A5002699935- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Polyomavirus and related diseases
- Cancer Genomics and Diagnostics
- Advanced Breast Cancer Therapies
- Arsenic contamination and mitigation
- Heavy Metal Exposure and Toxicity
- Nonmelanoma Skin Cancer Studies
- Full-Duplex Wireless Communications
- Antenna Design and Analysis
- Global Cancer Incidence and Screening
- Lung Cancer Diagnosis and Treatment
- Plant Virus Research Studies
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Research Studies
- Cancer-related Molecular Pathways
- Child Nutrition and Water Access
- Pregnancy and Medication Impact
- Cardiovascular Health and Risk Factors
- Genetic factors in colorectal cancer
- Male Breast Health Studies
- Single-cell and spatial transcriptomics
- Genetic Associations and Epidemiology
- Health Systems, Economic Evaluations, Quality of Life
- Plant Pathogens and Fungal Diseases
Flatiron Health (United States)
2017-2023
Dartmouth College
2015-2018
Dartmouth Hospital
2015
Quantitative BioSciences
2014
<h3>Importance</h3> Data sets linking comprehensive genomic profiling (CGP) to clinical outcomes may accelerate precision medicine. <h3>Objective</h3> To assess whether a database that combines EHR-derived data with CGP can identify and extend associations in non–small cell lung cancer (NSCLC). <h3>Design, Setting, Participants</h3> Clinical from EHRs were linked results for 28 998 patients 275 US oncology practices. Among 4064 NSCLC, exploratory between tumor genomics patient...
We expanded the previous assessment of a mortality variable suited for real-world evidence-focused oncology research.We used nationwide electronic health record (EHR)-derived de-identified database.We included patients with at least 1 18 cancer types between January 1, 2011 and December 31, 2017. Patient-level structured data (EHRs, obituaries, Social Security Death Index) unstructured EHR (abstracted) were linked to generate composite variable.We benchmarked sensitivity, specificity,...
Polyomaviruses (PyV) are potentially tumorigenic in humans. However, limited data exist on the population seroprevalence of PyVs and individual characteristics that relate to seropositivity. Using multiplex serology, we determined 10 human (BK, JC, KI, WU, MCV, HPyV6, HPyV7, TSV, HPyV9, HPyV10) among controls from a population-based skin cancer case-control study (n = 460) conducted New Hampshire between 1993 1995. On subset participants 194), methylation at CpG dinucleotides across genome...
Despite the rapid adoption of immunotherapies in advanced non-small cell lung cancer (advNSCLC), knowledge gaps remain about their real-world (rw) performance.This retrospective, observational, multicenter analysis used Flatiron Health deidentified electronic health record-derived database rw patients with advNSCLC who received treatment PD-1 and/or PD-L1 (PD-[L]1) inhibitors before July 1, 2017 (N = 5257) and had ≥6 months follow-up. The authors investigated PD-(L)1 line testing rates...
Abstract Background Evidence from cancer clinical trials can be difficult to generalize real-world patient populations, but complemented by evidence optimize personalization of care. Further, usage patterns programmed cell death protein 1 (PD-1) inhibitors following approval inform future studies subpopulations underrepresented in trials. Materials and Methods We performed a multicenter analysis using electronic health record data collected during routine care patients treated community...
Evidence from cancer clinical trials has strong internal validity but can be difficult to generalize real-world patient populations. Here we analyzed outcomes of patients with metastatic non-small cell lung (mNSCLC) treated programmed death protein 1 (PD-1) inhibitors in the first year following U.S. regulatory approval.This retrospective study leveraged electronic health record (EHR) data collected during routine care community clinics. The cohort included mNSCLC who had received nivolumab...
Gestational diabetes mellitus (GDM) is a major pregnancy complication with detrimental effects for both mothers and their children. Accumulating evidence has suggested potential role arsenic (As) exposure in the development of GDM, but current studies have not assessed As from water, urine or toenail samples. We investigated association between risk glucose intolerance GDM among 1151 women enrolled New Hampshire Birth Cohort Study. Arsenic was measured home well water via biomarkers (i.e.,...
The aim of this study was to assess the impact missing death data on survival analyses conducted in an oncology EHR-derived database.The using Flatiron Health database and National Death Index (NDI) as a gold standard. Three analytic frameworks were evaluated advanced non-small cell lung cancer (aNSCLC) patients: median overall [mOS]), relative risk estimates within database, "external control arm" comparing experimental group augmented with mortality from standard only. hazard ratios (HRs)...
This report examined the benefits and risks of palbociclib plus endocrine therapy (ET) in men with hormone receptor‒positive (HR+)/human epidermal growth factor receptor 2−negative (HER2−) metastatic breast cancer (MBC). Palbociclib was evaluated using three independent data sources: real‐world from pharmacy medical claims, a de‐identified source derived electronic health records (EHRs), global safety database. From records, 1,139 MBC were identified; first‐line setting, median duration...
This retrospective observational study described baseline characteristics, real-world treatment patterns, and outcomes among patients with metastatic breast cancer treated abemaciclib in the United States.De-identified electronic health record-derived data were used to describe who began on or after 30 June 2016 ≥4 months before cutoff (31 December 2018). Real-world response (rwR) progression assessments abstracted from clinical documentation. Descriptive statistics calculate best response....
Men are at a higher risk of developing both squamous cell carcinoma (SCC) and basal (BCC) than women, but there is emerging evidence that women may be experiencing greater increases in the incidence rates these malignancies men. One possible explanation expanding use sex steroids among although only few studies have examined this hypothesis. As part population-based, case-control study New Hampshire, USA, we sought to evaluate SCC, BCC, early-onset BCC relation exogenous endogenous hormones....
Background: Rice contains arsenic, a known skin carcinogen. intake has been associated with arsenic-related lesions in South Asia, but its association cancers is as yet unknown. Objectives: We aimed to investigate whether rice contributes urinary arsenic concentration and risk of squamous cell carcinoma (SCC) the U.S. population. Methods: consumption was assessed using food frequency questionnaire administered part population-based case–control study 487 SCC cases 462 age- gender-matched...
Clinical trials suggest α-fetoprotein (AFP) reduction may be prognostic among patients with advanced hepatocellular carcinoma. However, the association of AFP outcomes in real-world settings is unclear.Patients carcinoma between January 1, 2011, and June 30, 2021, first-line tyrosine kinase inhibitor, baseline posttreatment values (closest to 8 ± 2 weeks after initiation) were included. was defined as ≥20% decrease from vs <20% or no decrease. Real-world overall survival progression-free...
2514 Background: Genomic findings have diagnostic, prognostic, and predictive utility in clinical oncology. Population studies been limited by reliance on trials, registries, or institutional chart review, which are costly represent narrow populations. Integrating electronic health record (EHR) genomic data collected as part of routine practice may overcome these hurdles. Methods: Patients the Flatiron Health Database with non-small cell lung cancer (NSCLC) who underwent comprehensive...
Abstract Background: Abemaciclib is a selective continually dosed cyclin-dependent kinase 4 and 6 (CDK 4&6) inhibitor approved as single agent in combination with endocrine therapy for the treatment of HR+,HER2- metastatic breast cancer (MBC). To date, few publications have reported real world (rw) use abemaciclib. This retrospective observational study aimed to describe baseline characteristics, patterns, outcomes among MBC patients treated abemaciclib US. Methods: who initiated on or...
Squamous cell carcinoma (SCC) of the skin is a malignancy arising from epithelial keratinocytes. Experimental and epidemiologic evidence raise possibility that human polyomaviruses (PyV) may be associated with occurrence SCC. To investigate whether risk for SCC was PyV infection, seropositivity to 10 types assessed following diagnosis in population-based case-control study conducted United States. A total 253 cases 460 age group gender-matched controls were included. Antibody response...
Abstract Background: Merkel cell polyomavirus (PyV) is causally related to carcinoma, a rare skin malignancy. Little known about the serostability of other PyVs over time or associations with cutaneous squamous carcinoma (SCC). Methods: As part U.S. nested case–control study, antibody response against PyV VP1 capsid proteins BK and John Cunningham virus (JC) was measured using multiplex serology on 113 SCC cases 229 gender, age, study center–matched controls who had prior keratinocyte...
2569 Background: ICIs (anti-PD-L1/PD-1/CTLA-4) are approved in multiple cancers. The impact of organ dys on the pharmacokinetics is known, but associated clinical outcomes not well characterized. We compared real-world (rw) ICI-treated pts by liver and renal function. Methods: This retrospective study used longitudinal, patient-level data from community practices Flatiron Health electronic-health record (EHR)-derived database. included diagnosed with advanced cancers (NSCLC, cell, melanoma,...