A5082976997- Health Literacy and Information Accessibility
- Mobile Health and mHealth Applications
- Social Media in Health Education
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Healthcare cost, quality, practices
- Renal Diseases and Glomerulopathies
- Global Maternal and Child Health
- Organ Donation and Transplantation
- Parathyroid Disorders and Treatments
- Diversity and Career in Medicine
- Molecular Biology Techniques and Applications
- Gene expression and cancer classification
- Birth, Development, and Health
- Acute Kidney Injury Research
- Genetic Syndromes and Imprinting
- Hypertrophic osteoarthropathy and related conditions
- Renal and Vascular Pathologies
- Bioinformatics and Genomic Networks
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- Phosphodiesterase function and regulation
- Global Public Health Policies and Epidemiology
- Cancer Immunotherapy and Biomarkers
- Blood Pressure and Hypertension Studies
Brigham and Women's Hospital
2016-2025
Harvard University
2016-2025
Beth Israel Deaconess Medical Center
2025
Renal Research Institute
2022
Clinical Trial Investigators
2022
UC Irvine Health
2022
University Hospital Coventry
2012
Harvard University Press
2011
Massachusetts General Hospital
2002
Wesleyan University
2002
Klotho is known to function as a cofactor for the phosphatonin, fibroblast growth factor (FGF)-23 at kidney. FGF-23 levels rise in chronic kidney disease (CKD) despite progression of accelerated vascular calcification. There are currently conflicting data on whether may exhibit direct vasculoprotective effects CKD.In this study, we describe first time endogenous expression human arteries and aortic smooth muscle cells. We show that CKD state deficiency promoted by circulating stress factors,...
Kidney injury molecule 1 (KIM-1, also known as TIM-1) is markedly upregulated in the proximal tubule after and maladaptive when chronically expressed. Here, we determined that early process, however, KIM-1 expression antiinflammatory due to its mediation of phagocytic processes cells. Using various models acute kidney (AKI) mice expressing mutant forms KIM-1, demonstrated a mucin domain–dependent protective effect epithelial involves downregulation innate immunity. Deletion domain impaired...
Cyclin G1 regulates G 2 -M arrest in proximal tubular cells, promoting a TASCC-induced secretory phenotype, fibrosis, and kidney disease progression.
Signal transduction and activator of transcription 3 (STAT3) is a key factor implicated in the pathogenesis kidney fibrosis. Although Stat3 deletion tubular epithelial cells known to protect mice from fibrosis, vFoxd1 remains unclear. Using Foxd1-mediated knockout mice, CRISPR, inhibitors STAT3, we investigate its function. STAT3 phosphorylated acute injury, whereas it expanded interstitial fibrosis humans. protects folic-acid- aristolochic-acid-induced Mechanistically, upregulates...
Historically, it takes an average of 17 years to move new treatments from clinical evidence daily practice. Given the highly effective now available prevent or delay kidney disease onset and progression, this is far too long. The time narrow gap between what we know do. Clear guidelines exist for prevention management common risk factors disease, such as hypertension diabetes, but only a fraction people with these conditions worldwide are diagnosed, even fewer treated target. Similarly, vast...
Shah, Rishi M.; Sridhar, Adhvaith; Kavya Stickels, Katie; Crowther, Megan; Kugler, Celine; Zhong, Anthony; Hsiao, Li-Li Author Information
Early identification of kidney disease can protect health, prevent progression and related complications, reduce cardiovascular risk, decrease mortality. We must ask “Are your kidneys ok?” using serum creatinine to estimate function urine albumin assess for endothelial damage. Evaluation causes risk factors chronic (CKD) includes testing diabetes measurement blood pressure body mass index. This World Kidney Day we assert that case-finding in high-risk populations, or even population level...
Early identification of kidney disease can protect health, prevent progression and related complications, reduce cardiovascular risk, decrease mortality. We must ask “Are your kidneys ok?” using serum creatinine to estimate function urine albumin assess for endothelial damage. Evaluation causes risk factors chronic (CKD) includes testing diabetes measurement blood pressure body mass index. This World Kidney Day we assert that case-finding in high-risk populations, or even population level...
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Technologies that rapidly isolate viable single cells from heterogeneous solutions have significantly contributed to the field of medical genomics. Challenges remain both enable efficient extraction, isolation and patterning as well keep them alive during process due a limited degree control over cell manipulation. Here, we present microdroplet based method pattern suspensions (10% target mixture), preserve viability extracted (97.0±0.8%), obtain genomic information isolated compared...
Endothelial cells (ECs) express fibroblast growth factor (FGF) receptors and are metabolically active after treatment with FGF-23. It is not known if this effect α-Klotho independent or mediated by humoral endogenous endothelial α-Klotho. In the present study, we aimed to characterize EC expression within human vascular tree investigate potential role of in determining FGF-23 regulation. Human tissue ECs from various organs were used for immunohistochemistry Western blot. Primary cultures...
Cardiovascular fibrosis is a major contributor to cardiovascular disease, the primary cause of death in patients with chronic kidney disease (CKD). We previously reported expression endogenous Klotho human arteries, and that CKD state deficiency, resulting vascular calcification, but myocardial poorly understood. This study aimed further clarify Klotho's functional roles cardiac underlying CKD.Human atrial appendage specimens were collected during surgery from individuals or without CKD....
Resumo A elevada carga da doença renal, disparidades globais no cuidado renal e desfechos ruins insuficiência impõem uma sobrecarga crescente aos indivíduos afetados suas famílias, cuidadores a própria comunidade geral. Educação em saúde é o grau que organizações têm, ou igualmente permitem tenham, capacidade de encontrar, compreender utilizar informações serviços para tomar decisões ações conscientes relacionadas à si outros. Mais do enxergar educação como um problema dos pacientes,...
Pancreatic cancer (pancreatic ductal adenocarcinoma, PDAC) remains a deadly worldwide with need for new therapeutic approaches. A dysregulation in the equilibrium between pro- and anti-inflammatory responses predominant immunosuppressive inflammatory reaction advanced stage tumors seem to contribute tumor growth metastasis. The current therapies do not include strategies against pro-tumorigenic inflammation patients. We have shown that upregulated cell surface expression of Toll-like...