A5018248573- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Gastrointestinal disorders and treatments
- Neuroendocrine Tumor Research Advances
- Gastrointestinal Tumor Research and Treatment
- Liver Disease Diagnosis and Treatment
- Renal cell carcinoma treatment
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Gastric Cancer Management and Outcomes
- Neuropeptides and Animal Physiology
- Cancer Genomics and Diagnostics
- Neuroendocrine regulation and behavior
- Ion Channels and Receptors
- Bariatric Surgery and Outcomes
- Neuroscience of respiration and sleep
- IgG4-Related and Inflammatory Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal and GI Pathology
- Adenosine and Purinergic Signaling
- Receptor Mechanisms and Signaling
- Radiomics and Machine Learning in Medical Imaging
- Respiratory and Cough-Related Research
- Abdominal vascular conditions and treatments
- Intestinal Malrotation and Obstruction Disorders
University of Pecs
2014-2024
Introduction Acute pancreatitis (AP) is an inflammatory disease with no specific treatment. Mitochondrial injury followed by ATP depletion in both acinar and ductal cells a recently discovered early event its pathogenesis. Importantly, preclinical research has shown that intracellular delivery restores the physiological function of protects from cell injury, suggesting restoration energy levels pancreas therapeutically beneficial. Despite several high quality experimental observations this...
The dried flowers of Chamaemelum nobile (L.) All. have been used in traditional medicine for different conditions related to the spasm gastrointestinal system. However, there no experimental studies support smooth muscle relaxant effect this plant. aim our research was assess effects hydroethanolic extract Roman chamomile, its fractions, four flavonoids (apigenin, luteolin, hispidulin and eupafolin), essential oil on muscles. phytochemical compositions fractions were characterized quantified...
Chronic pancreatitis is an inflammatory disease associated with structural and functional damage to the pancreas, causing pain, maldigestion weight loss thus worsening quality of life.Our aim was find correlations from a multicentre database representing epidemiological traits, diagnosis treatment in Hungary. The Hungarian Pancreatic Study Group collected data prospectively 2012 2014 on patients suffering chronic pancreatitis. Statistical analysis performed different questions.Data 229 (74%...
Background & Aims: Pancreatic cancer is a devastating disease with poor prognosis. There very limited information available regarding the epidemiology and treatment strategies of pancreatic in Central Europe. The purpose study was to prospectively collect analyze data Hungarian population.
 Methods: Study Group (HPSG) organized prospective, uniform collection. Altogether 354 patients were enrolled from 14 centers.
 Results: Chronic pancreatitis present 3.7% cases, while 33.7%...
Objectives Serine protease inhibitor Kazal type 1 (SPINK1) provides an important line of defense against premature trypsinogen activation within the pancreas. Our aim was to identify pathogenic SPINK1 promoter variants associated with chronic pancreatitis (CP). Methods One hundred CP patients (cases) and 100 controls no pancreatic disease from Hungarian National Pancreas Registry were enrolled. Direct sequencing region performed. Functional characterization carried out using luciferase...
Background: The aim of study was to compare the results different surgical modalities/mesh (onlay/sublay position) and suture repair in treatment abdominal hernias. Methods: According size hernia gate patients were divided into two groups: small hernias (hernia between 5-25 cm2) large (gate > 25 cm2). In these groups randomized according procedure: group ‘A’ vs. mesh ‘B’ onlay sublay reconstruction. Results: n = 734. significantly higher recurrences occurred after than (27.2% 8.3% – p <...
Although 21 pancreatic cancer susceptibility loci have been identified in individuals of European ancestry through genome-wide association studies (GWASs), much the heritability risk remains unidentified. A recessive genetic model could be a powerful tool for identifying additional variants. To discover recessively inherited loci, we performed re-analysis largest GWAS, Pancreatic Cancer Cohort Consortium (PanScan) and Case-Control (PanC4), including 8,769 cases 7,055 controls ancestry. Six...
<i>Background/Aims:</i> Recently organ-saving procedures have become popular in the treatment of chronic pancreatitis with head enlargement. The purpose this study is to compare results three different procedures. <i>Methods:</i> Between 1991 and 1998, 32 Beger operations, 13 Frey 21 pylorus-preserving pancreatoduodenectomies (PPPDs) were performed. pre-, intra- postoperative data detailed. During follow-up examination quality life, body weight, consumption alcohol...
Pancreatic carcinoma is one of the most malignant diseases and associated with a poor survival rate. Pituitary adenylate cyclase activating polypeptide (PACAP) neuropeptide that acts on three different G protein‑coupled receptors: specific PAC1 VPAC1/2 also bind vasoactive intestinal peptide. PACAP widely distributed in body has diverse physiological effects. Among other things, it as trophic factor influences proliferation differentiation several cells both under normal circumstances...
The contractile effect of AITC (300 μM) on human jejunal longitudinal strips was inhibited by the TRPA1 antagonist HC 030031 and atropine or scopolamine, but insensitive to tetrodotoxin, purinoceptor antagonists capsaicin desensitization. It is concluded that activation stimulates a cholinergic mechanism in tetrodotoxin-resistant manner.
Background Acute pancreatitis (AP) is an inflammatory condition that can lead to late consequences. Recurrent AP (RAP) develops in 20% of patients and chronic (CP) occurs 7%–12.8%. However, we do not have sufficient information establish evidence-based statement define early CP, or how prevent its development. Aim The aim this study was understand the influencing factors determine which parameters should be measured used as a biomarker detect phase CP. Methods/Design This observational...
In spite of the increase in radicality and extended resections, prognosis gastric cancer is very poor. Surgical resection only effective therapy. The morbidity mortality surgical interventions decreased during last years.The aim this study was to evaluate prognostic effect different factors on survival cancer. A retrospective 483 patients with performed. Data were collected from January 1993 December 2002. There 380 267 (70,2%) total gastrectomies, 93 (24.8%) distal resections 20 (5.2%)...