A5057132038- Renal Diseases and Glomerulopathies
- SARS-CoV-2 and COVID-19 Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Ion Transport and Channel Regulation
- Vasculitis and related conditions
- Autoimmune Bullous Skin Diseases
- Renal Transplantation Outcomes and Treatments
- Complement system in diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Animal Virus Infections Studies
- COVID-19 Clinical Research Studies
- Iron Metabolism and Disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
- Chronic Kidney Disease and Diabetes
- Cancer Treatment and Pharmacology
- Nephrotoxicity and Medicinal Plants
- Advanced Breast Cancer Therapies
- SARS-CoV-2 detection and testing
- Drug-Induced Adverse Reactions
- Electrolyte and hormonal disorders
- Immunodeficiency and Autoimmune Disorders
- Biomedical Research and Pathophysiology
- Renal and Vascular Pathologies
- Magnesium in Health and Disease
- Kidney Stones and Urolithiasis Treatments
Massachusetts General Hospital
2020-2025
Harvard University
2020-2025
Brigham and Women's Hospital
2020-2022
Saint Vincent Hospital
2019-2022
Emory University
2016
Hacettepe University Hospital
2015
Hacettepe University
2012
Long-term organ transplant survival remains suboptimal, and life-long immunosuppression predisposes recipients to an increased risk of infection, malignancy, kidney toxicity. Promoting the regulatory arm immune system by expanding Tregs may allow minimization improve long-term graft outcomes. While low-dose IL-2 treatment can expand Tregs, it has a short half-life off-target expansion NK effector T cells, limiting its clinical applicability. Here, we designed humanized mutein with high Treg...
Urine concentration is regulated by vasopressin. Congenital nephrogenic diabetes insipidus (NDI) caused vasopressin type 2 receptor (V2R) mutations. We studied whether metformin could improve urine in rodent models of congenital NDI stimulating AMPK. To block the V2R rats, tolvaptan (10 mg/kg/d) was given oral gavage with or without (800 mg/ kg/d). Control rats received vehicle metformin. Tamoxifen-induced KO mice were (600 mg/kg) twice daily. osmolality tolvaptan-treated (1,303 ± 126 mOsM)...
Introduction Studies have shown reduced antiviral responses in kidney transplant recipients (KTRs) following SARS-CoV-2 mRNA vaccination, but data on post-vaccination alloimmune and against the Delta (B.1.617.2) variant are limited. Materials methods To address this issue, we conducted a prospective, multi-center study of 58 adult KTRs receiving mRNA-BNT162b2 or mRNA-1273 vaccines. We used multiple complementary non-invasive biomarkers for rejection monitoring including serum creatinine,...
Membranous nephropathy (MN) is one of the most common causes nephrotic syndrome in adults. The discovery phospholipase A2 receptor (PLA2R) as a target antigen has led to paradigm shift understanding and management MN. At present, serum PLA2R antibodies are used for diagnosis, prognostication, guiding treatment. Now, with more than 20 novel antigens, mapping almost complete. clinical association certain antigens provides clues clinicians, such nerve epidermal growth factor-like 1 malignancies...
Ebrahimi, Niloufar; Ha, Vince; Whittier, William; Efe, Orhan; Kronbichler, Andreas; Grace Choung, Hae Yoon; Singh, Arvind; Abdipour, Amir; Norouzi, Sayna Author Information
Vasopressin triggers the phosphorylation and apical plasma membrane accumulation of aquaporin 2 (AQP2), it plays an essential role in urine concentration. Vasopressin, acting through protein kinase A, phosphorylates AQP2. However, state AQP2 could also be affected by action phosphatases (PPs). Rat inner medullas (IM) were incubated with calyculin (PP1 PP2A inhibitor, 50 nM) or tacrolimus (PP2B 100 nM). Calyculin did not affect total abundance (by Western blot) but significantly increase...
Our objective was to characterize the incidence, risk factors and clinical features of acute kidney injury (AKI) in patients receiving dabrafenib trametinib.We performed a retrospective cohort study examining outcomes large healthcare system who received dabrafenib/trametinib between 2010 2019. The primary outcome AKI, defined as 1.5-fold increase serum creatinine from baseline within 12-month period. AKI severity etiology determined for each case by chart review. Logistic regression used...
Thrombotic microangiopathies (TMAs) are life-threatening clinical syndromes due to dysregulation of the complement and coagulation cascades.1 When a precipitant endothelial injury persists (e.g., from infection, drug, autoimmunity, malignancy, or pregnancy), particularly in setting an acquired genetic defect and/or regulatory proteins, then alternative activity propagates abnormally without inhibition. Pathologically, this results microvascular thrombosis with predilection for glomeruli.
Abstract Background Available SARS-CoV-2 vaccines have reduced efficacy against the Omicron variant in immunocompetent individuals. Kidney transplant recipients (KTRs) diminished antiviral responses to wild-type after vaccination, and data on variants, including variant, are limited. Methods We conducted a prospective, multi-center cohort study of 51 adult KTRs who received three doses BNT162b2 or mRNA-1273. Blood urine samples were collected before four weeks third vaccine dose. The primary...
Aims and Background Capecitabine is a potent safe agent that can be used after anthracycline taxane treatment in patients with metastatic breast cancer (MBC). The purpose of this study was to investigate the efficacy safety capecitabine monotherapy as first-line human epidermal receptor 2 (HER2)-negative MBC. Methods Study design In single-center trial, total 109 HER2-negative MBC who received between 2003 2014 were retrospectively analyzed. Kaplan-Meier survival analysis carried out for...
Presentation of an interrupted aortic arch (IAA) in adulthood is extremely rare. Nonhemorrhagic stroke has not been reported previously any adult with IAA. We, herein, describe a formerly asymptomatic 52-year-old male presenting recurrent vertebrobasilar circulation ischemic strokes resulting from accelerated atherosclerotic arteriopathy secondary to IAA associated upper body hypertension. Surgical correction led treatment hypertension and cessation attacks together regression collateral...
Background Proteinuria is associated with worse allograft outcomes in kidney transplant recipients (KTRs) and treatment strategies are limited. We examined the of calcineurin inhibitor (CNI) to belatacept conversion proteinuric KTRs. Methods In a pilot phase II single-arm multicenter prospective trial, we recruited adult KTRs >6 months post-kidney transplantation an estimated glomerular filtration rate (eGFR) ≥30 ml/min/1.73m 2 proteinuria >1 g/day. Patients were converted from...
Key message: B cell-depleted patients carry a unique protracted COVID-19 risk, requiring strong suspicion and aggressive treatment. Dear Editor,Given the wide use of vaccinations, high prevalence prior SARS-CoV-2 infections, availability anti-virals, complications from have dropped dramatically.Although infections remain prevalent, they are increasingly ignored, or go unrecognized.Meanwhile, cell depletion with anti-CD20 monoclonal antibodies (rituximab others) has become standard treatment...
Essential thrombocytosis (ET) is usually an indolent disease but can uncommonly evolve into acute myeloid leukemia (AML) with a grim prognosis of 2-7 months. Studies report lower incidence leukemic transformation when compared to fibrotic transformation. The risk depends on the age, duration disease, and tumor biology. Hydroxyurea, cytoreductive agent, generally associated minimal adverse reactions; however, there are conflicting data its effect leukogenecity. We describe rare case...