A5015223159- Diabetes Management and Research
- Protein Kinase Regulation and GTPase Signaling
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes and associated disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Metabolism, Diabetes, and Cancer
- Wnt/β-catenin signaling in development and cancer
- Diet and metabolism studies
- Pancreatic function and diabetes
- Hippo pathway signaling and YAP/TAZ
- Melanoma and MAPK Pathways
- Diabetes Treatment and Management
- Cellular transport and secretion
- Cellular Mechanics and Interactions
- Cell Adhesion Molecules Research
- Microtubule and mitosis dynamics
- Gestational Diabetes Research and Management
- Hemoglobinopathies and Related Disorders
- Protein Structure and Dynamics
- Estrogen and related hormone effects
- Enzyme Structure and Function
- Acute Myocardial Infarction Research
- Receptor Mechanisms and Signaling
- Cardiovascular Function and Risk Factors
- Erythrocyte Function and Pathophysiology
National Institutes of Health
2016-2025
National Institute of Allergy and Infectious Diseases
2021-2025
National Institutes of Health Clinical Center
2015-2024
National University of Singapore
2024
University of Kigali
2023
Georgetown University
2023
George Washington University
2023
University of Cape Town
2023
Reading Hospital
1988-2022
Johns Hopkins University
2014-2017
Multiple laboratory tests are used in the diagnosis and management of patients with diabetes mellitus. The quality scientific evidence supporting use these assays varies substantially.An expert committee drafted evidence-based recommendations for analysis diabetes. An external panel experts reviewed a draft guidelines, which were modified response to reviewers' suggestions. A revised was posted on Internet presented at AACC Annual Meeting July, 2000. again oral written comments. guidelines...
Abstract Background: Multiple laboratory tests are used in the diagnosis and management of patients with diabetes mellitus. The quality scientific evidence supporting use these assays varies substantially. Approach: An expert committee drafted evidence-based recommendations for analysis diabetes. external panel experts reviewed a draft guidelines, which were modified response to reviewers’ suggestions. A revised was posted on Internet presented at AACC Annual Meeting July, 2000. again oral...
The endothelial nitric-oxide synthase (eNOS) is a key determinant of vascular homeostasis. Like all known synthases, eNOS enzyme activity dependent on Ca<sup>2+</sup>-calmodulin. dynamically targeted to specialized cell surface signal-transducing domains termed plasmalemmal caveolae and interacts with caveolin, an integral membrane protein that comprises structural component caveolae. We have previously reported the association between caveolin quantitative tissue-specific (Feron, O.,...
While A1C is well established as an important risk marker for diabetes complications, with the increasing use of continuous glucose monitoring (CGM) to help facilitate safe and effective management, it understand how CGM metrics, such mean glucose, correlate. Estimated (eA1C) a measure converting from or self-monitored blood readings, using formula derived readings population individuals, into estimate simultaneously measured laboratory A1C. Many patients clinicians find eA1C be helpful...
Abstract Background: Glycohemoglobin (gHb), measured as hemoglobin (Hb) A1c or total gHb, provides a common means for assessing long-term glycemic control in individuals with diabetes mellitus. Genetic variants and chemically modified derivatives of Hb can profoundly affect the accuracy these measurements, although effects vary considerably among commercially available methods. The prevalence genetic such HbS, HbC, HbE, carbamyl-Hb patient populations undergoing testing is not insignificant....
Trends in the prevalence and control of diabetes defined by hemoglobin A1c (HbA1c) levels are important for health care policy planning.
Background Biochemical markers have not been routinely used in children at risk for myocardial damage. Yet, because of somatic growth and the duration survival, a low level damage may ultimately be more consequence than adults. Methods Results We investigated utility cardiac troponin T (cTnT) blood levels (CARDIAC ELISA Troponin T, Boehringer Mannheim Corp) 51 consecutively sampled patients from 1 day to 34 years age (median=5.7 years) undergoing cardiovascular (n=19) or noncardiovascular...
Nuclear factor of activated T cells (NFAT) proteins are Ca 2+ -regulated transcription factors that control gene expression in many cell types. NFAT heavily phosphorylated and reside the cytoplasm resting cells; when stimulated by a rise intracellular , dephosphorylated / calmodulin -dependent phosphatase calcineurin translocate to nucleus activate target expression. Here we show NFAT1 is present large cytoplasmic RNA-protein scaffold complex contains long intergenic noncoding RNA (lincRNA),...
Blood oligosaccharides are attached to many proteins after translation, forming glycoproteins. Glycosylation refers an enzyme-mediated modification that alters protein function, for example, their life span or interactions with other (1). By contrast, glycation a monosaccharide (usually glucose) attaching nonenzymatically the amino group of protein. Glycated hemoglobin is formed by condensation glucose select acid residues, commonly lysine, in form unstable Schiff base (aldimine, pre-HbA1c)...
Abstract Background Numerous laboratory tests are used in the diagnosis and management of diabetes mellitus. The quality scientific evidence supporting use these assays varies substantially. Approach An expert committee compiled evidence-based recommendations for analysis screening, diagnosis, or monitoring diabetes. overall strength were evaluated. draft consensus evaluated by invited reviewers presented public comment. Suggestions incorporated as deemed appropriate authors (see...
IQGAP1 modulates many cellular functions such as cell-cell adhesion, transcription, cytoskeletal architecture, and selected signaling pathways.We previously documented that binds extracellular signalregulated kinase (ERK) 2 regulates growth factor-stimulated ERK activity.Here we show MEK, the molecule immediately upstream of in Ras/mitogen-activated protein (MAP) cascade, also interacts directly with IQGAP1.Both MEK1 MEK2 bound vitro coimmunoprecipitated IQGAP1.The addition ERK2 enhanced by...
IQGAP1 is a scaffolding protein involved in multiple fundamental cellular activities, including transcription, cell-cell attachment, and regulation of the cytoskeleton. To function these pathways, associates with numerous proteins such as actin, calmodulin, E-cadherin, β-catenin, CLIP-170, components mitogen-activated kinase pathway. Moreover, binds to active Cdc42 Rac1 but not RhoA or Ras. Here we show that also small GTPase Rap1. In vitro analysis demonstrates direct interaction between...