A5015035858- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Risk Factors
- Diabetes Management and Research
- Liver Disease Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Diabetes Treatment and Management
- HIV-related health complications and treatments
- Obesity, Physical Activity, Diet
- Nutritional Studies and Diet
- Blood Pressure and Hypertension Studies
- Diet, Metabolism, and Disease
- Global Cancer Incidence and Screening
- Health disparities and outcomes
- Smoking Behavior and Cessation
- Frailty in Older Adults
- Systemic Lupus Erythematosus Research
- Economic and Financial Impacts of Cancer
- Birth, Development, and Health
- Diet and metabolism studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Dementia and Cognitive Impairment Research
- Chronic Kidney Disease and Diabetes
- Health Systems, Economic Evaluations, Quality of Life
- Multiple Myeloma Research and Treatments
- Cancer Treatment and Pharmacology
Connecting to Care
2022-2024
The Mountain Institute
2024
Flatiron Health (United States)
2018-2023
Christ University
2014-2019
Albert Einstein College of Medicine
2011-2017
Johns Hopkins University
2013-2016
Bloomberg (United States)
2014-2015
University of Baltimore
2015
National Institutes of Health
2012-2014
University of Miami
2014
Trends in the prevalence and control of diabetes defined by hemoglobin A1c (HbA1c) levels are important for health care policy planning.
We expanded the previous assessment of a mortality variable suited for real-world evidence-focused oncology research.We used nationwide electronic health record (EHR)-derived de-identified database.We included patients with at least 1 18 cancer types between January 1, 2011 and December 31, 2017. Patient-level structured data (EHRs, obituaries, Social Security Death Index) unstructured EHR (abstracted) were linked to generate composite variable.We benchmarked sensitivity, specificity,...
Individually, cardiac, renal, and metabolic (CRM) conditions are common leading causes of death, disability, health care-associated costs. However, the frequency with which CRM coexist has not been comprehensively characterized to date.
Background. Cytomegalovirus (CMV) infection has been implicated in immune activation and accelerated progression of immunodeficiency from human virus (HIV) coinfection. We hypothesized that CMV is associated with vascular disease HIV-infected adults. Methods. In the Women's Interagency HIV Study, we studied 601 90 HIV-uninfected participants. assessed association immunoglobulin G (IgG) level carotid artery intima-media thickness, distensibility, Young's elastic modulus, blood pressures....
Equivalence of laboratory tests over time is important for longitudinal studies. Even a small systematic difference (bias) can result in substantial misclassification.We selected 200 Atherosclerosis Risk Communities Study participants attending all 5 study visits 25 years. Eight analytes were remeasured 2011-2013 from stored blood samples multiple visits: creatinine, uric acid, glucose, total cholesterol, HDL LDL triglycerides, and high-sensitivity C-reactive protein. Original values...
There is growing interest in leveraging real-world data to complement knowledge gained from randomized clinical trials and inform the design of prospective studies oncology. The present study compared outcomes women with metastatic breast cancer who received letrozole as first-line monotherapy oncology practices across United States versus patients letrozole-alone cohort PALOMA-2 phase 3 trial. (N = 107) was derived de-identified patient Flatiron Health electronic health record database....
Background: Inflammation and hemostasis perturbation may be involved in vascular complications of HIV infection. We examined atherogenic biomarkers subclinical atherosclerosis HIV-infected adults before after beginning highly active antiretroviral therapy (HAART). Methods: In the Women's Interagency Study, 127 women studied pre post HAART were matched to HIV-uninfected controls. Six semiannual measurements soluble CD14, tumor necrosis factor (TNF) alfa, interleukin (IL) 2 receptor, IL-6,...
Background All major Hispanic/Latino groups in the United States have a high prevalence of obesity, which is often severe. Little known about cardiovascular disease ( CVD ) risk factors among those at very levels body mass index BMI ). Methods and Results Among US Hispanic men (N=6547) women (N=9797), we described gradients across range age including hypertension, serum lipids, diabetes, C‐reactive protein. Sex differences factor prevalences were determined each level , after adjustment for...
OBJECTIVE Controversy surrounds appropriate risk factor targets in older adults with diabetes. We evaluated the proportion of diabetes meeting different targets, focusing on possible differences by race, and assessed whether demographic clinical characteristics explained disparities. RESEARCH DESIGN AND METHODS conducted a cross-sectional study 5,018 participants aged 67–90 years (1,574 3,444 without diagnosed diabetes) who attended visit 5 Atherosclerosis Risk Communities (ARIC)...
The use of digital symptom monitoring with patient-reported outcomes (PROs) has been shown to improve patient outcomes. evidence benefit largely derived from research studies. feasibility adopting this technology in the real-world setting is unknown.We report on clinical implementation a proprietary electronic outcome (ePRO)-based platform at Highlands Oncology Group practice, large community oncology practice. We present here our experience enrollment, engagement, and retention; reasons for...
Abstract Background There is a need for continued surveillance of diabetes‐related functional disability. In the present study, we examined associations between diabetes, hyperglycemia, and burden disability in community‐based population. Methods A cross‐sectional analysis was conducted 5035 participants who attended Visit 5 (2011–13) Atherosclerosis Risk Communities study. Functional dichotomously defined by any self‐reported difficulty performing 12 tasks essential to independent living...
Background Adults infected with HIV have increased atherosclerosis potentially associated both and non‐ factors. We characterized risk factors for as measured by noninvasive vascular imaging. Methods Results used B‐mode ultrasound to examine levels correlates of echogenicity vessel wall thickness the carotid artery intima‐media complex in 1282 ‐infected 510 ‐uninfected women Women's Interagency Study. Levels gray scale median ( GSM , a measure echogenicity) did not vary between infection...
OBJECTIVE We compared levels and associations of traditional (fasting glucose, HbA1c) nontraditional (fructosamine, glycated albumin, 1,5-anhydroglucitol [1,5-AG]) biomarkers hyperglycemia with incident cardiovascular disease (CVD), end-stage renal (ESRD), prevalent retinopathy in black white adults. RESEARCH DESIGN AND METHODS included 10,373 participants without (8,096 white, 2,277 black) 727 diagnosed diabetes (425 302 from the Atherosclerosis Risk Communities (ARIC) Study. used Cox...
Extreme values that arise for any reason, including those through nonlaboratory measurement procedure-related processes (inadequate mixing, evaporation, mislabeling), lead to outliers and inflate errors in recalibration studies. We present an approach termed iterative outlier removal (IOR) identifying such outliers.We previously identified substantial laboratory drift uric acid measurements the Atherosclerosis Risk Communities (ARIC) Study over time. Serum was originally measured 1990-1992...
Introduction: Nonalcoholic fatty liver disease (NAFLD) is believed to be the most common chronic worldwide. Therapies are under development for nonalcoholic steatohepatitis (NASH), progressive form of NAFLD, such that prevalence NASH with fibrosis, which likely require treatment, may interest healthcare decision makers. Noninvasive tests used in initial screening NASH, as well observational studies prevalence. However, existing evidence does not address how estimated varies different...
Nonalcoholic fatty liver disease (NAFLD) is believed to be the most common chronic worldwide. Therapies are under development for nonalcoholic steatohepatitis (NASH), progressive form of NAFLD, such that prevalence NASH with fibrosis, which likely require treatment, may interest healthcare decision makers. Noninvasive tests used in initial screening NASH, as well observational studies prevalence. However, existing evidence does not address how estimated varies different noninvasive tests....