A5051481523- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Nicotinic Acetylcholine Receptors Study
- Sleep and Wakefulness Research
- Neuroscience and Neural Engineering
- Receptor Mechanisms and Signaling
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Neurobiology and Insect Physiology Research
- Plant and Biological Electrophysiology Studies
- Cognitive Science and Mapping
- Parkinson's Disease Mechanisms and Treatments
- Neuroendocrine regulation and behavior
- Circadian rhythm and melatonin
- Nerve injury and regeneration
- Neural and Behavioral Psychology Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Insect Resistance and Genetics
- Neurological disorders and treatments
- Insect behavior and control techniques
- Vestibular and auditory disorders
HUN-REN Institute of Experimental Medicine
2016-2025
Hungarian Academy of Sciences
2011-2024
Czech Academy of Sciences, Institute of Experimental Medicine
2019-2024
Neuroscience Institute
2023-2024
Cold Spring Harbor Laboratory
2012-2016
The more we anticipate a response to predictable stimulus, the faster react. This empirical observation has been confirmed and quantified by many investigators suggesting that processing of behaviorally relevant stimuli is facilitated probability-based confidence anticipation. However, exact neural mechanisms underlying this phenomenon are largely unknown. Here show performance changes related different levels expectancy originate in dynamic modulation delta oscillation phase. Our results...
Information processing in the hippocampus critically relies on its reciprocal interaction with medial septum (MS). Synchronization of septo-hippocampal system was demonstrated during both major hippocampal activity states, regular theta rhythm and large amplitude irregular activity. Previous experimental modeling data suggest that MS provides rhythmic drive to hippocampus, hippocampo-septal feedback synchronizes septal pacemaker units. However, this view has recently been questioned based...
Ascending and descending information is relayed through the thalamus via strong, "driver" pathways. According to our current knowledge, different driver pathways are organized in parallel streams do not interact at thalamic level. Using an electron microscopic approach combined with optogenetics vivo physiology, we examined whether inputs arising from sources can single thalamocortical cells rodent somatosensory (nucleus posterior, POm). Both anatomical physiological data demonstrated that...
Microglia, the main immunocompetent cells of brain, regulate neuronal function, but their contribution to cerebral blood flow (CBF) regulation has remained elusive. Here, we identify microglia as important modulators CBF both under physiological conditions and during hypoperfusion. Microglia establish direct, dynamic purinergic contacts with in neurovascular unit that shape mice humans. Surprisingly, absence or blockade microglial P2Y12 receptor (P2Y12R) substantially impairs coupling mice,...
Cortical information processing is under state-dependent control of subcortical neuromodulatory systems. Although this modulatory effect thought to be mediated mainly by slow nonsynaptic metabotropic receptors, other mechanisms, such as direct synaptic transmission, are possible. Yet, it currently unknown if any form exists. Here, we present evidence a strong, spatiotemporally precise excitatory input from an ascending center. Selective stimulation serotonergic median raphe neurons produced...
The medial septum (MS) is an indispensable component of the subcortical network which synchronizes hippocampus at theta frequency during specific stages information processing. GABAergic neurons exhibiting highly regular firing coupled to hippocampal rhythm are thought form core MS rhythm-generating network. In recent studies hyperpolarization-activated, cyclic nucleotide-gated non-selective cation (HCN) channel was shown participate in synchronization septum. Here, we tested hypothesis that...
Decision confidence is a forecast about the probability that decision will be correct. From statistical perspective, can defined as Bayesian posterior chosen option correct based on evidence contributing to it. Here, we used this formal definition starting point develop normative framework for confidence. Our goal was make general predictions do not depend structure of noise or specific algorithm estimating We analytically proved several interrelations between and observable measures, such...
A single exposure to a stressful event can result in enduring changes behaviour. Long-term modifications neuronal networks induced by stress are well explored but the initial steps leading these alterations remain incompletely understood. In this study, we found that acute triggers an immediate increase firing activity of calretinin-positive neurons paraventricular thalamic nucleus (PVT/CR+) persists for several days mice. This had causal role stress-induced spontaneous Attenuating PVT/CR+...
Sense organs are often actively controlled by motor processes and such active sensing profoundly shapes the timing of sensory information flow. The temporal coordination between different is less well understood but essential for multisensory integration, brain regions, energetically optimal sampling strategies. Here we studied sniffing whisking, in rodents that control acquisition smell touch information, respectively. Sniffing, high-frequency respiratory bouts, rapid back forth movements...
GABA-A receptors (GABA-ARs) are typically expressed at synaptic or nonsynaptic sites mediating phasic and tonic inhibition, respectively. These two forms of inhibition conjointly control various network oscillations. To disentangle their roles in thalamocortical rhythms, we focally deleted synaptic, γ2 subunit-containing GABA-ARs the thalamus using viral intervention mice. After successful removal subunit clusters, spontaneous evoked GABAergic currents disappeared cells when presynaptic,...
Episodic learning and memory retrieval are dependent on hippocampal theta oscillation, thought to rely the GABAergic network of medial septum (MS). To test how this achieves synchrony, we recorded MS neurons local field potential simultaneously in anesthetized awake mice rats. We show that pacemakers synchronize their individual rhythmicity frequencies, akin coupled pendulum clocks as observed by Huygens. optogenetically identified them parvalbumin-expressing neurons, while glutamatergic...
Studying animal models furthers our understanding of Parkinson's disease (PD) pathophysiology by providing tools to investigate detailed molecular, cellular and circuit functions. Different versions the neurotoxin-based 6-hydroxydopamine (6-OHDA) model PD have been widely used in rats. However, these typically assess result extensive definitive dopaminergic lesions that reflect a late stage PD, leading paucity studies consequential gap knowledge regarding initial stages, which early...
Abstract Acetylcholine (Ach) is released by the cholinergic basal forebrain (CBF) throughout cortical mantle and implicated in behavioral functions ranging from arousal to attention learning. Yet what signal ACh provides cortex remains unresolved, hindering our understanding of its functional roles. Here we demonstrate that CBF signals unsigned reinforcement prediction error, contrast dopamine (DA) neurons encode reward error. We show both neuronal activity acetylcholine (ACh) release at...
The exact timing of cortical afferent activity is instrumental for the correct coding and retrieval internal external stimuli. Thalamocortical inputs represent most significant subcortical pathway to cortex, but precise temporal variability thalamocortical not known. To examine this question, we studied phase thalamic action potentials relative oscillations established correlations among phase, nuclear location neurons, frequency activity. depended on slow oscillation both long (minutes)...
Earlier work on freely moving rats classified neurons in Ammon's horn as pyramidal cells (including place cells) or interneurons (previously called "theta cells") based temporal discharge correlates and waveform configurations, but the anatomical biochemical diversity of suggests they may have other distinguishing characteristics. To explore this possibility, we made extracellular recordings foraged for food an open space, used accepted criteria to identify interneurons, found two additional...
Abstract Infrared neural stimulation is a promising tool for stimulating the brain because it can be used to excite with high spatial precision without need of delivering or inserting any exogenous agent into tissue. Very few studies have explored its use in brain, as most investigations focused on sensory motor nerve stimulation. Using intravital calcium imaging genetically encoded indicator GCaMP6f, here we show that application infrared induces intracellular signals Layer 2/3 neurons...