungs, lending support for diagnosis On biopsy, skin lesions showed noncaseating granulomata. The correct syphilis was first suspected on basis reactive Venereal Disease Research Laboratory test. Clinically, atypical forms may be rise because short-term antibiotic treatment given to patients during incubation period disease.
Adverse social experiences during childhood increase the risk of developing aggression-related psychopathologies. The prefrontal cortex (PFC) is a key regulator behavior, where experience-dependent network development tied to maturation parvalbumin-positive (PV+) interneurons. Maltreatment in could impact PFC and lead disturbances behavior later life. However, our knowledge regarding early-life stress on operation PV+ cell function still scarce. Here, we used post-weaning isolation (PWSI)...
Nineteen hospitalized women postoperatively suffered from severe burns of the buttocks and back contact with reusable surgical gowns drapes that had been sterilized ethylene oxide not properly aerated. Initially, an "epidemic" bullous impetigo was suspected. Severe irritant reactions to detergents antiseptics were also considered. The burnt skin resembled a localized form Lyell disease. This report is alert dermatologists so prompt action may be taken prevent widespread outbreaks burns.
Traumatic experiences result in the development of posttraumatic stress disorder (PTSD) 10-25% exposed individuals. While human clinical studies suggest that susceptibility is potentially linked to endocannabinoid (eCB) signaling, neurobiological PTSD factors are poorly understood. Employing a rat model contextual conditioned fear, we characterized distinct resilient and susceptible subpopulations based on lasting generalized core symptom PTSD. In these groups, assessed i.) eCB levels by...
Nineteen hospitalized women postoperatively suffered from severe burns of the buttocks and back contact with reusable surgical gowns drapes that had been sterilized ethylene oxide not properly aerated. Initially, an "epidemic" bullous impetigo was suspected. Severe irritant reactions to detergents antiseptics were also considered. The burnt skin resembled a localized form Lyell disease. This report is alert dermatologists so prompt action may be taken prevent widespread outbreaks burns.
A patient with discoid lupus erythematosus associated rheumatoid arthritis is reported. The developed aplastic anemia in the third month of administration quinacrine and subsequently died as a result massive cerebral hemorrhage. Attempts to demonstrate an auto- or quinacrine-induced immune mechanism were unsuccessful. literature induced reviewed. In light this other reports, cautious hematological surveillance seems indicated prolonged quinacrine.