A5050542258- Immune Cell Function and Interaction
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- CAR-T cell therapy research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- T-cell and B-cell Immunology
- Dermatology and Skin Diseases
- Bone Tumor Diagnosis and Treatments
- Glycosylation and Glycoproteins Research
- SARS-CoV-2 detection and testing
- Advancements in Transdermal Drug Delivery
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Animal Virus Infections Studies
- Ubiquitin and proteasome pathways
- Hair Growth and Disorders
- Multiple Myeloma Research and Treatments
Harvard University
2022-2024
Woman's Hospital
2024
Brigham and Women's Hospital
2022-2023
Disorders in the regulatory arm of adaptive immune system result autoimmune-mediated diseases. While systemic immunosuppression is prevailing approach to manage them, it fails achieve long-lasting remission due concomitant suppression and carries risk heightened susceptibility infections malignancies. Alopecia areata a condition characterized by localized hair loss autoimmunity. The accessibility skin allows local rather than intervention avoid broad immunosuppression. It hypothesized that...
Regulatory T cells (T regs ) have shown great promise as a means of cellular therapy in multitude allo- and auto-immune diseases—due part to their immunosuppressive potency. Nevertheless, the clinical efficacy human patients has been limited by poor vivo homeostasis. To avert apoptosis, require stable antigenic (CD3ζ/T-cell-receptor-mediated), co-stimulatory (CD28-driven), cytokine (IL-2-dependent) signaling. Notably, this sequence signals supports an activated reg phenotype that includes...
Abstract Background Available SARS-CoV-2 vaccines have reduced efficacy against the Omicron variant in immunocompetent individuals. Kidney transplant recipients (KTRs) diminished antiviral responses to wild-type after vaccination, and data on variants, including variant, are limited. Methods We conducted a prospective, multi-center cohort study of 51 adult KTRs who received three doses BNT162b2 or mRNA-1273. Blood urine samples were collected before four weeks third vaccine dose. The primary...
Although most CD8+ T cells are equipped to kill infected or transformed cells, a subset may regulate immune responses and preserve self-tolerance. Here, we describe CD8 lineage that is instructed differentiate into regulatory (Tregs) by surprisingly restricted set of cell receptors (TCRs) recognize MHC-E (mouse Qa-1) several dominant self-peptides. Recognition elimination pathogenic target express these Qa-1-self-peptide complexes selectively inhibits antibody without generalized...
We describe our discovery and development of potent highly selective inhibitors human constitutive proteasome chymotryptic activity (β5c). Structure–activity relationship studies the novel class focused on optimization N-cap, C-cap, side chain chemophore asparagine. Compound 32 is most β5c inhibitor in this study. A docking study provides a structure rationale for potency selectivity. Kinetic show reversible noncompetitive inhibition mechanism. It enters cells to engage target, potently...
Chordomas account for approximately 1–4% of all malignant bone tumors and 20% primary the spinal column. It is a rare disease, with an incidence estimated to be 1 per 1,000,000 people. The underlying causative mechanism chordoma unknown, which makes it challenging treat. have been linked T-box transcription factor T (TBXT) gene located on chromosome 6. TBXT encodes protein TBXT, or brachyury homolog. Currently, there no approved targeted therapy chordoma. Here, we performed small molecule...
Human leukocyte antigens (HLA) are unique proteins expressed on the surface of human cells, playing a pivotal role in immune system, particularly contexts infection, cancer, and transplantation. The widespread adoption HLA typing methods has become an essential component assessing donor-recipient compatibility, crucial limiting factor solid organ In general, greater disparity between donor's recipient's types, higher likelihood provoking alloimmune response, which frequently results graft...