A5053804999- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Cannabis and Cannabinoid Research
- Photoreceptor and optogenetics research
- Sleep and Wakefulness Research
- Neuroscience and Neural Engineering
- Marine animal studies overview
- Animal Vocal Communication and Behavior
- GABA and Rice Research
- Circadian rhythm and melatonin
- Plant and Biological Electrophysiology Studies
- Olfactory and Sensory Function Studies
- EEG and Brain-Computer Interfaces
- Genetics and Neurodevelopmental Disorders
- Neurotransmitter Receptor Influence on Behavior
- Regulation of Appetite and Obesity
- Animal Genetics and Reproduction
- Anesthesia and Neurotoxicity Research
- Nicotinic Acetylcholine Receptors Study
- Viral Infections and Immunology Research
- Polynomial and algebraic computation
- Neurogenesis and neuroplasticity mechanisms
- Advanced Differential Equations and Dynamical Systems
HUN-REN Institute of Experimental Medicine
2004-2025
HUN-REN Research Centre for Natural Sciences
2017-2022
University of Veterinary Medicine
2019-2022
Czech Academy of Sciences, Institute of Experimental Medicine
2007-2022
Hungarian Academy of Sciences
2004-2019
Institute of Cognitive Neuroscience and Psychology
2017-2019
École Polytechnique Fédérale de Lausanne
2010
Classical studies of mammalian movement control define a prominent role for the primary motor cortex. Investigating mouse whisker system, we found an additional and equally direct pathway cortical driven by somatosensory Whereas activity in cortex directly evokes exploratory protraction, drives retraction, providing rapid negative feedback signal sensorimotor integration. Motor sensory suggests need to reevaluate functional organization maps.
Abstract Neural probes designed for extracellular recording of brain electrical activity are traditionally implanted with an insertion speed between 1 µm/s and mm/s into the tissue. Although physical effects on tissue well studied, there is a lack research investigating how quality acquired electrophysiological signal depends probe insertion. In this study, we used four different speeds (0.002 mm/s, 0.02 0.1 mm/s) to implant high-density silicon deep layers somatosensory cortex...
Sleep spindles are major transient oscillations of the mammalian brain. Spindles generated in thalamus; however, what determines their duration is presently unclear. Here, we measured somatic activity excitatory thalamocortical (TC) cells together with axonal reciprocally coupled inhibitory reticular thalamic (nRTs) and quantified cycle-by-cycle alterations firing vivo. We found that different durations were paralleled by distinct nRT activity, sharply dropped before termination all...
An inhibitor causes neuronal excitation Glycine is thought to be primarily an inhibitory neurotransmitter. However, it also acts as a coagonist on excitatory N -methyl-D-aspartate (NMDA) receptors. Otsu et al. examined the function of NMDA receptor subunit combination GluN1/GluN3A in medial habenula (MHb) adult mice. This MHb neurons activated by glycine released from astrocytes. Activation receptors depolarization and increased spiking neurons. Reducing GluN3A levels blocks conditioned...
Major cognitive and emotional faculties are dominantly lateralized in the human cerebral cortex. The mechanism of this lateralization has remained elusive owing to inaccessibility brains many experimental manipulations. In study we demonstrate hemispheric observational fear learning mice. Using unilateral inactivation as well electrical stimulation anterior cingulate cortex (ACC), show that is controlled by right but not left ACC. contrast cortex, either or thalamic nuclei, both which...
Abstract A large forebrain circuit, including the thalamus, amygdala and frontal cortical regions, is responsible for establishment extinction of fear‐related memories. Understanding interactions among these three regions critical to deciphering basic mechanisms fear. With advancement molecular optogenetics techniques, mouse has become main species used study behaviours. However, connectivity pattern circuits involved in processing fear not been described this species. In we mapped between...
GABA-A receptors (GABA-ARs) are typically expressed at synaptic or nonsynaptic sites mediating phasic and tonic inhibition, respectively. These two forms of inhibition conjointly control various network oscillations. To disentangle their roles in thalamocortical rhythms, we focally deleted synaptic, γ2 subunit-containing GABA-ARs the thalamus using viral intervention mice. After successful removal subunit clusters, spontaneous evoked GABAergic currents disappeared cells when presynaptic,...
Cannabinoid ligands show therapeutic potential in a variety of disorders including anxiety. However, the anxiety-related effects cannabinoids remain controversial as agonists opposite mice and rats. Here we compared cannabinoid agonist WIN-55,212 CB1 antagonist AM-251 CD1 Wistar Special attention was paid to antagonist-agonist interactions, which had not yet been studied In mice, decreased whereas increased The abolished agonist. contrast, anxiety Surprisingly, potentiated this effect....
Abstract The number and distribution of excitatory inhibitory inputs affect the integrative properties neurons. These parameters have been studied recently for several hippocampal neuron populations. Besides parvalbumin‐ (PV) containing cells that include basket axo‐axonic cells, cholecystokinin (CCK)‐containing interneurons also form a cell population with distinct from PV cells. Here, at light microscopic level, we reconstructed entire dendritic tree CCK‐immunoreactive (IR) to describe...
Abstract Transgenic mice are overtaking the role of model animals in neuroscience. They used developmental, anatomical, and physiological as well experimental neurology. However, most results on organization nervous system derive from rat. The rat hippocampus its neuronal elements have been thoroughly investigated, revealing remarkable functional morphological diversity specificity among hippocampal interneurons. Our aim was to examine properties distinct interneuron populations, i.e., those...
Abstract Adeno-associated virus (AAV) gene therapy is often limited by pre-existing neutralizing antibodies (NAbs), yet current assays for NAb detection lack standardization and rarely quantify uncertainty, complicating cross-study comparisons. We present coreTIA (core Transduction Inhibition Assay), a modular experimental protocol combined with statistically robust analysis pipeline that delivers precise, reproducible titers quantified uncertainty every result. coreTIA’s statistical...
Prefrontal cortical influence over the mesolimbic system - including nucleus accumbens (NAc) and ventral tegmental area (VTA) is implicated in various cognitive processes behavioral malfunctions. The functional versatility of this could be explained by an underlying anatomical complexity; however, detailed characterization medial prefrontal (mPFC) innervation NAc VTA still lacking. Therefore, combining classical retrograde conditional viral tracing techniques with multiple fluorescent...