A5012588346- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Virus-based gene therapy research
- Autism Spectrum Disorder Research
- Neurological disorders and treatments
- Obsessive-Compulsive Spectrum Disorders
Harvard University
2020-2023
Koch Institute for Integrative Cancer Research At MIT
2022-2023
Brigham and Women's Hospital
2020-2023
Johns Hopkins University
2022-2023
Allen Institute
2022-2023
Massachusetts Institute of Technology
2020
Boston University
2020
Chimeric antigen receptor (CAR) T cell therapy effectively treats human cancer, but the loss of recognized by CAR poses a major obstacle. We found that in vivo vaccine boosting cells triggers engagement endogenous immune system to circumvent antigen-negative tumor escape. Vaccine-boosted promoted dendritic (DC) recruitment tumors, increased uptake DCs, and elicited priming anti-tumor cells. This process was accompanied shifts metabolism toward oxidative phosphorylation (OXPHOS) critically...
Adoptive cell transfer of ex vivo expanded regulatory T cells (Tregs) has shown immense potential in animal models auto- and alloimmunity. However, the effective translation such Treg therapies to clinic been slow. Because homeostasis is known require continuous receptor (TCR) ligation exogenous interleukin-2 (IL-2), some investigators have explored use low-dose IL-2 injections increase endogenous responses. Systemic immunotherapy, however, can also lead activation cytotoxic lymphocytes...
Autism spectrum disorder (ASD) is behaviorally defined and diagnosed by delayed and/or impeded language, stereotyped repetitive behaviors, difficulties with social interactions. Additionally, there are disruptions in motor processing, which includes the intent to execute movements, interrupted/inhibited action chain sequences, impaired execution of speech, behaviors. Cortical loops through basal ganglia (BG) structures known play critical roles typical functioning these actions....
Significance There is increasing evidence that CD8 + regulatory T cells (CD8 Treg) can modulate the immune response in context of autoimmune disease, infection, and cancer. Here we asked whether this mechanism might control host to transplanted heart allografts. We report Treg recognize Qa-1, murine homolog HLA-E, strongly inhibits production antibodies specific for donor organ. Since antidonor currently a major barrier successful transplantation, identification Qa-1/HLA-E-dependent pathway...
Regulatory T cells (T regs ) have shown great promise as a means of cellular therapy in multitude allo- and auto-immune diseases—due part to their immunosuppressive potency. Nevertheless, the clinical efficacy human patients has been limited by poor vivo homeostasis. To avert apoptosis, require stable antigenic (CD3ζ/T-cell-receptor-mediated), co-stimulatory (CD28-driven), cytokine (IL-2-dependent) signaling. Notably, this sequence signals supports an activated reg phenotype that includes...
In the transplant community, research efforts exploring endogenous alternatives to inducing tolerogenic allo-specific immune responses are much needed. this regard, CD4 + FoxP3 regulatory T cells (T regs ) appealing candidates due their intrinsic natural immunosuppressive qualities. To date, various homeostatic factors that dictate reg survival and fitness have been elucidated, particularly non-redundant roles of antigenic CD3 ζ /T-cell-receptor, co-stimulatory CD28, cytokine interleukin...
Abstract Chimeric Antigen Receptor (CAR) T-cell therapy can be effective in treating human cancer but loss of the antigen recognized by CAR poses a major obstacle. Here, we report an approach for vaccine boosting T-cells, which triggers engagement endogenous immune system to circumvent antigen-negative tumor escape. Vaccine-boosted T-cells promoted dendritic cell (DC) recruitment tumors, increased uptake DCs, and elicited priming anti-tumor (antigen spreading). This process was accompanied...