A5009613516- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Historical Studies and Socio-cultural Analysis
- Olfactory and Sensory Function Studies
- Sleep and Wakefulness Research
- Epilepsy research and treatment
- Neuroscience and Neural Engineering
- Vietnamese History and Culture Studies
- European Political History Analysis
- French Historical and Cultural Studies
- EEG and Brain-Computer Interfaces
- Geology and Paleoclimatology Research
- Neurobiology and Insect Physiology Research
- Ion channel regulation and function
- Autism Spectrum Disorder Research
- Historical and Contemporary Political Dynamics
- Genomic variations and chromosomal abnormalities
- Genetics and Neurodevelopmental Disorders
- Psychoanalysis and Psychopathology Research
- Historical and Architectural Studies
- History, Culture, and Diplomacy
- Protein Structure and Dynamics
- RNA Research and Splicing
- Neuroscience of respiration and sleep
Collège de France
2025
Centre National de la Recherche Scientifique
2007-2023
Cardiff University
2013-2023
Centre de Recherche en Neurosciences de Lyon
2015-2023
Université Claude Bernard Lyon 1
2007-2023
Inserm
2015-2023
Centre Neurosciences intégratives et Cognition
2020-2023
Université Paris Cité
2021-2023
Centre Hospitalier Le Vinatier
2015-2021
Lyon College
2020
Slow waves represent one of the prominent EEG signatures non-rapid eye movement (non-REM) sleep and are thought to play an important role in cellular network plasticity that occurs during this behavioral state. These slow natural currently considered be exclusively generated by intrinsic synaptic mechanisms within neocortical territories, although a for thalamus key physiological rhythm has been suggested but never demonstrated. Combining neuronal ensemble recordings, microdialysis,...
Absence seizures are brief episodes of impaired consciousness, behavioral arrest, and unresponsiveness, with yet-unknown neuronal mechanisms. Here we report that an awake female rat model recapitulates the behavioral, electroencephalographic, cortical functional magnetic resonance imaging characteristics human absence seizures. Neuronally, feature overall decreased but rhythmic firing neurons in cortex thalamus. Individual thalamic express one four distinct patterns seizure-associated...
The thalamic output during different behavioral states is strictly controlled by the firing modes of thalamocortical neurons. During sleep, their hyperpolarized membrane potential allows activation T-type calcium channels, promoting rhythmic high-frequency burst that reduces sensory information transfer. In contrast, in waking state neurons mostly exhibit action potentials at low frequency (i.e., tonic firing), enabling reliable transfer incoming inputs to cortex. Because nearly complete...
Absence seizures (ASs) are the hallmark of childhood/juvenile absence epilepsy. Monotherapy with first-line anti-absence drugs only controls ASs in 50% patients, indicating need for novel therapeutic targets. Since serotonin family-2 receptors (5-HT2Rs) known to modulate neuronal activity cortico-thalamo-cortical loop, main network involved AS generation, we investigated effect selective 5-HT2AR and 5-HT2CR ligands on Genetic Epilepsy Rats from Strasbourg (GAERS), a well established...
Gamma (∼40-90 Hz) and beta (∼15-40 oscillations their associated neuronal assemblies are key features of sensory processing. However, the mechanisms involved in either interaction and/or switch between these different regimes most systems remain misunderstood. Based on vivo recordings biophysical modeling mammalian olfactory bulb (OB), we propose a general scheme where OB internal dynamics can sustain two distinct dynamic states, each dominated by gamma or regime. The occurrence regime...
Abstract A growing body of data suggests that information coding can be achieved not only by varying neuronal firing rate, but also spike timing relative to network oscillations. In the olfactory bulb (OB) a freely breathing anaesthetized mammal, odorant stimulation induces prominent oscillatory local field potential (LFP) activity in beta (10–35 Hz) and gamma (40–80 ranges, which alternate during respiratory cycle. At same time, mitral/tufted (M/T) cells display respiration‐modulated...
T-type calcium channel isoforms expressed in heterologous systems demonstrate marked differences the biophysical properties of resulting currents. Such heterogeneity gating behaviour not only reflects structural but is also observed following regulation activity by a number ligands. However, physiological impact these parameters T channels has never been evaluated situ where unique interplay between and other intrinsic currents conserved, activation can be triggered synaptic stimulation....
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and the <i>I</i><sub>h</sub> current they generate contribute to pathophysiological mechanisms of absence seizures (ASs), but their precise role in neocortical thalamic neuronal populations, main components network underlying AS generation, remains controversial. In diverse genetic models, amplitude is smaller neurons either larger or unchanged thalamocortical (TC) compared with nonepileptic strains. A lower expression HCN...
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are known to be involved in the generation of absence seizures (ASs), and there is evidence that cortical thalamic HCN channel dysfunctions may have a proabsence role. Many blockers available, but their role ASs has been investigated only by localized brain injection or vitro model systems due limited availability. Here, we effect on orally administered ivabradine (an blocker approved for treatment heart failure humans)...
Local field potential (LFP) oscillations are often accompanied by synchronization of activity within a widespread cerebral area. Thus, the LFP and neuronal coherence appear to be result common mechanism that underlies assembly formation. We used olfactory bulb as model investigate: (1) extent which unitary dynamics can correlated (2) precision with hypothesized underlying mechanisms accurately explain experimental data. For this purpose, we analyzed simultaneous recordings mitral cell (MC)...
Abstract It is an uninformative truism to state that the brain operates at multiple spatial and temporal scales, each with own set of emergent phenomena. More worthy attention point our current understanding it cannot clearly indicate which these phenomenological scales are significant contributors brain’s function primary output (i.e. behaviour). Apart from sheer complexity problem, a major contributing factor this affairs lack instrumentation can simultaneously address without causing...
This paper reports on the development, characterization and in vivo validation of compact optical neural probes. These novel intracerebral devices comprise micro light-emitting diodes ( μLEDs) integrated along their slender probe shanks with up to 20 μLEDs per device. Blue light a peak wavelength 455 nm is emitted from circular apertures 100 μm diameter. The are structured GaN-on-sapphire wafers subsequently transferred onto silicon (Si) carrier wafers. wafer-scale transfer process provides...
The advent of optogenetics has given neuroscientists the opportunity to excite or inhibit neuronal population activity with high temporal resolution and cellular selectivity. Thus, when combined recordings ensemble in freely moving animals can provide an unprecedented snapshot contribution assemblies (patho)physiological conditions vivo. Still, combination optogenetic silicone probe (or tetrode) does not allow investigation role played by voltage- transmitter-gated channels opsin-transfected...
Neocortical interneurons provide inhibition responsible for organizing neuronal activity into brain oscillations that subserve cognitive functions such as memory, attention, or prediction. However, the interneuronal contribution to entrainment of neocortical within and across different cortical layers was not described. Here, using layer-specific optogenetic stimulations with micro-Light-Emitting Diode arrays, directed toward parvalbumin-expressing (PV) in non-anesthetized awake mice, we...
We prove that the L\"assig-Wiese (LW) field theory for freezing transition of secondary structure random RNA is renormalizable to all orders in perturbation theory. The proof relies on a formulation model terms walks and use multilocal operator product expansion. Renormalizability allows us work simpler scheme open polymers, obtain critical exponents at 2-loop order. It also some exact exponent identities, conjectured by LW.