A5042568278- Regulation of Appetite and Obesity
- Neuroinflammation and Neurodegeneration Mechanisms
- Diet and metabolism studies
- S100 Proteins and Annexins
- Biochemical Analysis and Sensing Techniques
- Neurological Disease Mechanisms and Treatments
- Lipid Membrane Structure and Behavior
- Neuroscience and Neuropharmacology Research
- Barrier Structure and Function Studies
- Photoreceptor and optogenetics research
Universidade do Porto
2024
HUN-REN Institute of Experimental Medicine
2022
Semmelweis University
2022
HUN-REN Szegedi Biológiai Kutatóközpont
2017-2019
Institute of Biophysics
2017-2019
Hungarian Academy of Sciences
2017-2019
Microglia, the main immunocompetent cells of brain, regulate neuronal function, but their contribution to cerebral blood flow (CBF) regulation has remained elusive. Here, we identify microglia as important modulators CBF both under physiological conditions and during hypoperfusion. Microglia establish direct, dynamic purinergic contacts with in neurovascular unit that shape mice humans. Surprisingly, absence or blockade microglial P2Y12 receptor (P2Y12R) substantially impairs coupling mice,...
We compared the effects of two different high-caloric diets administered to 4-week-old rats for 12 weeks: a diet rich in sugar (30% sucrose) and cafeteria high-fat foods. focused on hippocampus, particularly gamma-aminobutyric acid (GABA)ergic system, including Ca2+-binding proteins parvalbumin (PV), calretinin (CR), calbindin (CB), neuropeptides somatostatin (SST) neuropeptide Y (NPY). also analyzed density cholinergic varicosities, brain-derived neurotrophic factor (BDNF), reelin (RELN),...