A5078768064- Advanced Breast Cancer Therapies
- Immune cells in cancer
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Cell Adhesion Molecules Research
- EFL/ESL Teaching and Learning
- Virus-based gene therapy research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Viral Infectious Diseases and Gene Expression in Insects
- Breast Cancer Treatment Studies
- Sarcoma Diagnosis and Treatment
- Second Language Learning and Teaching
- Protease and Inhibitor Mechanisms
- Biological Stains and Phytochemicals
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Male Breast Health Studies
- HER2/EGFR in Cancer Research
- Innovations in Education and Learning Technologies
- Student Assessment and Feedback
- Tryptophan and brain disorders
- Philosophy and History of Science
- Cancer Research and Treatments
- Animal Virus Infections Studies
Pfizer (United States)
2018-2025
Moffitt Cancer Center
2009-2023
Hokusei Gakuen University
2019
Flatiron Health (United States)
2018
RTI Health Solutions
2018
Sidney Kimmel Comprehensive Cancer Center
2018
University of Pittsburgh Medical Center
2018
AdventHealth Tampa
2010
Reata Pharmaceuticals (United States)
2010
Texas Oncology
2010
Myeloid-derived suppressor cells (MDSCs) are a major component of the immune-suppressive network described in cancer and many other pathological conditions. We demonstrate that although MDSCs from peripheral lymphoid organs tumor site share similar phenotype morphology, these display profound functional differences. MDSC suppressed antigen-specific CD8+ T but failed to inhibit nonspecific cell function. In sharp contrast, both activity. The microenvironment caused rapid dramatic...
Myeloid-derived suppressor cells (MDSC) are a major component of the immune suppressive network described in cancer and many other pathological conditions. Recent studies have demonstrated that one mechanisms MDSC-induced suppression is mediated by reactive oxygen species (ROS). However, mechanism this phenomenon remained unknown. In study, we observed substantial up-regulation ROS MDSC all seven different tumor models patients with head neck cancer. The increased production up-regulated...
Myeloid-derived suppressor cells (MDSC) are one of the major factors responsible for immune suppression in cancer. Therefore, it would be important to identify effective therapeutic means modulate these cells.We evaluated effect synthetic triterpenoid C-28 methyl ester 2-cyano-3,12-dioxooleana-1,9,-dien-28-oic acid (CDDO-Me; bardoxolone methyl) MC38 colon carcinoma, Lewis lung and EL-4 thymoma mouse tumor models, as well blood samples from patients with renal cell cancer soft tissue sarcoma....
Helper-dependent adenovirus (HD-Ad) vectors with all adenoviral genes deleted mediate very long-term expression of therapeutic transgenes in a variety animal models disease. These are associated reduced toxicity and improved safety relative to traditional early region 1 deletion first-generation Ad (FG-Ad) vectors. Many studies have clearly demonstrated that FG-Ad induce innate adaptive immune responses vivo; however, comprehensive analysis host HD-Ad has not yet been performed. In DBA/2...
ABSTRACT Adeno-associated virus (AAV) vectors are associated with relatively mild host immune responses in vivo. Although AAV induces very weak innate responses, neutralizing antibodies against the vector capsid and transgene still occur. To understand further basis of antiviral response to vectors, studies were performed characterize interactions macrophages. Primary mouse macrophages human THP-1 cells transduced vitro using an serotype 2 (AAV2) encoding green fluorescent protein did not...
There is growing interest in leveraging real-world data to complement knowledge gained from randomized clinical trials and inform the design of prospective studies oncology. The present study compared outcomes women with metastatic breast cancer who received letrozole as first-line monotherapy oncology practices across United States versus patients letrozole-alone cohort PALOMA-2 phase 3 trial. (N = 107) was derived de-identified patient Flatiron Health electronic health record database....
This report examined the benefits and risks of palbociclib plus endocrine therapy (ET) in men with hormone receptor‒positive (HR+)/human epidermal growth factor receptor 2−negative (HER2−) metastatic breast cancer (MBC). Palbociclib was evaluated using three independent data sources: real‐world from pharmacy medical claims, a de‐identified source derived electronic health records (EHRs), global safety database. From records, 1,139 MBC were identified; first‐line setting, median duration...
ABSTRACT Neutrophils are effectors of the innate immune response to adenovirus vectors. Following systemic administration Cy2-labeled AdLuc in mice, flow cytometry and PCR analysis liver leukocytes revealed that 25% recruited neutrophils interacted with In vitro, human incubated also demonstrated a significant interaction Fluorescence electron microscopy confirmed vector internalization by neutrophils. The AdLuc-neutrophil reduced transduction efficiency more than 50% coincubation assays...
Abstract Adenovirus is a nonenveloped dsDNA virus that activates intracellular innate immune pathways. In vivo, adenovirus-immunized mice displayed an enhanced response and diminished virus-mediated gene delivery following challenge with the adenovirus vector AdLacZ suggesting antiviral Abs modulate viral interactions cells. Under naive serum conditions in vitro, binding internalization macrophages subsequent activation of mechanisms were inefficient. contrast to neutralizing effect observed...
Despite several randomized controlled trials demonstrating the benefits of combination therapies for metastatic hormone-sensitive prostate cancer (mHSPC), a significant treatment gap persists. This initiative by Prostate Cancer Foundation (PCF) convened stakeholders from academia, community practices, industry, and patient advocacy groups to address critical challenges in mHSPC care. Expert discussions review real-world evidence meta-analyses informed development strategies improve care...
Abstract Ly-6G is a member of the Ly-6 family GPI-linked proteins, which expressed on murine neutrophils. Antibodies against cause neutropenia, and fatal reactions also develop if mice are primed with TNF-α prior to antibody treatment. We have investigated mechanisms behind these responses ligation in belief that similar may be involved neutropenia respiratory disorders associated alloantibody related member, NB1, humans. Neutrophil adhesion, microvascular obstruction, breathing...
During this investigation, a model of tourniquet-induced forearm ischaemia-reperfusion injury is employed to investigate the role leucocytes in damage vascular endothelium during injury. Leucocyte entrapment investigated by measuring concentration venous blood leaving arm. Neutrophil and monocyte leucocyte subpopulations are isolated density gradient centrifugation techniques. Cell surface expression CD11b intracellular production hydrogen peroxide measured via flow cytometry. Plasma...
1055 Background: The rarity of BC in men limits the feasibility randomized clinical studies this population. Treatment guidelines recommend that with be treated similarly to postmenopausal women. PAL, a cyclin-dependent kinase 4/6 inhibitor, is used metastatic (mBC) real-world practice, presenting an opportunity utilize evidence enable healthcare providers assess novel agents space. Methods: Two parallel approaches were taken. In first approach, pharmacy and medical claims data from IQVIA...
The key to successful cancer immunotherapy is induce an effective anticancer immunity that will overcome the acquired cancer-specific immune tolerance. In this study, we found dendritic cells (DCs) from multiple myeloma (MM) patients suppressed rather than induced a cell-specific response. We demonstrated CD4+CD25high T MM proliferation of activated peripheral blood lymphocytes. Further analysis illustrated cell lysates or MM-specific idiotype immunoglobulins (MM Id-Ig) specifically...
PurposeTo evaluate treatment patterns and clinical outcomes of patients who received palbociclib in combination with letrozole any line therapy for hormone receptor–positive, human epidermal growth factor receptor 2–negative metastatic breast cancer an expanded access program (EAP) the United States.Patients MethodsA retrospective chart review study was conducted previously enrolled EAP. Complete data from time initial diagnosis until date abstraction were obtained. Clinical as assessed by...
Abstract Background: There is growing interest to assess treatment effect with clinical endpoints that are reflective of real world practice based on data systemically collected from the electronic health record (EHR). This study compared PFS (rwPFS) among a cohort female patients (pts) treated letrozole (LET) monotherapy as first-line therapy for metastatic breast cancer (MBC) in routine using RECIST criteria LET alone randomized trial (PALOMA-2). Methods: For rwPFS, assessments were...
The objective of this study was to establish the maximum tolerated dose (MTD), safety, pharmacokinetics, and anti-leukemic activity talazoparib.This Phase I, two-cohort, dose-escalation trial evaluated talazoparib monotherapy in advanced hematologic malignancies (cohort 1: acute myeloid leukemia/myelodysplastic syndrome; cohort 2: chronic lymphocytic leukemia/mantle cell lymphoma).Thirty-three n = 25; 8) patients received (0.1-2.0 mg once daily). MTD exceeded at 2.0 mg/day 1 0.9 2. Grade ≥3...