A5084421962- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Immune Response and Inflammation
- CAR-T cell therapy research
- Immunodeficiency and Autoimmune Disorders
- RNA and protein synthesis mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Animal Virus Infections Studies
- Pancreatic function and diabetes
- Cancer Immunotherapy and Biomarkers
- Cytomegalovirus and herpesvirus research
- Cell Adhesion Molecules Research
- Virus-based gene therapy research
- Herpesvirus Infections and Treatments
- Influenza Virus Research Studies
- Celiac Disease Research and Management
- Mycobacterium research and diagnosis
- Toxoplasma gondii Research Studies
- RNA Interference and Gene Delivery
- Tuberculosis Research and Epidemiology
- Respiratory viral infections research
- Dermatology and Skin Diseases
- Bacteriophages and microbial interactions
Stanford University
2014-2024
Stratford University
2018-2022
Bipar
2002-2013
Institute of Infection and Immunity
2013
Stanford Medicine
2009
Institut Pasteur
2005
Howard Hughes Medical Institute
1993-2002
Eos Neuroscience (United States)
2001
Paul Ehrlich Institut
1998
National Yang Ming Chiao Tung University
1998
Hematopoietic stem cells (HSCs) isolated from mouse fetal liver, like adult HSCs, are Thy-1lo Lin- Sca-1+. Donor-derived V gamma 3+ T were detected in thymic lobes repopulated vitro with liver but not those bone marrow HSCs. Single clonogenic HSCs gave rise to progeny that include 3+, other delta+, and alpha beta+ cells. No thymus injected intrathymically either or These results support the hypothesis only have capacity differentiate into microenvironment developmental potential of may...
T lymphocyte activation is mediated by the interaction of specific TCR with antigenic peptides bound to MHC molecules. Single amino acid substitutions are often capable changing effect a peptide from stimulatory antagonistic. Using surface plasmon resonance, we have analyzed between complex consisting variants MCC mouse class II (Ek) and TCR. both an improved direct binding method as well novel inhibition assay, show that affinities three different antagonist peptide–Ek complexes ∼10–50...
In this work, we find that CD8
Abstract The ideal vaccine against viruses such as influenza and SARS-CoV-2 must provide a robust, durable broad immune protection multiple viral variants. However, antibody responses to current vaccines often lack robust cross-reactivity. Here we describe polymeric Toll-like receptor 7 agonist nanoparticle (TLR7-NP) adjuvant, which enhances lymph node targeting, leads persistent activation of cells responses. When mixed with alum-adsorbed antigens, this TLR7-NP adjuvant elicits...
γδ T cell receptors (TCRs), αβ TCRs, and antibodies are the three lineages of somatically recombined antigen receptors. The structural basis for ligand recognition is well defined TCR but lacking TCRs. We present 3.4 Å structure murine G8 bound to its major histocompatibility complex (MHC) class Ib ligand, T22. predominantly uses germline-encoded residues δ chain complementarity-determining region 3 (CDR3) loop bind T22 in an orientation substantially different from that seen...
Celiac disease is an intestinal autoimmune driven by dietary gluten and gluten-specific CD4 + T-cell responses. In celiac patients on a gluten-free diet, exposure to induces the appearance of T cells with gut-homing potential in peripheral blood. Here we show that also activated, CD8 αβ γδ Single-cell receptor sequence analysis indicates both these cell populations have highly focused repertoires, indicating their induction antigen-driven. These results reveal previously unappreciated role...
The molecular basis of gammadelta T cell receptor (TCR) recognition is poorly understood. Here, we analyze the TCR sequences a natural population specific for major histocompatibility complex class Ib molecule T22. We find that T22 correlates strongly with somatically recombined TCRdelta complementarity-determining region 3 (CDR3) motif derived from germ line-encoded residues. Sequence diversity around these residues modulates ligand-binding affinities, whereas V gene usage mainly tissue...
Several 50 to 70S tumor viral RNAs have previously been shown by electron microscopy be dimers, with the two monomer subunits joined near their 5' ends. Five additional naturally occurring type C RNA viruses now examined: AKR, and endogenous murine ecotropic virus; NZB, an xenotropic amphotropic virus isolated from a wild mouse; avian reticuloendotheliosis (REV). All five similar 5'-to-5' dimer structures. Therefore, observations support hypothesis that linkage is structural feature common...
Host-adapted strains of Salmonella enterica cause systemic infections and have the ability to persist systemically for long periods time despite presence a robust immune response. Chronically infected hosts are asymptomatic transmit disease naïve via fecal shedding bacteria, thereby serving as critical reservoir disease. We show that bacterial effector protein SseI (also called SrfH), which is translocated into host cells by Pathogenicity Island 2 (SPI2) type III secretion system (T3SS),...